PostCovidZRS: Post COVID19 Functional and Cognitive Assessments
Study Details
Study Description
Brief Summary
The main objective of the proposed study is to evaluate the impact of coronavirus (2019-nCoV), hereafter COVID -19, on patients' loss of functional capacity after completion of hospital treatment. Specifically, the research will focus on examining changes in musculoskeletal, cardiovascular, and respiratory function, as well as motor control. In addition, we aim to evaluate rehabilitation treatments after recovery from COVID -19 and consider additional preventive measures based on previous experience.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
The combination of such a severe respiratory disease as COVID -19 with motor inactivity could have very serious consequences for a person's general health even after COVID -19 symptoms have subsided. To date, the effects of COVID -19 on individual muscle status have not been extensively studied. Therefore, the main objective of this study will be to evaluate the muscle status of patients after COVID -19. In addition, we will be interested in longitudinal monitoring of individuals' rehabilitation, where they will receive instructions based on measured outcomes at hospital discharge. We will also be interested in considering additional preventive measures for future patients based on previous experience of infected and hospitalized COVID -19 patients.
Study Design
Outcome Measures
Primary Outcome Measures
- Timed up and go test (TUG) [Change in time on TUG between both assessment points (pre- to 2 months post-measurement)]
Functional performance of the patients from sitting to standing, walking and turning
- Pulse wave velocity (PWV) [Change in PWV between both assessment points (pre- to 2 months post-measurement)]
Measuring endothelium function in supine
- Spirometry [Change in FVC (%) between both assessment points (pre- to 2 months post-measurement)]
Measurement of lung function, specifically the forced vital capacity (FVC)
Secondary Outcome Measures
- Walking velocity [Change in gait velocity between both assessment points (pre- to 2 months post-measurement)]
measurement of gait velocity on the 4m path.
- Trail making test B [Change in time to solve the TMT B test between both assessment points (pre- to 2 months post-measurement)]
Measurement of executive control using the TMT B test
Eligibility Criteria
Criteria
Inclusion Criteria:
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Completed hospital treatment after a positive COVID-19 test
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Signed written consent
Exclusion Criteria:
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Still testing positive for COVID -19 at discharge.
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Severe musculoskeletal injuries (e.g., disability).
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Inability to follow instructions when performing the test.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | SB Izola | Izola | Slovenia |
Sponsors and Collaborators
- Science and Research Centre Koper
- Hospital of Izola
- University of Trieste
- University of Padova
- University of Graz
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Ammar A, Brach M, Trabelsi K, Chtourou H, Boukhris O, Masmoudi L, Bouaziz B, Bentlage E, How D, Ahmed M, Müller P, Müller N, Aloui A, Hammouda O, Paineiras-Domingos LL, Braakman-Jansen A, Wrede C, Bastoni S, Pernambuco CS, Mataruna L, Taheri M, Irandoust K, Khacharem A, Bragazzi NL, Chamari K, Glenn JM, Bott NT, Gargouri F, Chaari L, Batatia H, Ali GM, Abdelkarim O, Jarraya M, Abed KE, Souissi N, Van Gemert-Pijnen L, Riemann BL, Riemann L, Moalla W, Gómez-Raja J, Epstein M, Sanderman R, Schulz SV, Jerg A, Al-Horani R, Mansi T, Jmail M, Barbosa F, Ferreira-Santos F, Šimunič B, Pišot R, Gaggioli A, Bailey SJ, Steinacker JM, Driss T, Hoekelmann A. Effects of COVID-19 Home Confinement on Eating Behaviour and Physical Activity: Results of the ECLB-COVID19 International Online Survey. Nutrients. 2020 May 28;12(6). pii: E1583. doi: 10.3390/nu12061583.
- Ammar A, Chtourou H, Boukhris O, Trabelsi K, Masmoudi L, Brach M, Bouaziz B, Bentlage E, How D, Ahmed M, Mueller P, Mueller N, Hsouna H, Aloui A, Hammouda O, Paineiras-Domingos LL, Braakman-Jansen A, Wrede C, Bastoni S, Pernambuco CS, Mataruna L, Taheri M, Irandoust K, Khacharem A, Bragazzi NL, Strahler J, Washif JA, Andreeva A, Khoshnami SC, Samara E, Zisi V, Sankar P, Ahmed WN, Romdhani M, Delhey J, Bailey SJ, Bott NT, Gargouri F, Chaari L, Batatia H, Ali GM, Abdelkarim O, Jarraya M, Abed KE, Souissi N, Gemert-Pijnen LV, Riemann BL, Riemann L, Moalla W, Gómez-Raja J, Epstein M, Sanderman R, Schulz S, Jerg A, Al-Horani R, Mansi T, Jmail M, Barbosa F, Ferreira-Santos F, Šimunič B, Pišot R, Pišot S, Gaggioli A, Zmijewski P, Apfelbacher C, Steinacker J, Saad HB, Glenn JM, Chamari K, Driss T, Hoekelmann A, On Behalf Of The Eclb-Covid Consortium. COVID-19 Home Confinement Negatively Impacts Social Participation and Life Satisfaction: A Worldwide Multicenter Study. Int J Environ Res Public Health. 2020 Aug 27;17(17). pii: E6237. doi: 10.3390/ijerph17176237.
- Pišot R, Marusic U, Biolo G, Mazzucco S, Lazzer S, Grassi B, Reggiani C, Toniolo L, di Prampero PE, Passaro A, Narici M, Mohammed S, Rittweger J, Gasparini M, Gabrijelčič Blenkuš M, Šimunič B. Greater loss in muscle mass and function but smaller metabolic alterations in older compared with younger men following 2 wk of bed rest and recovery. J Appl Physiol (1985). 2016 Apr 15;120(8):922-9. doi: 10.1152/japplphysiol.00858.2015. Epub 2016 Jan 28.
- PC-ZRS-SBI