Pain After Laparoscopy Results From the Incision, Manipulation of the Abdominal Organs, and Retained CO2(Back Pain)
Study Details
Study Description
Brief Summary
Postoperative pain after laparoscopy may be localized pain resulting from incision due to many (two or three) punctures (somatic pain) or due to manipulation of the intra-abdominal organs as ovaries, uterus, omentum, and intestine (visceral pain) or shoulder and back pain caused by retained CO2 in the peritoneal cavity with its irritation effect on the diaphragm.Patients will be divided into two groups:
Intraperitoneal (IP) group (20 patients):They will receive 100 ml normal saline infused over 10 min immediately before the induction of anesthesia and then continuous infusion of 500 ml normal saline intraoperatively then intraperitoneal wash of 100 ml normal saline containing 30 mg/kg MgSO4 at the end of laparoscopy.
Intravenous (IV) group (20 patients):They will receive 100 ml normal saline containing MgSO4 30 mg/kg infused over 10 min immediately before the induction of anesthesia and then continuous infusion of 500 ml normal saline containing MgSO4 (8mg/kg) intraoperatively then intraperitoneal wash using 100 ml normal saline at the end of laparoscopy
Condition or Disease | Intervention/Treatment | Phase |
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Phase 2 |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Active Comparator: Intraperitoneal magnesium sulfate (IP) group They will receive 100 ml normal saline infused over 10 min immediately before the induction of anesthesia and then continuous infusion of 500 ml normal saline intraoperatively then an intraperitoneal wash of 100 ml normal saline containing 30 mg/kg MgSO4 at the end of laparoscopy. |
Drug: intraperitoneal Magnesium sulfate
Intraperitoneal (IP) group will receive 100 ml normal saline infused over 10 min immediately before the induction of anesthesia and then continuous infusion of 500 ml normal saline intraoperatively then intraperitoneal wash of 100 ml normal saline containing 30 mg/kg MgSO4 at the end of laparoscopy.
|
Active Comparator: Intravenous magnesium sulfate (IV) group They will receive 100 ml normal saline containing MgSO4 30 mg/kg infused over 10 min immediately before the induction of anesthesia and then continuous infusion of 500 ml normal saline containing MgSO4 (8mg/kg) intraoperatively then intraperitoneal wash using 100 ml normal saline at the end of laparoscopy. |
Drug: intravenous magnesium sulfate
Intravenous (IV) group will receive 100 ml normal saline containing MgSO4 30 mg/kg infused over 10 min immediately before the induction of anesthesia and then continuous infusion of 500 ml normal saline containing MgSO4 (8mg/kg) intraoperatively then intraperitoneal wash using 100 ml normal saline at the end of laparoscopy.
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Outcome Measures
Primary Outcome Measures
- Time for first dose of rescue analgesia [8 hours]
1st time to feel pain
- total analgesic doses [8 hours]
total (ketorolac) analgesic consumption
Secondary Outcome Measures
- post operative pain [8 hours]
The visual analog scale(0-10 with 0 is no pain and 10 is maximum intolerable pain)
- sedation [8 hours]
4 points sedation scale: 0= alert and conscious 1 =quietly awake 2= asleep but easily arousable 3= deep sleep
- adverse events [8 hours]
side effects
- serum mgso4 level [2 hours]
serum level of mgso4 at end of operation and after 2 hours
Eligibility Criteria
Criteria
Inclusion Criteria:
20-44 years old females, (ASA) class I-II
Exclusion Criteria:
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Patient refusal
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Allergy to MgSO4
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Atrio-ventricular conduction abnormalities
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Drug abuse
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Renal or hepatic or cardiovascular dysfunction
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Prior long-term treatment with calcium channel blockers or magnesium
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Fouad Soliman | Sohag | Egypt | 52514 |
Sponsors and Collaborators
- Sohag University
Investigators
- Principal Investigator: Fouad Soliman, Sohag University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2007