Radiation Therapy With or Without Androgen-Deprivation Therapy in Treating Patients With Prostate Cancer

Sponsor
Radiation Therapy Oncology Group (Other)
Overall Status
Active, not recruiting
CT.gov ID
NCT00936390
Collaborator
National Cancer Institute (NCI) (NIH), NRG Oncology (Other)
1,538
518
2
211.9
3
0

Study Details

Study Description

Brief Summary

RATIONALE: Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells and shrink tumors. Androgens can cause the growth of prostate cancer cells. Androgen-deprivation therapy may lessen the amount of androgens made by the body. It is not yet known whether radiation therapy is more effective with or without androgen-deprivation therapy in treating patients with prostate cancer.

PURPOSE: This randomized phase III trial is studying radiation therapy to see how well it works compared with radiation therapy given together with androgen-deprivation therapy in treating patients with prostate cancer.

Condition or Disease Intervention/Treatment Phase
Phase 3

Detailed Description

OBJECTIVES:

Primary

  • Demonstrate an overall survival (OS) advantage in patients with intermediate-risk prostate cancer treated with dose-escalated radiotherapy (RT) with versus without short-term androgen-deprivation therapy (ADT).

Secondary

  • Determine whether the addition of ADT to dose-escalated RT versus RT alone improves clinical failures, biochemical failure by the "nadir +2", freedom from failure, rate of salvage ADT, and prostate cancer-specific mortality in these patients.

  • Estimate the magnitude of benefit of ADT with respect to OS in patients treated with different RT modalities (i.e., external-beam radiation therapy alone vs low-dose rate brachytherapy boost vs high-dose rate brachytherapy boost).

  • Compare acute and late treatment adverse events of these regimens and correlate these events with the presence or absence of pre-existing comorbidity as documented by the Adult Comorbidity Evaluation 27 assessment.

OUTLINE: This is a multicenter, dose-escalation study of radiotherapy. Patients are stratified according to number of risk factors (1 vs 2-3), comorbidity (ACE-27 grade ≥ 2 vs < 2), and radiotherapy (RT) modality (dose-escalated external-beam RT [EBRT] vs EBRT and low-dose rate brachytherapy boost vs EBRT and high-dose rate brachytherapy boost). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients undergo EBRT* once daily on days 1-5 for about 9 weeks (44 treatments). Some patients instead receive EBRT with high-dose rate or low-dose rate brachytherapy implant on days 1-5 for about 5 weeks (25 treatments). NOTE: *Type of RT is at discretion of treating physician and may include either 3D-conformal RT or intensity-modulated RT.

  • Arm II: Patients receive androgen-deprivation therapy comprising luteinizing-hormone releasing-hormone (LHRH) agonist (leuprolide, goserelin, buserelin, or triptorelin) subcutaneously or as an injection every 1 to 3 months AND an oral antiandrogen therapy (flutamide 3 times daily or bicalutamide once daily) for 6 months. Beginning 8 weeks after the first LHRH injection, patients undergo radiotherapy as in arm I.

After completion of study therapy, patients are followed up periodically.

Study Design

Study Type:
Interventional
Actual Enrollment :
1538 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
A Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy With or Without Short-Term Androgen Deprivation Therapy for Patients With Intermediate-Risk Prostate Cancer
Study Start Date :
Sep 1, 2009
Anticipated Primary Completion Date :
May 1, 2022
Anticipated Study Completion Date :
May 1, 2027

Arms and Interventions

Arm Intervention/Treatment
Active Comparator: Arm I

Patients undergo external-beam radiation therapy (EBRT) once daily on days 1-5. Some patients instead receive EBRT with high-dose rate or low-dose rate brachytherapy implant.

Radiation: 3-dimensional conformal radiation therapy
Given as external-beam radiation therapy

Radiation: intensity-modulated radiation therapy
Given as external-beam radiation therapy

Experimental: Arm II

Patients receive androgen-deprivation therapy comprising luteinizing-hormone releasing-hormone (LHRH) agonist (leuprolide, goserelin, buserelin, or triptorelin) subcutaneously or as an injection every 1 to 3 months AND an oral antiandrogen therapy (flutamide 3 times daily or bicalutamide once daily) for 6 months. Beginning 8 weeks after the first LHRH injection, patients undergo radiotherapy as in arm I.

Drug: bicalutamide
Given orally

Drug: buserelin
Given subcutaneously or as an injection

Drug: flutamide
Given orally

Drug: goserelin acetate
Given subcutaneously or as an injection

Drug: leuprolide acetate
Given subcutaneously or as an injection

Drug: triptorelin
Given subcutaneously or as an injection

Radiation: 3-dimensional conformal radiation therapy
Given as external-beam radiation therapy

Radiation: intensity-modulated radiation therapy
Given as external-beam radiation therapy

Outcome Measures

Primary Outcome Measures

  1. Overall survival (OS) [From the date of randomization to the date of death due to any cause.]

Secondary Outcome Measures

  1. Biochemical failure according to the Phoenix (nadir + 2) definition [From the date of randomization to the date of first documented rise in PSA of 2 ng/ml above the post treatment nadir value.]

  2. Local recurrence [From the date of randomization to the date of first palpable progression or pathologic confirmation of local progression or to the date of first biochemical failure (nadir +2ng/ml) once the possibility of distant metastasis is ruled out.]

  3. Regional recurrence [From the date of randomization to the date of first documented progression in pelvic lymph nodes or the date of first documented biochemical failure (BCF) if the CT of the pelvis was prompted by a BCF.]

  4. Distant metastasis [From the date of randomization to the date of first documented metastatic disease by any measure or to the date of first documented biochemical failure if diagnostic imaging is prompted by BCF.]

  5. Prostate cancer-specific mortality [From the date of randomization to the date of death due to prostate cancer/complication of treatment.]

  6. Non-prostate cancer-specific mortality [From the date of randomization to the date of death without the evidence of prostate cancer/complication of treatment.]

  7. Rate of salvage androgen-deprivation therapy [From the end of treatment to the date of first administration of ADT.]

  8. Rates of OS for patients treated with the 3 different radiotherapy modalities in each arm [From the date of randomization to the date of death due to any cause.]

  9. Incidence of "acute" adverse events as assessed by NCI Common Toxicity Criteria for Adverse Effects (CTCAE) v. 4.0 [From the start of radiation therapy (RT) to first occurrence of worse severity of adverse event within 30 days after the completion of RT.]

  10. Time to "late" grade 3+ adverse events as assessed by NCI CTCAE v. 4.0 [From the date of completion of RT to the date of first grade 3 or above adverse event occurring 30 days after the completion of RT.]

