BALANCE: BIOMARKER TRIAL of APALUTAMIDE and RADIATION for RECURRENT PROSTATE CANCER
Study Details
Study Description
Brief Summary
This phase II trial studies how well radiation therapy with or without apalutamide works in treating patients with stage III-IV prostate cancer. Radiation therapy uses high energy x-ray to kill tumor cells and shrink tumors. Androgen can cause the growth of prostate cancer cells. Drugs, such as apalutamide, may lessen the amount of androgen made by the body. Giving radiation therapy and apalutamide may work better at treating prostate cancer than radiation alone.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 2 |
Detailed Description
PRIMARY OBJECTIVES:
- To determine whether, in men with post-prostatectomy PSA recurrences, salvage radiation (SRT) with enhanced anti-androgen therapy with apalutamide will improve biochemical progression-free survival (bPFS) compared to SRT alone.
SECONDARY OBJECTIVES:
-
To assess whether molecular stratification by the PAM50 gene expression clustering will identify subsets of prostate cancer (luminal A or basal, luminal B) which derive the greatest benefit from anti-androgen therapy.
-
To assess overall survival. III. To assess cancer-specific mortality. IV. To assess metastasis-free survival. V. To assess distant metastasis. VI. To assess local-regional progression. VII. To assess PSA nadir during first year of treatment and prior to initiation of any hormonal salvage therapy.
-
To assess initiation of salvage hormonal therapy. IX. To assess PSA with a non-castrate testosterone at 1 and 3 years post randomization: PSA < 0.1 ng/ml and testosterone >= 50 ng/dl.
-
To assess acute and late physician-reported morbidity (per the Common Terminology Criteria for Adverse Events [CTCAE] version 5) after SRT +/- apalutamide.
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To assess acute and late patient-reported morbidity (per the patient reported outcomes [PRO]-CTCAE) after SRT +/- apalutamide.
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To assess testosterone levels at 3, 6, 9, 12, and 36 months post randomization.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM 1: Patients undergo external beam radiation therapy on Day 1 for 7.5 weeks. Beginning on Day 1 of radiation therapy, patients receive placebo orally (PO) once daily (QD) on days 1-30. Treatment repeats every 30 days for up to 6 courses (6 months) in the absence of disease progression or unacceptable toxicity.
ARM 2: Patients undergo external beam radiation therapy on Day 1 for 7.5 weeks. Beginning on Day 1 of radiation therapy, patients receive apalutamide PO QD on Days 1-30. Treatment repeats every 30 days for up to 6 courses (6 months) in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months for 2 years, then every 6 months for 3 years, and then yearly thereafter.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Placebo Comparator: Arm 1 (Radiation Therapy + Placebo) Patients undergo external beam radiation therapy on Day 1 for 7.5 weeks. Beginning on Day 1 of radiation therapy, patients receive placebo PO QD on Days 1-30. Treatment repeats every 30 days for up to 6 courses (6 months) in the absence of disease progression or unacceptable toxicity. |
Radiation: External Beam Radiation Therapy
Undergo external beam radiation therapy
Other Names:
Other: Placebo
Given PO
Other Names:
|
| Experimental: Arm 2 (Radiation Therapy + Apalutamide) Patients undergo external beam radiation therapy on Day 1 for 7.5 weeks. Beginning on Day 1 of radiation therapy, patients receive apalutamide PO QD on Days 1-30. Treatment repeats every 30 days for up to 6 courses (6 months)in the absence of disease progression or unacceptable toxicity. |
Drug: Apalutamide
Given PO
Other Names:
Radiation: External Beam Radiation Therapy
Undergo external beam radiation therapy
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Biochemical Progression-free survival (bPFS) [From randomization to the first occurrence of a rise in PSA, clinical or radiographic local, regional, or distant metastases, or death from any cause, assessed up to 6 years]
bPFS curves will be estimated by the Kaplan-Meier (1958) method and compared between the two treatment arms using a one-sided logrank test at the alpha = 0.12 significance level. Analysis will include evaluation of a potential predictive biomarker (molecular subtype) to inform the design of a subsequent, phase III clinical trial. In addition, a multivariable Cox (1972) regression model will be fit incorporating the three stratification factors used in the randomization (surgical margins, pre-salvage radiation (SRT) PSA, and molecular subtype) as covariates to estimate the adjusted hazard ratio (HR) between the two treatment groups. Additional regression models will be fit including other pretreatment characteristics as covariates.
Secondary Outcome Measures
- Acute Patient-Reported Morbidity (per the patient reported outcomes [PRO]- Common Terminology Criteria for Adverse Events [CTCAE]) [Up to 30 days after radiation therapy]
Adverse events will also be assessed using PRO-CTCAE items. Assessments will be collected before and at the end of radiotherapy treatment and in follow-up. For each symptom and each domain (i.e., frequency, severity, and interference), counts and frequencies will be provided for the worst score experienced by the patient by treatment arm. The proportion of patients with scores >= 1 and >= 3 will be compared between groups using a chi-square test, or Fisher's exact test if cell frequencies are < 5.
