The Predictive and Diagnostic Value of Cystatin C and High Sensitive Troponin
Study Details
Study Description
Brief Summary
Our study is planning to evaluate patients with chronic kidney disease who come to the emergency department with chest pain. Estimated GFR (cisGFR) with cystatin and estimated GFR (creaGFR) with creatinine will be calculated. Symptoms, ECG and troponin values of patients will be evaluated for diagnosis of acute coronary syndrome
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Our study is planning to evaluate patients with chronic kidney disease who come to the emergency department with chest pain. Estimated GFR (cisGFR) with cystatin and estimated GFR (creaGFR) with creatinine will be calculated. Symptoms, ECG and troponin values of patients will be evaluated for diagnosis of acute coronary syndrome and the final diagnosis of AMI will be adjudicated by 2 independent cardiologists.Serial troponin measurements and eGFR values will be proportioned. These values the will be evaluated and compared for patients with acute coronary syndrome(culprit lesion on conventional coronary angiography) and non-ACS ones . With these data we aim to facilitate the diagnosis of acute coronary syndrome,increase the specificity and sensitivity of cardiac troponins for the diagnosis of acute coronary syndrome of patients with chronic kidney disease, increase the utility of high sensitive troponins for patients with chronic kidney disease. Again, with these data, it is aimed to reduce the number of false negative and false positive diagnosis of acute coronary syndrome .
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| patients with acute coronary syndrome patients with chronic kidney disease having chest pain with ecg, symptom or cardiac troponin levels compatible with ACS |
Procedure: percutaneous coronary intervention
conventional coronary angiography
|
| patients without acute coronary syndrome patients with chronic kidney disease having chest pain with ecg, symptom or cardiac troponin levels NONcompatible with ACS |
Outcome Measures
Primary Outcome Measures
- anticipated ACS [time passed until PCI (percutaneous coronary intervention) (pre-intervention) or admission to hospital]
The role of cystatin C in diagnosis acute coronary syndrome when used with troponin in patients with chronic renal failure.
- exclusion of acs [time passed during emergency department visit until discharge avarage of 3-6 hours]
exclusion of ACS according to current guidelines
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Age over 18,
-
chronic kidney diease having chest pain or equivalent of chest pain (dyspnea, diaphoresis, syncope, nausea, vomiting) -
Exclusion Criteria:
-
STEMI,
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age less than 18,
-
missing data,
-
patients referred to or accepted from another medical facility
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Diskapi Research and Training Hospital | Ankara | Turkey | 06110 |
Sponsors and Collaborators
- Ankara Diskapi Training and Research Hospital
Investigators
- Study Director: bedriye müge sönmez, assoc. prof., research
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- AnkaraDiskapiTRH