  11. Freedom from Failure [From date of randomization to the date of first event of biochemical failure or local recurrence or regional reccurrence or distant metastasis.]

  12. Comparison of prostate cancer-specific health related quality of life (HRQOL) change as measured by EPIC [From date of randomization to the following times: last week of RT, 6 months, 1 year and 5 years post RT.]

  13. Comparison of fatigue status as measured by the Patient Reported Outcome Measurement Information System (PROMIS) fatigue domain [From date of randomization to the following times: last week of RT, 6 months, 1 year and 5 years post RT.]

  14. Assessment and comparison of Quality Adjusted Life Years (QALYs) [From date of randomization to the following times: last week of RT, 6 months, 1 year and 5 years post RT.]

  15. Correlation between the fatigue PROMIS score change and plasma cytokine change [From date of randomization to 3 weeks from start of RT.]

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years and Older
Sexes Eligible for Study:
Male
Accepts Healthy Volunteers:
No
DISEASE CHARACTERISTICS:
  • Histologically confirmed adenocarcinoma of the prostate diagnosed within the past 180 days and at intermediate-risk for recurrence by meeting 1 or more of the following criteria:

  • Gleason score = 7

  • Prostate Specific Antigen (PSA) > 10 and ≤ 20 ng/mL

  • Baseline serum PSA value performed within 60 days with an FDA-approved assay (e.g., Abbott, Hybritech)

  • Baseline PSA must not be obtained during any of the following time frames:10-day period after prostate biopsy, after initiation of androgen-deprivation therapy, or within the past 30 days after discontinuation of finasteride (90 days for dutasteride)

  • Clinical stage T2b or T2c disease

  • Patients previously diagnosed with low-risk (Gleason score < 6, clinical stage < T2a, and PSA < 10 ng/mL) prostate cancer undergoing active surveillance who are re-biopsied and found to have intermediate-risk disease according to the protocol criteria are eligible for enrollment within 6 months of the repeat biopsy procedure

  • Patients with Gleason Score ≥ 8, PSA > 20 ng/mL, OR clinical stage ≥ T3 are ineligible for this trial

  • If findings of extracapsular extension or seminal vesicle invasion are noted on prostate MRI, this study, if used, will not render patients ineligible for accrual to this protocol

  • Primary tumor staging for eligibility purposes is to be based on palpable or core biopsy evidence only with respect to extracapsular extension or seminal vesicle involvement

  • No patients with all 3 intermediate-risk factors who also have ≥ 50% of the number of their biopsy cores positive for cancer

  • The percentage of biopsy cores involved will only be considered with respect to eligibility for those patients with all 3 of the above risk factors (i.e., patients with one or two of the above risk factors are eligible irrespective of the percentage of biopsy cores involved)

  • Clinically negative lymph nodes as established by imaging (pelvic and/or abdominal CT scan or MRI), nodal sampling, or dissection within the past 60 days (required for patients with 2-3 risk factors)

  • Abdominal imaging not required for a single intermediate-risk factor (these studies may be obtained at the discretion of the treating physician)

  • Lymph nodes that are equivocal or questionable by imaging allowed without biopsy if nodes ≤ 1.5 cm

  • Any node > 1.5 cm on imaging requires a negative biopsy

  • No evidence of bone metastases on bone scan within the past 60 days

  • Bone scan not required for patients with a single intermediate-risk factor (scan may be obtained at the discretion of the treating physician)

  • Equivocal bone scan findings allowed if plain film x-rays negative for metastasis

PATIENT CHARACTERISTICS:
  • Zubrod performance status 0-1

  • Absolute neutrophil count (ANC) ≥ 1,800/mm^3*

  • Platelet count ≥ 100,000/mm^3*

  • Hemoglobin ≥ 8.0 g/dL (transfusion or other intervention to achieve level allowed)*

  • NOTE: *For patients undergoing brachytherapy only.

  • Fertile patients must use effective contraception during and for the 3 months after cessation of protocol treatment

  • No invasive malignancy or hematological malignancy (e.g., leukemia, lymphoma, myeloma) within the past 5 years except adequately treated non-melanomatous skin cancer

  • Prior diagnoses of carcinoma in situ allowed

  • No severe or active co-morbidity with any of the following:

  • Unstable angina and/or congestive heart failure requiring hospitalization within the past 6 months

  • Transmural myocardial infarction within the past 6 months

  • Acute bacterial or fungal infection requiring intravenous antibiotics

  • Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy, within the past 30 days

  • Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects

  • Laboratory tests for liver function and coagulation parameters not required for entry into this protocol

  • AIDS based upon current Centers for Disease Control (CDC) definition

  • HIV testing not required for entry into this protocol

  • HIV-seropositive patients who do not meet criteria for diagnosis of AIDS allowed

PRIOR CONCURRENT THERAPY:
  • See Disease Characteristics

  • No prior radical surgery (prostatectomy), high-intensity focused ultrasound, or cryosurgery for prostate cancer

  • No prior hormonal therapy, such as LHRH agonists (e.g., goserelin, leuprolide), antiandrogens (e.g., flutamide, bicalutamide), estrogens (e.g., DES), or bilateral orchiectomy

  • No finasteride within past 30 days (90 days for dutasteride)

  • No prior or concurrent cytotoxic chemotherapy for prostate cancer

  • Prior chemotherapy for a different cancer allowed

  • No prior radiotherapy (RT), including brachytherapy, to the region of the study cancer that would result in overlap of RT fields

  • Patients undergoing brachytherapy must have transrectal ultrasound confirmation of prostate volume < 60 cc, American Urological Association (AUA) score ≤ 15 within the past 60 days of registration, and no history of prior transurethral resection of the prostate (TURP)