- Acute Physician-Reported Morbidity (per the Common Terminology Criteria for Adverse Events [CTCAE] version 5) [Up to 30 days after radiation therapy]
Adverse events will be scored according to the National Cancer Institute (NCI)'s CTCAE version 5.0. For each type of adverse event, frequencies will be provided for the worst grade experienced by the patient by treatment arm. The proportion of patients with grades >= 1 and >= 3 will be compared between groups using a chi-square test, or Fisher's exact test.
- Late Patient-Reported Morbidity (per the patient reported outcomes [PRO]- Common Terminology Criteria for Adverse Events [CTCAE]) [From the end of radiation therapy + 30 days up to 6 years]
Adverse events will also be assessed using PRO-CTCAE items. Assessments will be collected before and at the end of radiotherapy treatment and in follow-up. For each symptom and each domain (i.e., frequency, severity, and interference), counts and frequencies will be provided for the worst score experienced by the patient by treatment arm. The proportion of patients with scores >= 1 and >= 3 will be compared between groups using a chi-square test, or Fisher's exact test if cell frequencies are < 5.
- Late Physician-Reported Morbidity (per the Common Terminology Criteria for Adverse Events [CTCAE] version 4) defined as grade 3+ adverse events occurring more than 30 days after the completion of radiation therapy [From the end of radiation therapy + 30 days to the time of the first recorded late grade 3+ adverse event, assessed up to 6 years]
Adverse events will be scored according to the NCI's CTCAE version 5.0. For each type of adverse event, counts and frequencies will be provided for the worst grade experienced by the patient by treatment arm. The proportion of patients with grades >= 1 and >= 3 will be compared between groups using a chi-square test, or Fisher's exact test.
- Cancer-Specific Mortality (CSM) [From the date of randomization to the date of death due to prostate cancer, assessed up to 6 years]
CSM will be estimated by the Kaplan-Meier method and compared between treatment arms via the logrank test. Patients dying from other causes will be censored as of the date of death. Cox regression will be used to obtain HRs for this outcome, both unadjusted and adjusted for covariates. A competing risks analysis will also be performed treating death from prostate cancer and death from all other causes as competing risks. Cumulative incidence curves will be generated (Gooley et al., 1999; Dignam et al., 2004) along with 95% confidence intervals and compared between the two treatment arms using Gray's method (Gray, 1988).
- Distant Metastasis [Up to 6 years]
Will also be analyzed under a competing risks framework, treating death without experiencing the event in question as a competing risk.
- Initiation of Salvage Hormonal Therapy [Up to 6 years]
Will also be analyzed under a competing risks framework, treating death without experiencing the event in question as a competing risk.
- Local-Regional Progression [From randomization to local or regional recurrence, assessed up to 6 years]
Will also be analyzed under a competing risks framework, treating death without experiencing the event in question as a competing risk.
- Metastasis-Free Survival (MFS) [From randomization until distant metastasis (clinical and/or radiographic appearance of disseminated disease) or death from any cause, assessed up to 6 years]
MFS will be estimated by the Kaplan-Meier method and compared between treatment arms via the logrank test. Cox regression will be used to obtain HRs for this outcome, both unadjusted and adjusted for covariates.
- Overall survival (OS) [From randomization until death from any cause, assessed up to 6 years]
OS will be estimated by the Kaplan-Meier method and compared between treatment arms via the logrank test. Cox regression will be used to obtain HRs for this outcome, both unadjusted and adjusted for covariates.
- PSA Nadir During First Year of Treatment and Prior to Initiation of any Hormonal Salvage Therapy [During first year of treatment]
Will be compared between the two groups using a two-sample t-test.
- Testosterone Levels [Every 3 months until 36 months post randomization]
Testosterone levels over time will be assessed using mixed effects regression modeling.
- Undetectable PSA with a Non-Castrate Testosterone (PSA < 0.1 ng/ml and testosterone >= 50 ng/dl) [1 year]
The proportion of patients with undetectable PSA and non-castrate testosterone level will be compared between the two treatment arms using chi square tests.
