QUIT-COC: Predicting Relapse After Cocaine Inpatient Cessation
Study Details
Study Description
Brief Summary
Can brain MRI at entry of cocaine inpatient cessation attempt predict relapse during a three month follow-up ? Hypothesis : White matter losses in the prefrontal cortex are associated with relapse to cocaine use.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Detailed Description
A multivariate model using MRI parameters, craving score, impulsivity score, and neuropsychological testing results will be tested to predict relapse or continuous abstinence three month after cocaine inpatient cessation attempt.
Study Design
Outcome Measures
Primary Outcome Measures
- mean difference of fractional anisotropy of the prefrontal cortex (PFC) in patients abstinent from cocaine 3 months after inpatient detoxification compared to relapsers [at 3 months]
Secondary Outcome Measures
- Comparisons between patients who remain abstinent from cocaine 3 months after inpatient detoxification and those who relapse [at baseline]
Differences in grey and white matter volumes : voxel-based morphometry (VBM) and in resting-state whole-brain activity default mode network (DMN)
- Comparisons between patients who remain abstinent from cocaine 3 months after inpatient detoxification and those who relapse [at baseline]
Differences in scores of craving (visual scale and Obsessive compusilve craving scale (OCCS) questionnaire) and impulsivity (UPPS)
- Comparisons between patients who remain abstinent from cocaine 3 months after inpatient detoxification and those who relapse [at baseline]
Differences in performance at the stroop test and in mental flexibility during an implicit set shifting task
- Among abstinent patients who remain abstinent at three months only :Differences between baseline and 3 months measures of Diffusion Tensor Imagery (DTI), VBM and DMN [at 3 months]
- Among abstinent patients who remain abstinent at three months only: Differences in scores of craving (visual scale and OCCS questionnaire) and impulsivity (UPPS) [at 3 months]
- Among abstinent patients who remain abstinent at three months only: Differences in performance at the stroop test and in mental flexibility during an implicit set shifting task compared to baseline results [at 3 months]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
cocaine dependent patient requiring inpatient cessation
-
18 years old and older
-
giving his/her consent to come back for visits up to three months
-
having a social insurance
Exclusion Criteria:
-
minor
-
under guardianship
-
restraint hospitalization
-
contraindication to brain MRI
-
pregnant women
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Service de Psychiatrie, Hôpital Fernand Widal | Paris | France | 75010 |
Sponsors and Collaborators
- Assistance Publique - Hôpitaux de Paris
Investigators
- Principal Investigator: Florence VORSPAN, MD, PhD, Assistance Publique - Hôpitaux de Paris
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- P120125
- 2014-A01169-38