  • TURP allowed for patients who receive external-beam radiation therapy only

Contacts and Locations

Locations

Site City State Country Postal Code
1 University of Alabama at Birmingham Cancer Center Birmingham Alabama United States 35233
2 Fairbanks Memorial Hospital Fairbanks Alaska United States 99701
3 Arizona Center for Cancer Care-Peoria Peoria Arizona United States 85381
4 Saint Joseph's Hospital and Medical Center Phoenix Arizona United States 85013
5 21st Century Oncology-Scottsdale Scottsdale Arizona United States 85251
6 Mayo Clinic in Arizona Scottsdale Arizona United States 85259
7 Arizona Oncology Services Foundation Scottsdale Arizona United States 85260
8 Arizona Oncology Associates-West Orange Grove Tucson Arizona United States 85704
9 Mercy Cancer Center-Hot Springs Hot Springs Arkansas United States 71913
10 Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn California United States 95603
11 Alta Bates Summit Medical Center-Herrick Campus Berkeley California United States 94704
12 Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank California United States 91505
13 Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park California United States 95682
14 Mercy San Juan Medical Center Carmichael California United States 95608
15 Enloe Medical Center Chico California United States 95926
16 21st Century Oncology - El Segundo El Segundo California United States 90245
17 Fresno Cancer Center Fresno California United States 93720
18 Saint Agnes Medical Center Fresno California United States 93720
19 Marin General Hospital Greenbrae California United States 94904
20 Veterans Administration Long Beach Medical Center Long Beach California United States 90822
21 Los Angeles County-USC Medical Center Los Angeles California United States 90033
22 USC / Norris Comprehensive Cancer Center Los Angeles California United States 90033
23 Memorial Medical Center Modesto California United States 95355
24 Kaiser Permanente Oakland-Broadway Oakland California United States 94611
25 Kaiser Permanente-Oakland Oakland California United States 94611
26 Desert Regional Medical Center Palm Springs California United States 92262
27 Stanford Cancer Institute Palo Alto California United States 94304
28 Feather River Cancer Center Paradise California United States 95969
29 Pomona Valley Hospital Medical Center Pomona California United States 91767
30 Kaiser Permanente-Rancho Cordova Cancer Center Rancho Cordova California United States 95670
31 Kaiser Permanente-Redwood City Redwood City California United States 94063
32 Kaiser Permanente-Richmond Richmond California United States 94801
33 Rohnert Park Cancer Center Rohnert Park California United States 94928
34 Kaiser Permanente-Roseville Roseville California United States 95661
35 Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville California United States 95661
36 The Permanente Medical Group-Roseville Radiation Oncology Roseville California United States 95678
37 Sutter General Hospital Sacramento California United States 95816
38 University of California Davis Comprehensive Cancer Center Sacramento California United States 95817
39 Mercy General Hospital Radiation Oncology Center Sacramento California United States 95819
40 Kaiser Permanente-South Sacramento Sacramento California United States 95823
41 South Sacramento Cancer Center Sacramento California United States 95823
42 Kaiser Permanente - Sacramento Sacramento California United States 95825
43 University of California San Diego San Diego California United States 92103
44 Kaiser Permanente-San Francisco San Francisco California United States 94115
45 UCSF Medical Center-Mount Zion San Francisco California United States 94115
46 California Pacific Medical Center-Pacific Campus San Francisco California United States 94118
47 Kaiser Permanente-Santa Teresa-San Jose San Jose California United States 95119
48 Kaiser Permanente San Leandro San Leandro California United States 94577
49 Kaiser Permanente-San Rafael San Rafael California United States 94903
50 Kaiser Permanente Medical Center - Santa Clara Santa Clara California United States 95051
51 Kaiser Permanente-Santa Rosa Santa Rosa California United States 95403
52 Kaiser Permanente Cancer Treatment Center South San Francisco California United States 94080
53 Kaiser Permanente-South San Francisco South San Francisco California United States 94080
54 Kaiser Permanente-Stockton Stockton California United States 95210
55 David Grant United States Air Force Medical Center Travis Air Force Base California United States 94535-1800
56 Tahoe Forest Cancer Center Truckee California United States 96161
57 Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville California United States 95687
58 Sutter Solano Medical Center/Cancer Center Vallejo California United States 94589
59 Kaiser Permanente-Walnut Creek Walnut Creek California United States 94596
60 Rocky Mountain Cancer Centers-Aurora Aurora Colorado United States 80012
61 University of Colorado Cancer Center - Anschutz Cancer Pavilion Aurora Colorado United States 80045
62 The Urology Center of Colorado Denver Colorado United States 80211
63 The Shaw Regional Cancer Center Edwards Colorado United States 81632
64 Poudre Valley Hospital Fort Collins Colorado United States 80524
65 Saint Mary's Hospital and Regional Medical Center Grand Junction Colorado United States 81502
66 Rocky Mountain Cancer Centers-Littleton Littleton Colorado United States 80120
67 Hartford Hospital Hartford Connecticut United States 06102
68 Saint Francis Hospital and Medical Center Hartford Connecticut United States 06105
69 Midstate Medical Center Meriden Connecticut United States 06451
70 The Hospital of Central Connecticut New Britain Connecticut United States 06050
71 Yale-New Haven Hospital Saint Raphael Campus New Haven Connecticut United States 06511
72 Helen F Graham Cancer Center Newark Delaware United States 19713
73 Christiana Care Health System-Christiana Hospital Newark Delaware United States 19718
74 University of Miami Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida United States 33442
75 Broward Health Medical Center Fort Lauderdale Florida United States 33316
76 Mayo Clinic in Florida Jacksonville Florida United States 32224-9980
77 Florida Hospital Kissimmee Kissimmee Florida United States 34744
78 Lakeland Regional Cancer Center Lakeland Florida United States 33805
79 The Watson Clinic Lakeland Florida United States 33805
80 Jackson Memorial Hospital-Holtz Children's Hospital Miami Florida United States 33136
81 University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida United States 33136
82 South Miami Hospital Miami Florida United States 33143
83 Florida Hospital Orlando Orlando Florida United States 32803