- Undetectable PSA with a Non-Castrate testosterone (PSA < 0.1 ng/ml and testosterone >= 50 ng/dl)) [3 years]
The proportion of patients with undetectable PSA and non-castrate testosterone level will be compared between the two treatment arms using chi square tests.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Pathologically (histologically) proven diagnosis of prostate adenocarcinoma; prostatectomy must have been performed within 10 years prior to Step 1 registration and any type of radical prostatectomy is permitted, including retropubic, perineal, laparoscopic or robotically assisted
-
Post-prostatectomy patients with a detectable serum PSA (≥ 0.1, but ≤ 1.0 ng/mL) at study entry (within 90 days of Step 1 registration) and at least one of the following:
-
Gleason score 7-10 (International Society of Urological Pathology [ISUP] grade group 2 to 5)
-
ISUP grade group:
-
Grade Group 1: Gleason score ≤ 6,
-
Grade Group 2: Gleason score 3 + 4 = 7,
-
Grade Group 3: Gleason score 4 + 3 = 7,
-
Grade Group 4: Gleason score 8,
-
Grade Group 5: Gleason scores 9 and 10
-
= T3a disease
-
Persistent elevation of PSA after prostatectomy measured within 90 days after surgery (PSA never became undetectable) of > 0.04 but < 0.2 ng/mL (PSA nadir)
-
pN0 or pNx
-
History/physical examination within 90 days prior to Step 1 registration
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Karnofsky performance status of 70-100 within 90 days prior to Step 1 registration
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Surgical formalin-fixed paraffin-embedded (FFPE) specimen must be available for submission to GenomeDx for genomic analysis on Decipher GRID platform; Note: if Decipher results have already been obtained, in lieu of tissue, results must be submitted to GenomeDx for validation
-
Prior androgen deprivation therapy (luteinizing hormone-releasing hormone [LHRH] agonist and/or non-steroidal anti-androgen) is allowed if discontinued at least 90 days prior to Step 1 registration and given for ≤ 90 days duration
-
For example: patients on prior LHRH analogs (post-prostatectomy), the discontinuation date should be calculated based on the expected duration of the sustained release injection, not simply the injection date of the drug; for instance, if a 22.5 mg sustained release dose of leuprolide acetate is given (3 month duration), then the expected duration of such a dose would be 90 days after the injection date; for a 7.5 mg leuprolide (1 month duration), the discontinuation date would be 30 days after the injection date
-
Please note: finasteride or dutasteride must be stopped before treatment starts but prior usage will not affect eligibility
-
Hemoglobin ≥ 9.0 g/dL, independent of transfusion and/or growth factors within 90 days prior to Step 1 registration
-
Platelet count ≥ 100,000 x 10^9/uL independent of transfusion and/or growth factors within 90 days prior to step 1 registration
-
Serum albumin ≥ 3.0 g/dL within 90 days prior to Step 1 registration
-
Glomerular filtration rate (GFR) ≥ 35 mL/min estimated by Cockcroft-Gault or measured directly by 24 hour urine creatinine within 90 days prior to Step 1 registration
-
Serum total bilirubin ≤ 1.5 x upper limit of normal (ULN) (Note: in subjects with Gilbert's syndrome, if total bilirubin is > 1.5 x ULN, measure direct and indirect bilirubin and if direct bilirubin is ≤ 1.5 x ULN, subject is eligible) within 90 days prior to Step 1 registration
-
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 2.5 x ULN within 90 days prior to Step 1 registration
-
Testosterone > 50 ng/dL within 90 days prior to Step 1 registration
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Concomitant medications known to lower the seizure threshold discontinued or substituted at least 4 weeks (30 days) prior to Step 1 registration.
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The patient must agree to use a condom (even men with vasectomies) and another effective method of birth control if he is having sex with a woman of childbearing potential or agree to use a condom if he is having sex with a woman who is pregnant while on study drug and for 3 months following the last dose of study drug
-
The patient must agree not to donate sperm during the study treatment and for 3 months after receiving the last dose of study drug
-
The patient or a legally authorized representative must provide study-specific informed consent prior to study entry
Exclusion Criteria:
-
Definitive clinical, radiologic, or pathologic evidence of metastatic disease (M1) or lymph node involvement (N1)
-
Prior invasive malignancy (except non-melanomatous skin cancer, carcinoma in situ of the male breast, penis, oral cavity, or stage Ta of the bladder, or stage I completely resected melanoma) unless disease free for a minimum of 2 years
-
Prior systemic chemotherapy for the study cancer; note that prior chemotherapy for a different cancer is allowable
-
Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields
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History of any of the following:
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Seizure or known condition that may pre-dispose to seizure (e.g. prior stroke within 1 year prior to Step 1 registration)
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History of documented inflammatory bowel disease
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Transmural myocardial infarction within the last 4 months prior to Step 1 registration.
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Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months prior to Step 1 registration
-
History of any condition that in the opinion of the investigator, would preclude participation in this study
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Current evidence of any of the following:
-
Known gastrointestinal disorder affecting absorption of oral medications
-
Active uncontrolled infection (eg, human immunodeficiency virus [HIV] or viral hepatitis)
-
Uncontrolled hypertension
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Any current condition that in the opinion of the investigator, would preclude participation in this study
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Prior whole gland ablative therapy (i.e. cryoablation or high intensity focused ultrasound [HIFU]) for prostate cancer is not allowed
-
HIV positive with CD4 count < 200 cells/microliter within 30 days prior to registration
-
HIV patients under treatment with highly active antiretroviral therapy (HAART) within 30 days prior to registration regardless of CD4 count. (Note: HIV testing is not required for eligibility for this protocol as it is self-reported.)
