I-TSPT-R: Memory Inhibition and Delayed Onset Post-traumatic Stress Disorder in Older Subjects

• Sponsor: Centre Hospitalier de Niort (Other)
• Overall Status: Completed
• CT.gov ID: NCT03897855
• Collaborator: (none)
• Enrollment: 20
• Location: 1
• Arms: 2
• Actual Duration (Months): 23.8
• Patients Per Site Per Month: 0.8

Study Details

Study Description

Brief Summary

In the elderly, we can see a post-traumatic syndrome associated with an event that occurred before old age that had not previously manifested or not fully manifested.

This little-known pathology and notable psychiatric co-morbidities (depression, anxiety) can take in elderly subjects different masks that interfere with diagnosis and treatment.

The data in the literature suggest that this Post-Traumatic Stress Disorder with Delayed Expression (TSPT-R) may be related to a deficiency of the executive functions of inhibition, and more particularly a deficit of mental memory inhibition and therefore the removal of unwanted memories.

Condition or Disease	Intervention/Treatment	Phase
Post-Traumatic Stress Disorder in Old Age	Other: Post Traumatic Stress Disorder	N/A

Study Design

• Study Type: Interventional
• Actual Enrollment: 20 participants
• Allocation: Non-Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Diagnostic
• Official Title: Memory Inhibition and Delayed Onset Post-traumatic Stress Disorder in Older Subjects
• Actual Study Start Date: Apr 1, 2019
• Actual Primary Completion Date: Apr 15, 2019
• Actual Study Completion Date: Mar 26, 2021

Arms and Interventions

Arm	Intervention/Treatment
Other: Patient (TSPT-R) Post Traumatic Stress Disorder	Other: Post Traumatic Stress Disorder; The test "Think / No-Think"
Experimental: control No Post Traumatic Stress Disorder	Other: Post Traumatic Stress Disorder; The test "Think / No-Think"

Outcome Measures

Primary Outcome Measures

1. Inhibition score measured by the Think / No-Think Test [1 month]

   the average of the inhibition score measured by the "Think / No-Think" test as defined by Anderson and Green (2001) and then reviewed by Anderson et al. in 2011

Eligibility Criteria

Criteria

• Ages Eligible for Study: 65 Years to 85 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

Regarding the constitution of the group patient (TSPT-R):

• Subjects 65 years of age or older

• Clinical diagnosis of delayed-onset PTSD according to DSM-5 criteria after 65 years

• The traumatic event must have taken place at the latest before 65 years

• Affiliated person or beneficiary of a social security scheme.

• Written consent before any examination required by research)

Regarding the constitution of the control group:

• Subjects 65 years of age or older

• No diagnosis of PTSD (delayed or not) or history of PTSD (delayed or not)

• Affiliated person or beneficiary of a social security scheme.

• Written consent before any examination required by the research).

Exclusion Criteria:

• For both groups:

• Acute or chronic cognitive impairment known

• GRECO MMSE pathological score less than or equal to the pathological threshold weighted according to level of education and age, namely:

• 22 if no diploma

• 23 if certificate of study

• 25 if patent

• 26 if bin or more

• Remove one point at each threshold if age> 80 years

• Sensory or motor disorder preventing the passing of different tests

• Psychotic disorder

• Mood disorder in decompensation (for depression, HAD-D score equal to or greater than

• Disorder of the use of a moderate or severe substance (except tobacco).

• Patients under guardianship or curatorship.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Centre Hospitalier de Niort	Niort		France	79021

Sponsors and Collaborators

• Centre Hospitalier de Niort

Investigators

• Study Director: Dominique LEGER, Doctor, Centre Hospitalier de Niort

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Centre Hospitalier de Niort
• ClinicalTrials.gov Identifier: NCT03897855
• Other Study ID Numbers: CH-NIORT-2018-02
• First Posted: Apr 1, 2019
• Last Update Posted: Jul 30, 2021
• Last Verified: Jul 1, 2021

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Stress Disorders, Traumatic; Stress Disorders, Post-Traumatic

Study Results

No Results Posted as of Jul 30, 2021