84 Bay Medical Center Panama City Florida United States 32401
85 James A. Haley Veterans Affairs Hospital Tampa Florida United States 33612
86 Grady Health System Atlanta Georgia United States 30303
87 Piedmont Hospital Atlanta Georgia United States 30309
88 Emory University/Winship Cancer Institute Atlanta Georgia United States 30322
89 Northside Hospital Atlanta Georgia United States 30342
90 John B Amos Cancer Center Columbus Georgia United States 31904
91 Northside Hospital-Forsyth Cumming Georgia United States 30041
92 Atlanta VA Medical Center Decatur Georgia United States 30033
93 Piedmont Fayette Hospital Fayetteville Georgia United States 30214
94 Northeast Georgia Medical Center Gainesville Georgia United States 30501
95 Memorial University Medical Center Savannah Georgia United States 31404
96 Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah Georgia United States 31405
97 Queen's Medical Center Honolulu Hawaii United States 96813
98 University of Hawaii Cancer Center Honolulu Hawaii United States 96813
99 The Cancer Center of Hawaii-Liliha Honolulu Hawaii United States 96817
100 Saint Alphonsus Cancer Care Center-Boise Boise Idaho United States 83706
101 Idaho Urologic Institute-Meridian Meridian Idaho United States 83642
102 Kootenai Cancer Center Post Falls Idaho United States 83854
103 Saint Anthony's Health Alton Illinois United States 62002
104 Memorial Hospital of Carbondale Carbondale Illinois United States 62902
105 Northwestern University Chicago Illinois United States 60611
106 John H Stroger Jr Hospital of Cook County Chicago Illinois United States 60612-3785
107 University of Chicago Comprehensive Cancer Center Chicago Illinois United States 60637
108 Advocate Illinois Masonic Medical Center Chicago Illinois United States 60657
109 Decatur Memorial Hospital Decatur Illinois United States 62526
110 Crossroads Cancer Center Effingham Illinois United States 62401
111 Hines Veterans Administration Hospital Hines Illinois United States 60141
112 Loyola University Medical Center Maywood Illinois United States 60153
113 Pekin Cancer Treatment Center Pekin Illinois United States 61554
114 OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC Peoria Illinois United States 61615-7827
115 OSF Saint Francis Medical Center Peoria Illinois United States 61637
116 SwedishAmerican Regional Cancer Center/ACT Rockford Illinois United States 61114
117 Saint John's Hospital Springfield Illinois United States 62702
118 Memorial Medical Center Springfield Illinois United States 62781-0001
119 Memorial and Saint Elizabeth's Health Care Services LLP Swansea Illinois United States 62226
120 Saint Vincent Anderson Regional Hospital/Cancer Center Anderson Indiana United States 46016
121 IU Health West Hospital Avon Indiana United States 46123
122 IU Health Bloomington Bloomington Indiana United States 47403
123 Radiation Oncology Associates PC Fort Wayne Indiana United States 46804
124 Parkview Hospital Randallia Fort Wayne Indiana United States 46805
125 IU Health Goshen Center for Cancer Care Goshen Indiana United States 46526
126 Indiana University/Melvin and Bren Simon Cancer Center Indianapolis Indiana United States 46202
127 IU Health Methodist Hospital Indianapolis Indiana United States 46202
128 Richard L. Roudebush Veterans Affairs Medical Center Indianapolis Indiana United States 46202
129 IU Health Central Indiana Cancer Centers-East Indianapolis Indiana United States 46219
130 McFarland Clinic PC-William R Bliss Cancer Center Ames Iowa United States 50010
131 Medical Oncology and Hematology Associates-West Des Moines Clive Iowa United States 50325
132 Iowa Methodist Medical Center Des Moines Iowa United States 50309
133 Iowa Oncology Research Association CCOP Des Moines Iowa United States 50309
134 Medical Oncology and Hematology Associates-Des Moines Des Moines Iowa United States 50309
135 Medical Oncology and Hematology Associates-Laurel Des Moines Iowa United States 50314
136 Mercy Medical Center - Des Moines Des Moines Iowa United States 50314
137 Iowa Lutheran Hospital Des Moines Iowa United States 50316
138 Finley Hospital Dubuque Iowa United States 52001
139 Cancer Center of Kansas - Dodge City Dodge City Kansas United States 67801
140 Cancer Center of Kansas - El Dorado El Dorado Kansas United States 67042
141 Lawrence Memorial Hospital Lawrence Kansas United States 66044
142 Kansas City Cancer Centers-Southwest Overland Park Kansas United States 66210
143 Cancer Center of Kansas - Wellington Wellington Kansas United States 67152
144 Associates In Womens Health Wichita Kansas United States 67208
145 Cancer Center of Kansas-Wichita Medical Arts Tower Wichita Kansas United States 67208
146 Cancer Center of Kansas - Main Office Wichita Kansas United States 67214
147 Via Christi Regional Medical Center Wichita Kansas United States 67214
148 Wesley Medical Center Wichita Kansas United States 67214
149 Wichita CCOP Wichita Kansas United States 67214
150 Cancer Center of Kansas - Winfield Winfield Kansas United States 67156
151 Baptist Health Lexington Lexington Kentucky United States 40503
152 University of Kentucky/Markey Cancer Center Lexington Kentucky United States 40536
153 The James Graham Brown Cancer Center at University of Louisville Louisville Kentucky United States 40202
154 Owensboro Health Mitchell Memorial Cancer Center Owensboro Kentucky United States 42303
155 Mary Bird Perkins Cancer Center Baton Rouge Louisiana United States 70809
156 Tulane University Health Sciences Center New Orleans Louisiana United States 70112
157 Ochsner Medical Center Jefferson New Orleans Louisiana United States 70121
158 Central Maine Medical Center Lewiston Maine United States 04240
159 Maine Medical Center- Scarborough Campus Scarborough Maine United States 04074
160 Anne Arundel Medical Center Annapolis Maryland United States 21401
161 University of Maryland/Greenebaum Cancer Center Baltimore Maryland United States 21201
162 Greater Baltimore Medical Center Baltimore Maryland United States 21204
163 Saint Agnes Hospital Baltimore Maryland United States 21229
164 Upper Chesapeake Medical Center Bel Air Maryland United States 21015
165 Walter Reed National Military Medical Center Bethesda Maryland United States 20889-5600
166 Central Maryland Radiation Oncology in Howard County Columbia Maryland United States 21044
167 Tate Cancer Center Glen Burnie Maryland United States 21061
168 Holy Cross Hospital Silver Spring Maryland United States 20910
169 Massachusetts General Hospital Cancer Center Boston Massachusetts United States 02114
170 Boston Medical Center Boston Massachusetts United States 02118
171 Mass General/North Shore Cancer Center Danvers Massachusetts United States 01923