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For patients who have not undergone prior Decipher analysis, submission of the specimen to GenomeDx should be as soon as possible after study registration (Step 1) as these results can take up 21 days after the specimen is received at GenomeDx; Step 2 registration must occur within 6 weeks (42 days) of Step 1 registration; if Decipher results have already been obtained, in lieu of tissue, results must be submitted to GenomeDx for validation
-
Patients must not plan to participate in any other clinical trials while receiving treatment on this study or being followed post-protocol therapy.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Arizona Breast Cancer Specialists-Gilbert | Gilbert | Arizona | United States | 85297 |
| 2 | Arizona Center for Cancer Care-Peoria | Peoria | Arizona | United States | 85381 |
| 3 | Arizona Breast Cancer Specialists-Scottsdale | Scottsdale | Arizona | United States | 85258 |
| 4 | Arizona Center for Cancer Care-Surprise | Surprise | Arizona | United States | 85374 |
| 5 | University of Arkansas for Medical Sciences | Little Rock | Arkansas | United States | 72205 |
| 6 | Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California | United States | 94704 |
| 7 | Marin General Hospital | Greenbrae | California | United States | 94904 |
| 8 | Los Angeles County-USC Medical Center | Los Angeles | California | United States | 90033 |
| 9 | USC / Norris Comprehensive Cancer Center | Los Angeles | California | United States | 90033 |
| 10 | Cedars Sinai Medical Center | Los Angeles | California | United States | 90048 |
| 11 | Sutter Cancer Centers Radiation Oncology Services-Roseville | Roseville | California | United States | 95661 |
| 12 | Sutter Medical Center Sacramento | Sacramento | California | United States | 95816 |
| 13 | University of California Davis Comprehensive Cancer Center | Sacramento | California | United States | 95817 |
| 14 | Gene Upshaw Memorial Tahoe Forest Cancer Center | Truckee | California | United States | 96161 |
| 15 | Sutter Solano Medical Center/Cancer Center | Vallejo | California | United States | 94589 |
| 16 | University of Colorado Hospital | Aurora | Colorado | United States | 80045 |
| 17 | Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | United States | 80907 |
| 18 | UCHealth Memorial Hospital Central | Colorado Springs | Colorado | United States | 80909 |
| 19 | Memorial Hospital North | Colorado Springs | Colorado | United States | 80920 |
| 20 | Poudre Valley Hospital | Fort Collins | Colorado | United States | 80524 |
| 21 | Cancer Care and Hematology-Fort Collins | Fort Collins | Colorado | United States | 80528 |
| 22 | Valley View Hospital Cancer Center | Glenwood Springs | Colorado | United States | 81601 |
| 23 | UCHealth Greeley Hospital | Greeley | Colorado | United States | 80631 |
| 24 | Medical Center of the Rockies | Loveland | Colorado | United States | 80538 |
| 25 | Stamford Hospital/Bennett Cancer Center | Stamford | Connecticut | United States | 06904 |
| 26 | Helen F Graham Cancer Center | Newark | Delaware | United States | 19713 |
| 27 | Christiana Care Health System-Christiana Hospital | Newark | Delaware | United States | 19718 |
| 28 | Beebe Health Campus | Rehoboth Beach | Delaware | United States | 19971 |
| 29 | George Washington University Medical Center | Washington | District of Columbia | United States | 20037 |
| 30 | AdventHealth Altamonte | Altamonte Springs | Florida | United States | 32701 |
| 31 | Regional Cancer Center-Lee Memorial Health System | Fort Myers | Florida | United States | 33905 |
| 32 | AdventHealth Kissimmee | Kissimmee | Florida | United States | 34744 |
| 33 | AdventHealth Orlando | Orlando | Florida | United States | 32803 |
| 34 | AdventHealth East Orlando | Orlando | Florida | United States | 32822 |
| 35 | Cleveland Clinic-Weston | Weston | Florida | United States | 33331 |
| 36 | AdventHealth Winter Park | Winter Park | Florida | United States | 32792 |
| 37 | Grady Health System | Atlanta | Georgia | United States | 30303 |
| 38 | Emory University Hospital Midtown | Atlanta | Georgia | United States | 30308 |
| 39 | Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | United States | 30322 |
| 40 | Emory Saint Joseph's Hospital | Atlanta | Georgia | United States | 30342 |
| 41 | Northside Hospital | Atlanta | Georgia | United States | 30342 |
| 42 | Augusta University Medical Center | Augusta | Georgia | United States | 30912 |
| 43 | Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia | United States | 31405 |
| 44 | Saint Luke's Cancer Institute - Boise | Boise | Idaho | United States | 83712 |
| 45 | Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | United States | 83619 |
| 46 | Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | United States | 83642 |
