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POCoMS: Pregnancy Outcomes in Congenital Myasthenie Syndrome

Sponsor
Institut de Myologie, France (Other)
Overall Status
Completed
CT.gov ID
NCT01474980
Collaborator
Assistance Publique - Hôpitaux de Paris (Other)
25
Enrollment
21
Duration (Months)

Study Details

Study Description

Brief Summary

This is a retrospective study that follows the clinical evolution, the pregnancy and the post-partum perioad of female patients with Congenital Myasthenic Syndrome.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    The aim of this study is to better understand the action of hormonal factors that are presumably incriminated for the fluctuation of the disease. The investigators would also like to better adress the issues of women with Congenital Myasthenic Syndrome, who desire a pregnancy : the possibility of decompensation, the problems that can arise during the course of the childbearing, the risk of foetal malformations.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    25 participants
    Observational Model:
    Cohort
    Time Perspective:
    Retrospective
    Official Title:
    Retrospective Study :Describe the Changes of the Disease in Many Cases Likely to Aggravate.
    Study Start Date :
    Jan 1, 2010
    Actual Primary Completion Date :
    Jan 1, 2011
    Actual Study Completion Date :
    Oct 1, 2011

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years and Older
      Sexes Eligible for Study:
      Female
      Accepts Healthy Volunteers:
      No
      Inclusion criteria:

      • Adult women

      • Congenital myastenic syndrome genetically confirmed or with clinical compatible and electrophysiological evidence

      • Written consent

      Exclusion Criteria:
      • Neurological or general pathology occurs significantly with the initiation and conduct of a pregnancy.

      Contacts and Locations

      Locations

      No locations specified.

      Sponsors and Collaborators

      • Institut de Myologie, France
      • Assistance Publique - Hôpitaux de Paris

      Investigators

      • Principal Investigator: Laurent SERVAIS, MD, PhD, institut myologie

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      Laurent Servais, M.D., Laurent SERVAIS MD, PhD, Institut de Myologie, France
      ClinicalTrials.gov Identifier:
      NCT01474980
      Other Study ID Numbers:
      • 2010-A00495-34
      First Posted:
      Nov 18, 2011
      Last Update Posted:
      Nov 18, 2011
      Last Verified:
      Nov 1, 2011
      Keywords provided by Laurent Servais, M.D., Laurent SERVAIS MD, PhD, Institut de Myologie, France
      Congenital Myasthenic Syndrome
      Pregnancy
      Outcome
      Additional relevant MeSH terms:
      Lambert-Eaton Myasthenic Syndrome
      Myasthenic Syndromes, Congenital
      Syndrome

      Study Results

      No Results Posted as of Nov 18, 2011