172 Saint Anne's Hospital Fall River Massachusetts United States 02721
173 Cape Cod Hospital Hyannis Massachusetts United States 02601
174 Lowell General Hospital Lowell Massachusetts United States 01854
175 Berkshire Hematology Oncology PC Pittsfield Massachusetts United States 01201
176 Beth Israel Deaconess Hospital-Plymouth Plymouth Massachusetts United States 02360
177 D'Amour Center for Cancer Care Springfield Massachusetts United States 01107
178 Baystate Medical Center Springfield Massachusetts United States 01199
179 Saint Vincent Hospital/Reliant Medical Group Worcester Massachusetts United States 01608
180 Bixby Medical Center Adrian Michigan United States 49221
181 Veteran's Administration Medical Center - Ann Arbor Ann Arbor Michigan United States 48105
182 Saint Joseph Mercy Hospital Ann Arbor Michigan United States 48106-0995
183 University of Michigan Comprehensive Cancer Center Ann Arbor Michigan United States 48109
184 Bronson Battle Creek Battle Creek Michigan United States 49017
185 McLaren-Bay Region Bay City Michigan United States 48708
186 Henry Ford Macomb Hospital Clinton Township Michigan United States 48038
187 Huron Valley-Sinai Hospital Commerce Michigan United States 48382
188 Henry Ford Hospital Detroit Michigan United States 48202
189 Saint John Hospital and Medical Center Detroit Michigan United States 48236
190 Green Bay Oncology - Escanaba Escanaba Michigan United States 49431
191 21st Century Oncology-Farmington Hills Farmington Hills Michigan United States 48334
192 Botsford General Hospital Farmington Michigan United States 48334
193 Genesys Hurley Cancer Institute Flint Michigan United States 48503
194 Genesys Regional Medical Center-West Flint Campus Flint Michigan United States 48532
195 McLaren-Flint Flint Michigan United States 48532
196 Mercy Health Saint Mary's Grand Rapids Michigan United States 49503
197 Spectrum Health at Butterworth Campus Grand Rapids Michigan United States 49503
198 Green Bay Oncology - Iron Mountain Iron Mountain Michigan United States 49801
199 Borgess Medical Center Kalamazoo Michigan United States 49001
200 Bronson Methodist Hospital Kalamazoo Michigan United States 49007
201 West Michigan Cancer Center Kalamazoo Michigan United States 49007
202 Sparrow Hospital Lansing Michigan United States 48912
203 Great Lakes Cancer Institute-Lapeer Campus Lapeer Michigan United States 48446
204 McLaren-Macomb Mount Clemens Michigan United States 48043
205 McLaren-Central Michigan Mount Pleasant Michigan United States 48858
206 Mercy Health Mercy Campus Muskegon Michigan United States 49444
207 McLaren Cancer Institute-Owosso Owosso Michigan United States 48867
208 Northern Michigan Regional Hospital Petoskey Michigan United States 49770
209 Saint Joseph Mercy Oakland Pontiac Michigan United States 48341
210 Saint Joseph Mercy Port Huron Port Huron Michigan United States 48060
211 Crittenton Hospital Rochester Michigan United States 48307
212 William Beaumont Hospital-Royal Oak Royal Oak Michigan United States 48073
213 Saint Mary's of Michigan Saginaw Michigan United States 48601
214 Downriver Center for Oncology Trenton Michigan United States 48183
215 21st Century Oncology-Troy Troy Michigan United States 48098
216 William Beaumont Hospital - Troy Troy Michigan United States 48098
217 Saint John Macomb-Oakland Hospital Warren Michigan United States 48093
218 Henry Ford West Bloomfield Hospital West Bloomfield Michigan United States 48322
219 Mayo Clinic Health System in Albert Lea Albert Lea Minnesota United States 56007
220 Sanford Clinic North-Bemidgi Bemidji Minnesota United States 56601
221 Miller-Dwan Hospital Duluth Minnesota United States 55805
222 Saint Luke's Hospital of Duluth Duluth Minnesota United States 55805
223 Fairview-Southdale Hospital Edina Minnesota United States 55435
224 Mayo Clinic Health Systems-Mankato Mankato Minnesota United States 56001
225 Mayo Clinic Rochester Minnesota United States 55905
226 Regions Hospital Saint Paul Minnesota United States 55101
227 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
228 Mercy Hospital-Joplin Joplin Missouri United States 64804
229 Kansas City Cancer Center - South Kansas City Missouri United States 64131
230 Kansas City Cancer Centers - North Kansas City Missouri United States 64154
231 Kansas City Cancer Center-Lee's Summit Lee's Summit Missouri United States 64064
232 Phelps County Regional Medical Center Rolla Missouri United States 65401
233 Washington University School of Medicine Saint Louis Missouri United States 63110
234 Siteman Cancer Center-South County Saint Louis Missouri United States 63129
235 Missouri Baptist Medical Center Saint Louis Missouri United States 63131
236 Barnes-Jewish West County Hospital Saint Louis Missouri United States 63141
237 Mercy Hospital Saint Louis Saint Louis Missouri United States 63141
238 Saint Louis-Cape Girardeau CCOP Saint Louis Missouri United States 63141
239 Siteman Cancer Center - Saint Peters Saint Peters Missouri United States 63376
240 Cancer Research for the Ozarks NCORP Springfield Missouri United States 65804
241 Mercy Hospital Springfield Springfield Missouri United States 65804
242 CoxHealth South Hospital Springfield Missouri United States 65807
243 Montana Cancer Consortium CCOP Billings Montana United States 59101
244 Northern Rockies Radiation Oncology Center Billings Montana United States 59101
245 Billings Clinic Cancer Center Billings Montana United States 59107
246 Berdeaux, Donald MD (UIA Investigator) Great Falls Montana United States 59405
247 Great Falls Clinic Great Falls Montana United States 59405
248 Saint Elizabeth Regional Medical Center Lincoln Nebraska United States 68510
249 Missouri Valley Cancer Consortium Omaha Nebraska United States 68106
250 Nebraska Methodist Hospital Omaha Nebraska United States 68114
251 Alegent Health Immanuel Medical Center Omaha Nebraska United States 68122
252 Alegent Health Bergan Mercy Medical Center Omaha Nebraska United States 68124
253 Alegent Health Lakeside Hospital Omaha Nebraska United States 68130
254 Creighton University Medical Center Omaha Nebraska United States 68131
255 University of Nebraska Medical Center Omaha Nebraska United States 68198
256 Concord Hospital Concord New Hampshire United States 03301
257 Exeter Hospital Exeter New Hampshire United States 03833
258 Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene New Hampshire United States 03431
259 Dartmouth Hitchcock Medical Center Lebanon New Hampshire United States 03756
260 Elliot Hospital Manchester New Hampshire United States 03103
261 Ocean Medical Center Brick New Jersey United States 08724
262 Cooper Hospital University Medical Center Camden New Jersey United States 08103
263 Veterans Adminstration New Jersey Health Care System East Orange New Jersey United States 07018-1095