| 47 | Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | United States | 83686 |
| 48 | Saint Luke's Cancer Institute - Twin Falls | Twin Falls | Idaho | United States | 83301 |
| 49 | Rush University Medical Center | Chicago | Illinois | United States | 60612 |
| 50 | University of Illinois | Chicago | Illinois | United States | 60612 |
| 51 | Decatur Memorial Hospital | Decatur | Illinois | United States | 62526 |
| 52 | Crossroads Cancer Center | Effingham | Illinois | United States | 62401 |
| 53 | Edward Hines Jr VA Hospital | Hines | Illinois | United States | 60141 |
| 54 | Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
| 55 | Illinois CancerCare-Peoria | Peoria | Illinois | United States | 61615 |
| 56 | OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria | Illinois | United States | 61615 |
| 57 | OSF Saint Francis Medical Center | Peoria | Illinois | United States | 61637 |
| 58 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62702 |
| 59 | Springfield Clinic | Springfield | Illinois | United States | 62702 |
| 60 | Memorial Medical Center | Springfield | Illinois | United States | 62781 |
| 61 | Carle Cancer Center | Urbana | Illinois | United States | 61801 |
| 62 | Parkview Hospital Randallia | Fort Wayne | Indiana | United States | 46805 |
| 63 | Parkview Regional Medical Center | Fort Wayne | Indiana | United States | 46845 |
| 64 | Goshen Center for Cancer Care | Goshen | Indiana | United States | 46526 |
| 65 | Reid Health | Richmond | Indiana | United States | 47374 |
| 66 | Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa | United States | 50325 |
| 67 | Mercy Cancer Center-West Lakes | Clive | Iowa | United States | 50325 |
| 68 | Greater Regional Medical Center | Creston | Iowa | United States | 50801 |
| 69 | Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa | United States | 50314 |
| 70 | Mercy Medical Center - Des Moines | Des Moines | Iowa | United States | 50314 |
| 71 | Mercy Medical Center-West Lakes | West Des Moines | Iowa | United States | 50266 |
| 72 | University of Kansas Cancer Center | Kansas City | Kansas | United States | 66160 |
| 73 | Olathe Health Cancer Center | Olathe | Kansas | United States | 66061 |
| 74 | University of Kansas Cancer Center-Overland Park | Overland Park | Kansas | United States | 66210 |
| 75 | Salina Regional Health Center | Salina | Kansas | United States | 67401 |
| 76 | University of Kansas Hospital-Westwood Cancer Center | Westwood | Kansas | United States | 66205 |
| 77 | University of Kentucky/Markey Cancer Center | Lexington | Kentucky | United States | 40536 |
| 78 | Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | United States | 70809 |
| 79 | East Jefferson General Hospital | Metairie | Louisiana | United States | 70006 |
| 80 | LSU Healthcare Network / Metairie Multi-Specialty Clinic | Metairie | Louisiana | United States | 70006 |
| 81 | MaineHealth Coastal Cancer Treatment Center | Bath | Maine | United States | 04530 |
| 82 | Waldo County General Hospital | Belfast | Maine | United States | 04915 |
| 83 | MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford | Biddeford | Maine | United States | 04005 |
| 84 | Lafayette Family Cancer Center-EMMC | Brewer | Maine | United States | 04412 |
| 85 | Stephens Memorial Hospital | Norway | Maine | United States | 04268 |
| 86 | Maine Medical Center-Bramhall Campus | Portland | Maine | United States | 04102 |
| 87 | Penobscot Bay Medical Center | Rockport | Maine | United States | 04856 |
| 88 | MaineHealth Cancer Care Center of York County | Sanford | Maine | United States | 04073 |
| 89 | MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford | Sanford | Maine | United States | 04073 |
| 90 | Maine Medical Center- Scarborough Campus | Scarborough | Maine | United States | 04074 |
| 91 | Maine Medical Partners - South Portland | South Portland | Maine | United States | 04106 |
| 92 | University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | United States | 21201 |
| 93 | Saint Agnes Hospital | Baltimore | Maryland | United States | 21229 |
| 94 | Central Maryland Radiation Oncology in Howard County | Columbia | Maryland | United States | 21044 |
| 95 | UM Baltimore Washington Medical Center/Tate Cancer Center | Glen Burnie | Maryland | United States | 21061 |
| 96 | Lahey Hospital and Medical Center | Burlington | Massachusetts | United States | 01805 |
| 97 | Lowell General Hospital | Lowell | Massachusetts | United States | 01854 |
| 98 | Saint Joseph Mercy Hospital | Ann Arbor | Michigan | United States | 48106 |
| 99 | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | United States | 48109 |
| 100 | Bronson Battle Creek | Battle Creek | Michigan | United States | 49017 |
