Study of the Association Between Presbycusis With the Incidence of Frailty
Study Details
Study Description
Brief Summary
The objective of the project is to establish the association between presbycusis and the incidence of frailty in humans in order to establish hearing loss with age as another index for the diagnosis of frailty; As well as studying the effect of exposure to polyphenols in the diet on presbycusis and frailty. Human study: volunteers between 60 and 99 years old, men and women during a period of 6 months, questions and answers, audiometries, study of fragility, analysis of antioxidants in blood, and samples of urine will be measured Total polyphenols and oxidant capacity.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Outcome Measures
Primary Outcome Measures
- Auditory function [6 months]
study by pure tone audiometry, calculating an average of the thresholds of hearing at 0.5, 1, 2 and 4 kilohertz classifying according to their hearing thresholds to the participants in: normal hearing ≤ 25decibel, slight hearing loss = 26-40 decibel; Y moderate-greater hearing loss> 40 decibel (according to the World Health Organization).
- Frailty [6 months]
Fragility will be determined at the beginning and at the end of the study period using the 5 Fried indexes: weakness, low speed, low physical activity, exhaustion and weight loss. Participants with 3 or more criteria are classified as fragile, with 1-2 criteria as pre-fragile, and those without any criteria are not considered fragile. Thus, individuals will be classified in the analyzes as non-fragile, pre-fragile and fragile.
Secondary Outcome Measures
- Determination of total polyphenols in urine [measured twice in each volunteer, at the beginning and end of the study period (6 months)]
24-hour urine samples using the method Folin -Ciocalteu.
- Blood analysis, [It will be performed at the beginning and at end of the study period (6 months)]
routine biochemistry and determination of: carotenoids, vitamins E and D
- Microbiota [It will be performed at the beginning and at end of the study period (6 months)]
Stool microbiota analysis
Eligibility Criteria
Criteria
Inclusion Criteria:
- Age
Exclusion Criteria:
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Disease of the hearing system
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Serious illness (e.g. tumor)
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Dementia
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Total dependence
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Hospital Universitario de Getafe | Getafe | Madrid | Spain | 28905 |
Sponsors and Collaborators
- Universidad Europea de Madrid
Investigators
- Principal Investigator: Carolina S Rodríguez, Universidad Europea de Madrid
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- PI19/01524