264 CentraState Medical Center Freehold New Jersey United States 07728
265 Princeton Radiation Oncology Center Monroe New Jersey United States 08831
266 Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County Mount Holly New Jersey United States 08060
267 Jersey Shore Medical Center Neptune New Jersey United States 07753
268 Rutgers Cancer Institute of New Jersey New Brunswick New Jersey United States 08903
269 UMDNJ - Robert Wood Johnson University Hospital New Brunswick New Jersey United States 08903
270 UMDNJ - New Jersey Medical School Newark New Jersey United States 07103
271 Newark Beth Israel Medical Center Newark New Jersey United States 07112
272 The Medical Center At Princeton Princeton New Jersey United States 08540-3298
273 Riverview Medical Center/Booker Cancer Center Red Bank New Jersey United States 07701
274 Sparta Cancer Treatment Center Sparta New Jersey United States 07871
275 Community Medical Center Toms River New Jersey United States 08755
276 MD Anderson Cancer Center at Cooper-Voorhees Voorhees New Jersey United States 08043
277 Virtua West Jersey Hospital Voorhees Voorhees New Jersey United States 08043
278 Prostate Cancer Center of New Jersey West Orange New Jersey United States 07052
279 Lovelace Medical Center-Downtown Albuquerque New Mexico United States 87102
280 University of New Mexico Albuquerque New Mexico United States 87102
281 University of New Mexico Cancer Center Albuquerque New Mexico United States 87106
282 Radiation Oncology Associates Albuquerque New Mexico United States 87109
283 Memorial Medical Center - Las Cruces Las Cruces New Mexico United States 88011
284 New York Oncology Hematology PC - Albany Albany New York United States 12206
285 Saint Peters Hospital-Albany Albany New York United States 12208
286 Southside Hospital Bay Shore New York United States 11706
287 Lourdes Hospital Binghamton New York United States 13905
288 State University of New York Downstate Medical Center Brooklyn New York United States 11203
289 Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus Brooklyn New York United States 11209
290 Roswell Park Cancer Institute Buffalo New York United States 14263
291 Sands Cancer Center Canandaigua New York United States 14424
292 Mary Imogene Bassett Hospital Cooperstown New York United States 13326
293 Arnot Ogden Medical Center/Falck Cancer Center Elmira New York United States 14905
294 North Shore University Hospital Manhasset New York United States 11030
295 North Shore-LIJ Health System NCORP Manhasset New York United States 11030
296 Long Island Jewish Medical Center New Hyde Park New York United States 11040
297 North Shore-LIJ Health System/Center for Advanced Medicine New Hyde Park New York United States 11040
298 Columbia University Medical Center New York New York United States 10032
299 Hudson Valley Oncology Associates Poughkeepsie New York United States 12601
300 Highland Hospital Rochester New York United States 14620
301 University Radiation Oncology Rochester New York United States 14626
302 University of Rochester Rochester New York United States 14642
303 Randolph Hospital Asheboro North Carolina United States 27203
304 University of North Carolina at Chapel Hill Chapel Hill North Carolina United States 27599
305 Duke University Medical Center Durham North Carolina United States 27710
306 Cone Health Cancer Center Greensboro North Carolina United States 27403
307 The Coleman Radiation Center-Carteret General Hospital Morehead City North Carolina United States 28557
308 CarolinaEast Health System-Medical Center New Bern North Carolina United States 28560
309 Duke Cancer Institute Macon Pond Raleigh North Carolina United States 27607
310 Rex Cancer Center Raleigh North Carolina United States 27607
311 South Atlantic Radiation Oncology Supply North Carolina United States 28462
312 Coastal Carolina Radiation Oncology Wilmington North Carolina United States 28401
313 New Hanover Regional Medical Center/Zimmer Cancer Center Wilmington North Carolina United States 28401
314 Southeast Cancer Consortium-Upstate NCORP Winston-Salem North Carolina United States 27104
315 Mid Dakota Clinic Bismarck North Dakota United States 58501
316 Saint Alexius Medical Center Bismarck North Dakota United States 58501
317 Sanford Bismarck Medical Center Bismarck North Dakota United States 58501
318 Sanford Clinic North-Fargo Fargo North Dakota United States 58122
319 Sanford Medical Center-Fargo Fargo North Dakota United States 58122
320 Trinity Cancer Care Center Minot North Dakota United States 58701
321 Summa Akron City Hospital/Cooper Cancer Center Akron Ohio United States 44304
322 Akron General Medical Center Akron Ohio United States 44307
323 Summa Barberton Hospital Barberton Ohio United States 44203
324 UHHS-Chagrin Highlands Medical Center Beachwood Ohio United States 44122
325 Geaugra Hospital Chardon Ohio United States 44024
326 Adena Regional Medical Center Chillicothe Ohio United States 45601
327 University of Cincinnati Cincinnati Ohio United States 45267
328 Case Western Reserve University Cleveland Ohio United States 44106
329 Cleveland Clinic Cancer Center/Fairview Hospital Cleveland Ohio United States 44111
330 Cleveland Clinic Foundation Cleveland Ohio United States 44195
331 Ohio State University Comprehensive Cancer Center Columbus Ohio United States 43210
332 Riverside Methodist Hospital Columbus Ohio United States 43214
333 Columbus CCOP Columbus Ohio United States 43215
334 Grant Medical Center Columbus Ohio United States 43215
335 The Mark H Zangmeister Center Columbus Ohio United States 43219
336 Mount Carmel Health Center West Columbus Ohio United States 43222
337 Doctors Hospital Columbus Ohio United States 43228
338 Grady Memorial Hospital Delaware Ohio United States 43015
339 Mercy Cancer Center-Elyria Elyria Ohio United States 44035
340 Cleveland Clinic Cancer Center Independence Independence Ohio United States 44131
341 Marietta Memorial Hospital Marietta Ohio United States 45750
342 Toledo Clinic Cancer Centers-Maumee Maumee Ohio United States 43537
343 Hillcrest Hospital Cancer Center Mayfield Heights Ohio United States 44124
344 Summa Health Center at Lake Medina Medina Ohio United States 44256
345 Lake University Ireland Cancer Center Mentor Ohio United States 44060
346 Southwest General Health Center Ireland Cancer Center Middleburg Heights Ohio United States 44130
347 Licking Memorial Hospital Newark Ohio United States 43055
348 Saint Charles Hospital Oregon Ohio United States 43616
349 University Hospitals Parma Medical Center Parma Ohio United States 44129
350 Southern Ohio Medical Center Portsmouth Ohio United States 45662
351 Robinson Radiation Oncology Ravenna Ohio United States 44266