| 101 | Saint Joseph Mercy Brighton | Brighton | Michigan | United States | 48114 |
| 102 | Saint Joseph Mercy Canton | Canton | Michigan | United States | 48188 |
| 103 | Saint Joseph Mercy Chelsea | Chelsea | Michigan | United States | 48118 |
| 104 | GenesisCare USA - Clarkston | Clarkston | Michigan | United States | 48346 |
| 105 | Henry Ford Macomb Hospital-Clinton Township | Clinton Township | Michigan | United States | 48038 |
| 106 | Beaumont Hospital - Dearborn | Dearborn | Michigan | United States | 48124 |
| 107 | Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
| 108 | Michigan State University Clinical Center | East Lansing | Michigan | United States | 48824-7016 |
| 109 | GenesisCare USA - Farmington Hills | Farmington Hills | Michigan | United States | 48334 |
| 110 | Mercy Health Saint Mary's | Grand Rapids | Michigan | United States | 49503 |
| 111 | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | United States | 49503 |
| 112 | West Michigan Cancer Center | Kalamazoo | Michigan | United States | 49007 |
| 113 | Sparrow Hospital | Lansing | Michigan | United States | 48912 |
| 114 | Lakeland Hospital Niles | Niles | Michigan | United States | 49120 |
| 115 | Spectrum Health Reed City Hospital | Reed City | Michigan | United States | 49677 |
| 116 | William Beaumont Hospital-Royal Oak | Royal Oak | Michigan | United States | 48073 |
| 117 | Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan | United States | 49085 |
| 118 | Marie Yeager Cancer Center | Saint Joseph | Michigan | United States | 49085 |
| 119 | Munson Medical Center | Traverse City | Michigan | United States | 49684 |
| 120 | William Beaumont Hospital - Troy | Troy | Michigan | United States | 48085 |
| 121 | GenesisCare USA - Troy | Troy | Michigan | United States | 48098 |
| 122 | Henry Ford West Bloomfield Hospital | West Bloomfield | Michigan | United States | 48322 |
| 123 | Metro Health Hospital | Wyoming | Michigan | United States | 49519 |
| 124 | Mayo Clinic Health System in Albert Lea | Albert Lea | Minnesota | United States | 56007 |
| 125 | Fairview Ridges Hospital | Burnsville | Minnesota | United States | 55337 |
| 126 | Mercy Hospital | Coon Rapids | Minnesota | United States | 55433 |
| 127 | Fairview Southdale Hospital | Edina | Minnesota | United States | 55435 |
| 128 | Unity Hospital | Fridley | Minnesota | United States | 55432 |
| 129 | Mayo Clinic Health Systems-Mankato | Mankato | Minnesota | United States | 56001 |
| 130 | Fairview Clinics and Surgery Center Maple Grove | Maple Grove | Minnesota | United States | 55369 |
| 131 | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | United States | 55109 |
| 132 | Saint John's Hospital - Healtheast | Maplewood | Minnesota | United States | 55109 |
| 133 | Abbott-Northwestern Hospital | Minneapolis | Minnesota | United States | 55407 |
| 134 | Hennepin County Medical Center | Minneapolis | Minnesota | United States | 55415 |
| 135 | Minneapolis VA Medical Center | Minneapolis | Minnesota | United States | 55417 |
| 136 | Health Partners Inc | Minneapolis | Minnesota | United States | 55454 |
| 137 | Monticello Cancer Center | Monticello | Minnesota | United States | 55362 |
| 138 | North Memorial Medical Health Center | Robbinsdale | Minnesota | United States | 55422 |
| 139 | Mayo Clinic in Rochester | Rochester | Minnesota | United States | 55905 |
| 140 | Coborn Cancer Center at Saint Cloud Hospital | Saint Cloud | Minnesota | United States | 56303 |
| 141 | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | United States | 55416 |
| 142 | Regions Hospital | Saint Paul | Minnesota | United States | 55101 |
| 143 | United Hospital | Saint Paul | Minnesota | United States | 55102 |
| 144 | Saint Francis Regional Medical Center | Shakopee | Minnesota | United States | 55379 |
| 145 | Lakeview Hospital | Stillwater | Minnesota | United States | 55082 |
| 146 | Ridgeview Medical Center | Waconia | Minnesota | United States | 55387 |
| 147 | Rice Memorial Hospital | Willmar | Minnesota | United States | 56201 |
| 148 | Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | United States | 55125 |
| 149 | Fairview Lakes Medical Center | Wyoming | Minnesota | United States | 55092 |
| 150 | University of Mississippi Medical Center | Jackson | Mississippi | United States | 39216 |
| 151 | Southeast Cancer Center | Cape Girardeau | Missouri | United States | 63703 |
| 152 | Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | United States | 63141 |
| 153 | Capital Region Southwest Campus | Jefferson City | Missouri | United States | 65109 |
| 154 | Kansas City Veterans Affairs Medical Center | Kansas City | Missouri | United States | 64128 |
| 155 | University of Kansas Cancer Center - North | Kansas City | Missouri | United States | 64154 |
| 156 | University of Kansas Cancer Center - Lee's Summit | Lee's Summit | Missouri | United States | 64064 |
| 157 | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | United States | 65401 |
| 158 | Washington University School of Medicine | Saint Louis | Missouri | United States | 63110 |
| 159 | Siteman Cancer Center-South County | Saint Louis | Missouri | United States | 63129 |
| 160 | Mercy Hospital Saint Louis | Saint Louis | Missouri | United States | 63141 |
| 161 | Siteman Cancer Center at Saint Peters Hospital | Saint Peters | Missouri | United States | 63376 |
| 162 | Billings Clinic Cancer Center | Billings | Montana | United States | 59101 |
| 163 | Bozeman Deaconess Hospital | Bozeman | Montana | United States | 59715 |
| 164 | Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | United States | 59405 |
| 165 | Nebraska Methodist Hospital | Omaha | Nebraska | United States | 68114 |
| 166 | Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska | United States | 68124 |
| 167 | University of Nebraska Medical Center | Omaha | Nebraska | United States | 68198 |
| 168 | Comprehensive Cancer Centers of Nevada - Henderson | Henderson | Nevada | United States | 89052 |
| 169 | Comprehensive Cancer Centers of Nevada-Horizon Ridge | Henderson | Nevada | United States | 89052 |
| 170 | Las Vegas Cancer Center-Henderson | Henderson | Nevada | United States | 89052 |
| 171 | OptumCare Cancer Care at Seven Hills | Henderson | Nevada | United States | 89052 |
| 172 | 21st Century Oncology-Henderson | Henderson | Nevada | United States | 89074 |
| 173 | Comprehensive Cancer Centers of Nevada-Southeast Henderson | Henderson | Nevada | United States | 89074 |
| 174 | Desert West Surgery | Las Vegas | Nevada | United States | 89102 |
| 175 | OptumCare Cancer Care at Charleston | Las Vegas | Nevada | United States | 89102 |
| 176 | University Medical Center of Southern Nevada | Las Vegas | Nevada | United States | 89102 |
| 177 | Hope Cancer Care of Nevada | Las Vegas | Nevada | United States | 89103 |
| 178 | Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada | United States | 89106 |
| 179 | 21st Century Oncology | Las Vegas | Nevada | United States | 89109 |
| 180 | HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway | Las Vegas | Nevada | United States | 89109 |
| 181 | HealthCare Partners Medical Group Oncology/Hematology-San Martin | Las Vegas | Nevada | United States | 89113 |
| 182 | Radiation Oncology Centers of Nevada Southeast | Las Vegas | Nevada | United States | 89119 |
| 183 | Cancer Therapy and Integrative Medicine | Las Vegas | Nevada | United States | 89121 |
| 184 | 21st Century Oncology-Vegas Tenaya | Las Vegas | Nevada | United States | 89128 |
| 185 | Ann M Wierman MD LTD | Las Vegas | Nevada | United States | 89128 |
| 186 | Comprehensive Cancer Centers of Nevada - Northwest | Las Vegas | Nevada | United States | 89128 |
| 187 | HealthCare Partners Medical Group Oncology/Hematology-Tenaya | Las Vegas | Nevada | United States | 89128 |
| 188 | OptumCare Cancer Care at MountainView | Las Vegas | Nevada | United States | 89128 |
| 189 | Comprehensive Cancer Centers of Nevada-Summerlin | Las Vegas | Nevada | United States | 89144 |
| 190 | Summerlin Hospital Medical Center | Las Vegas | Nevada | United States | 89144 |
| 191 | Las Vegas Cancer Center-Medical Center | Las Vegas | Nevada | United States | 89148-2405 |
| 192 | 21st Century Oncology-Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 193 | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | United States | 89148 |
| 194 | OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 195 | HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills | Las Vegas | Nevada | United States | 89149 |
| 196 | Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada | United States | 89169 |
| 197 | University Cancer Center | Las Vegas | Nevada | United States | 89169 |
| 198 | Hope Cancer Care of Nevada-Pahrump | Pahrump | Nevada | United States | 89048 |
| 199 | Radiation Oncology Associates | Reno | Nevada | United States | 89509 |
| 200 | New Hampshire Oncology Hematology PA-Concord | Concord | New Hampshire | United States | 03301 |
| 201 | Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | United States | 03756 |
| 202 | Solinsky Center for Cancer Care | Manchester | New Hampshire | United States | 03103 |
| 203 | Virtua Memorial | Mount Holly | New Jersey | United States | 08060 |
| 204 | Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | United States | 08903 |
| 205 | Sidney Kimmel Cancer Center Washington Township | Sewell | New Jersey | United States | 08080 |
| 206 | Robert Wood Johnson University Hospital Somerset | Somerville | New Jersey | United States | 08876 |
| 207 | University of New Mexico Cancer Center | Albuquerque | New Mexico | United States | 87102 |