352 Cancer Care Center, Incorporated Salem Ohio United States 44460
353 Ireland Cancer Center at Firelands Regional Medical Center Sandusky Ohio United States 44870
354 North Coast Cancer Care Sandusky Ohio United States 44870
355 Flower Hospital Sylvania Ohio United States 43560
356 University of Toledo Toledo Ohio United States 43614
357 Mercy Saint Anne Hospital Toledo Ohio United States 43623
358 University Pointe West Chester Ohio United States 45069
359 Saint Ann's Hospital Westerville Ohio United States 43081
360 UHHS-Westlake Medical Center Westlake Ohio United States 44145
361 Cancer Treatment Center Wooster Ohio United States 44691
362 Cleveland Clinic Wooster Specialty Center Wooster Ohio United States 44691
363 Wright-Patterson Medical Center Wright-Patterson Air Force Base Ohio United States 45433-5529
364 Genesis HealthCare System Zanesville Ohio United States 43701
365 University of Oklahoma Health Sciences Center Oklahoma City Oklahoma United States 73104
366 Clackamas Radiation Oncology Center Clackamas Oregon United States 97015
367 Willamette Valley Cancer Center Eugene Oregon United States 97401
368 Three Rivers Community Hospital Grants Pass Oregon United States 97527
369 Legacy Mount Hood Medical Center Gresham Oregon United States 97030
370 Asante Health System Medford Oregon United States 97504
371 Providence Medford Medical Center Medford Oregon United States 97504
372 Rogue Valley Medical Center Medford Oregon United States 97504
373 Providence Milwaukie Hospital Milwaukie Oregon United States 97222
374 Legacy Good Samaritan Hospital and Medical Center Portland Oregon United States 97210
375 Providence Portland Medical Center Portland Oregon United States 97213
376 Western Oncology Research Consortium Portland Oregon United States 97213
377 Providence Saint Vincent Medical Center Portland Oregon United States 97225
378 Legacy Meridian Park Hospital Tualatin Oregon United States 97062
379 Abington Memorial Hospital Abington Pennsylvania United States 19001
380 Saint Luke's University Hospital-Bethlehem Campus Bethlehem Pennsylvania United States 18015
381 Bryn Mawr Hospital Bryn Mawr Pennsylvania United States 19010
382 Geisinger Medical Center Danville Pennsylvania United States 17822
383 Mercy Fitzgerald Hospital Darby Pennsylvania United States 19023-1291
384 Delaware County Memorial Hospital Drexel Hill Pennsylvania United States 19026
385 Northeast Radiation Oncology Center Dunmore Pennsylvania United States 18512
386 The Regional Cancer Center Erie Pennsylvania United States 16505
387 Fox Chase Cancer Center Buckingham Furlong Pennsylvania United States 18925
388 Adams Cancer Center Gettysburg Pennsylvania United States 17325
389 Cherry Tree Cancer Center Hanover Pennsylvania United States 17331
390 Penn State Milton S Hershey Medical Center Hershey Pennsylvania United States 17033-0850
391 Academic Urology Prostate Center King Of Prussia Pennsylvania United States 19406
392 Saint Mary Medical and Regional Cancer Center Langhorne Pennsylvania United States 19047
393 Upper Delaware Valley Cancer Center Milford Pennsylvania United States 18337
394 Paoli Memorial Hospital Paoli Pennsylvania United States 19301
395 Thomas Jefferson University Hospital Philadelphia Pennsylvania United States 19107
396 Fox Chase Cancer Center Philadelphia Pennsylvania United States 19111
397 Temple University Hospital Philadelphia Pennsylvania United States 19140
398 Albert Einstein Medical Center Philadelphia Pennsylvania United States 19141
399 VA Pittsburgh Healthcare System Pittsburgh Pennsylvania United States 15240
400 Reading Hospital West Reading Pennsylvania United States 19611
401 Lankenau Medical Center Wynnewood Pennsylvania United States 19096
402 Mainline Health CCOP Wynnewood Pennsylvania United States 19096
403 WellSpan Health-York Hospital York Pennsylvania United States 17405
404 AnMed Health Hospital Anderson South Carolina United States 29621
405 Medical University of South Carolina Charleston South Carolina United States 29425
406 Greenville Health System Cancer Institute-Faris Greenville South Carolina United States 29605
407 Greenville Health System Cancer Institute-Eastside Greenville South Carolina United States 29615
408 Self Regional Healthcare Greenwood South Carolina United States 29646
409 Greenville Health System Cancer Institute-Greer Greer South Carolina United States 29650
410 Gibbs Cancer Center-Pelham Greer South Carolina United States 29651
411 Carolina Regional Cancer Center Myrtle Beach South Carolina United States 29577
412 Greenville Health System Cancer Institute-Seneca Seneca South Carolina United States 29672
413 Spartanburg Medical Center Spartanburg South Carolina United States 29303
414 Greenville Health System Cancer Institute-Spartanburg Spartanburg South Carolina United States 29307
415 Rapid City Regional Hospital Rapid City South Dakota United States 57701
416 Wellmont Holston Valley Hospital and Medical Center Kingsport Tennessee United States 37660
417 Thompson Cancer Survival Center Knoxville Tennessee United States 37916
418 Blount Memorial Hospital Maryville Tennessee United States 37804
419 Texas Oncology-Arlington South Arlington Texas United States 76014
420 Texas Oncology-Austin Midtown Austin Texas United States 78705
421 Texas Oncology - Central Austin Cancer Center Austin Texas United States 78731
422 Texas Oncology - South Austin Cancer Center Austin Texas United States 78745
423 Texas Oncology Bedford Bedford Texas United States 76022
424 Texas Cancer Center - Medical City Dallas Dallas Texas United States 75230
425 Texas Oncology Methodist Charlton Cancer Center Dallas Texas United States 75237
426 UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas United States 75390
427 Texas Oncology-Denton South Denton Texas United States 76210
428 Brooke Army Medical Center Fort Sam Houston Texas United States 78234
429 The Klabzuba Cancer Center Fort Worth Texas United States 76104
430 University of Texas Medical Branch Galveston Texas United States 77555-0565
431 Memorial Hermann Memorial City Medical Center Houston Texas United States 77024
432 M D Anderson Cancer Center Houston Texas United States 77030
433 UTMB Cancer Center at Victory Lakes League City Texas United States 77573
434 Texas Oncology - Lewisville Lewisville Texas United States 75067
435 Texas Oncology-Longview Cancer Center Longview Texas United States 75601
436 West Texas Cancer Center Odessa Texas United States 79761
437 Texas Oncology-Seton Williamson Round Rock Texas United States 78665
438 Texas Oncology - Round Rock Cancer Center Round Rock Texas United States 78681
439 Texas Cancer Center-Sherman Sherman Texas United States 75090
440 Texas Oncology Cancer Center Sugar Land Sugar Land Texas United States 77479
441 Texas Oncology-Wichita Falls Texoma Cancer Center Wichita Falls Texas United States 76310
442 Sandra L Maxwell Cancer Center Cedar City Utah United States 84720
443 Intermountain Medical Center Murray Utah United States 84157
444 McKay-Dee Hospital Center Ogden Utah United States 84403
445 Utah Valley Regional Medical Center Provo Utah United States 84604
446 Dixie Medical Center Regional Cancer Center Saint George Utah United States 84770
447 Utah Cancer Specialists-Salt Lake City Salt Lake City Utah United States 84106
448 Huntsman Cancer Institute/University of Utah Salt Lake City Utah United States 84112
449 LDS Hospital Salt Lake City Utah United States 84143
450 Southwestern Vermont Medical Center Bennington Vermont United States 05201
451 Rutland Regional Medical Center Rutland Vermont United States 05701
452 Norris Cotton Cancer Center-North Saint Johnsbury Vermont United States 05819
453 Inova Alexandria Hospital Alexandria Virginia United States 22304
454 Danville Regional Medical Center Danville Virginia United States 24541
455 Augusta Health Cancer Center Fishersville Virginia United States 22939
456 Sentara Cancer Institute at Sentara CarePlex Hospital Hampton Virginia United States 23666
457 Sentara Rockingham Memorial Hospital Hahn Cancer Center Harrisonburg Virginia United States 22801
458 Sentara Hospitals Norfolk Virginia United States 23507
459 Southwest VA Regional Cancer Center Norton Virginia United States 24273
460 Naval Medical Center - Portsmouth Portsmouth Virginia United States 23708-2197
461 Oncology and Hematology Associates of Southwest Virginia Roanoke Virginia United States 24014
462 Sentara Virginia Beach General Hospital Virginia Beach Virginia United States 23454
463 PeaceHealth Saint Joseph Medical Center Bellingham Washington United States 98225
464 Saint Francis Hospital Federal Way Washington United States 98003
465 Virginia Mason CCOP Seattle Washington United States 98101
466 Virginia Mason Medical Center Seattle Washington United States 98101
467 Cancer Care Northwest - Spokane South Spokane Washington United States 99202
468 Cancer Care Northwest-North Spokane Spokane Washington United States 99218
469 PeaceHealth Southwest Medical Center Vancouver Washington United States 98664
470 Compass Oncology Vancouver Vancouver Washington United States 98684
471 Legacy Salmon Creek Hospital Vancouver Washington United States 98686
472 Appleton Medical Center Appleton Wisconsin United States 54911
473 Green Bay Oncology at Saint Vincent Hospital Green Bay Wisconsin United States 54301-3526
474 Bellin Memorial Hospital Green Bay Wisconsin United States 54301
475 Saint Vincent Hospital Green Bay Wisconsin United States 54301
476 Green Bay Oncology Limited at Saint Mary's Hospital Green Bay Wisconsin United States 54303
477 Saint Mary's Hospital Green Bay Wisconsin United States 54303
478 Aurora BayCare Medical Center Green Bay Wisconsin United States 54311-6519
479 UW Cancer Center Johnson Creek Johnson Creek Wisconsin United States 53038
480 Gundersen Lutheran Medical Center La Crosse Wisconsin United States 54601
481 Mayo Clinic Health System-Franciscan Healthcare La Crosse Wisconsin United States 54601
482 Bay Area Medical Center Marinette Wisconsin United States 54143
483 Vince Lombardi Cancer Clinic-Marinette Marinette Wisconsin United States 54143
484 Community Memorial Hospital Menomonee Falls Wisconsin United States 53051
485 Columbia Saint Mary's Hospital - Ozaukee Mequon Wisconsin United States 53097
486 Columbia Saint Mary's Water Tower Medical Commons Milwaukee Wisconsin United States 53211
487 Aurora Saint Luke's Medical Center Milwaukee Wisconsin United States 53215
488 Froedtert and the Medical College of Wisconsin Milwaukee Wisconsin United States 53226
489 Zablocki Veterans Administration Medical Center Milwaukee Wisconsin United States 53295
490 Green Bay Oncology - Oconto Falls Oconto Falls Wisconsin United States 54154
491 Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin United States 54904
492 Wheaton Franciscan Cancer Care - All Saints Racine Wisconsin United States 53405
493 Door County Cancer Center Sturgeon Bay Wisconsin United States 54235-1495
494 Green Bay Oncology - Sturgeon Bay Sturgeon Bay Wisconsin United States 54235
495 Aurora Medical Center in Summit Summit Wisconsin United States 53066
496 Aurora West Allis Medical Center West Allis Wisconsin United States 53227
497 The Alyce and Elmore Kraemer Cancer Care Center West Bend Wisconsin United States 53095
498 Riverview Hospital Wisconsin Rapids Wisconsin United States 54494
499 Welch Cancer Center Sheridan Wyoming United States 82801
500 Tom Baker Cancer Centre Calgary Alberta Canada T2N 4N2
501 Cross Cancer Institute Edmonton Alberta Canada T6G 1Z2
502 BCCA-Cancer Centre for the Southern Interior Kelowna British Columbia Canada V1Y 5L3
503 BCCA-Vancouver Island Cancer Centre Victoria British Columbia Canada V8R 6V5
504 Atlantic Health Sciences Corporation-Saint John Regional Hospital Saint John New Brunswick Canada E2L 4L2
505 QEII Health Sciences Centre/Capital District Health Authority Halifax Nova Scotia Canada B3H 1V8
506 Juravinski Cancer Centre at Hamilton Health Sciences Hamilton Ontario Canada L8V 5C2
507 London Regional Cancer Program London Ontario Canada N6A 4L6
508 Ottawa Health Research Institute-General Division Ottawa Ontario Canada K1H 1C4
509 Irving Greenberg Family Cancer Centre Ottawa Ontario Canada K2H 8P4
510 Thunder Bay Regional Health Science Centre Thunder Bay Ontario Canada P7B 6V4
511 Odette Cancer Centre- Sunnybrook Health Sciences Centre Toronto Ontario Canada M4N 3M5
512 Hopital Maisonneuve-Rosemont Montreal Quebec Canada H1T 2M4
513 CHUM - Hopital Notre-Dame Montreal Quebec Canada H2L 4M1
514 McGill University Department of Oncology Montreal Quebec Canada H2W 1S6
515 CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ) Quebec City Quebec Canada G1R 2J6
516 Centre Hospitalier Universitaire de Sherbrooke-Fleurimont Sherbrooke Quebec Canada J1H 5N4
517 Allan Blair Cancer Centre Regina Saskatchewan Canada S4T 7T1
518 Saskatoon Cancer Centre Saskatoon Saskatchewan Canada S7N 4H4

Sponsors and Collaborators

  • Radiation Therapy Oncology Group
  • National Cancer Institute (NCI)
  • NRG Oncology

Investigators

  • Study Chair: Alvaro A. Martinez, MD, FACR, 21st Century Oncology - Michigan Institute for Radiation Oncology

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Radiation Therapy Oncology Group
ClinicalTrials.gov Identifier:
NCT00936390
Other Study ID Numbers:
  • RTOG 0815
  • CDR0000648194
  • NCI-2011-01948
First Posted:
Jul 10, 2009
Last Update Posted:
Dec 26, 2017
Last Verified:
Dec 1, 2017

Study Results

No Results Posted as of Dec 26, 2017