| 208 | New Mexico Oncology Hematology Consultants | Albuquerque | New Mexico | United States | 87109 |
| 209 | James J Peters VA Medical Center | Bronx | New York | United States | 10468 |
| 210 | New York-Presbyterian/Brooklyn Methodist Hospital | Brooklyn | New York | United States | 11215 |
| 211 | Sands Cancer Center | Canandaigua | New York | United States | 14424 |
| 212 | Mary Imogene Bassett Hospital | Cooperstown | New York | United States | 13326 |
| 213 | Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York | United States | 10016 |
| 214 | Wilmot Cancer Institute Radiation Oncology at Greece | Rochester | New York | United States | 14606 |
| 215 | Highland Hospital | Rochester | New York | United States | 14620 |
| 216 | University of Rochester | Rochester | New York | United States | 14642 |
| 217 | Stony Brook University Medical Center | Stony Brook | New York | United States | 11794 |
| 218 | State University of New York Upstate Medical University | Syracuse | New York | United States | 13210 |
| 219 | UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina | United States | 27599 |
| 220 | NHRMC Radiation Oncology - Supply | Supply | North Carolina | United States | 28462 |
| 221 | New Hanover Regional Medical Center/Zimmer Cancer Center | Wilmington | North Carolina | United States | 28401 |
| 222 | NHRMC Radiation Oncology - 16th Street | Wilmington | North Carolina | United States | 28401 |
| 223 | Summa Health System - Akron Campus | Akron | Ohio | United States | 44304 |
| 224 | Cleveland Clinic Akron General | Akron | Ohio | United States | 44307 |
| 225 | UHHS-Chagrin Highlands Medical Center | Beachwood | Ohio | United States | 44122 |
| 226 | Indu and Raj Soin Medical Center | Beavercreek | Ohio | United States | 45431 |
| 227 | Dayton Physicians LLC-Miami Valley South | Centerville | Ohio | United States | 45459 |
| 228 | Miami Valley Hospital South | Centerville | Ohio | United States | 45459 |
| 229 | Geauga Hospital | Chardon | Ohio | United States | 44024 |
| 230 | University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | United States | 45219 |
| 231 | Oncology Hematology Care Inc-Kenwood | Cincinnati | Ohio | United States | 45236 |
| 232 | Case Western Reserve University | Cleveland | Ohio | United States | 44106 |
| 233 | Cleveland Clinic Cancer Center/Fairview Hospital | Cleveland | Ohio | United States | 44111 |
| 234 | Cleveland Clinic Foundation | Cleveland | Ohio | United States | 44195 |
| 235 | Ohio State University Comprehensive Cancer Center | Columbus | Ohio | United States | 43210 |
| 236 | The Mark H Zangmeister Center | Columbus | Ohio | United States | 43219 |
| 237 | Good Samaritan Hospital - Dayton | Dayton | Ohio | United States | 45406 |
| 238 | Miami Valley Hospital | Dayton | Ohio | United States | 45409 |
| 239 | Dayton Physician LLC-Miami Valley Hospital North | Dayton | Ohio | United States | 45415 |
| 240 | Miami Valley Hospital North | Dayton | Ohio | United States | 45415 |
| 241 | Armes Family Cancer Center | Findlay | Ohio | United States | 45840 |
| 242 | Blanchard Valley Hospital | Findlay | Ohio | United States | 45840 |
| 243 | Orion Cancer Care | Findlay | Ohio | United States | 45840 |
| 244 | Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | United States | 45005-1066 |
| 245 | Dayton Physicians LLC-Atrium | Franklin | Ohio | United States | 45005 |
| 246 | Dayton Physicians LLC-Wayne | Greenville | Ohio | United States | 45331 |
| 247 | Wayne Hospital | Greenville | Ohio | United States | 45331 |
| 248 | Greater Dayton Cancer Center | Kettering | Ohio | United States | 45409 |
| 249 | First Dayton Cancer Care | Kettering | Ohio | United States | 45420 |
| 250 | Kettering Medical Center | Kettering | Ohio | United States | 45429 |
| 251 | Cleveland Clinic Cancer Center Mansfield | Mansfield | Ohio | United States | 44906 |
| 252 | Hillcrest Hospital Cancer Center | Mayfield Heights | Ohio | United States | 44124 |
| 253 | UH Seidman Cancer Center at Lake Health Mentor Campus | Mentor | Ohio | United States | 44060 |
| 254 | UH Seidman Cancer Center at Southwest General Hospital | Middleburg Heights | Ohio | United States | 44130 |
| 255 | University Hospitals Parma Medical Center | Parma | Ohio | United States | 44129 |
| 256 | University Hospitals Portage Medical Center | Ravenna | Ohio | United States | 44266 |
| 257 | North Coast Cancer Care | Sandusky | Ohio | United States | 44870 |
| 258 | UH Seidman Cancer Center at Firelands Regional Medical Center | Sandusky | Ohio | United States | 44870 |
| 259 | Springfield Regional Cancer Center | Springfield | Ohio | United States | 45504 |
| 260 | Springfield Regional Medical Center | Springfield | Ohio | United States | 45505 |
| 261 | Cleveland Clinic Cancer Center Strongsville | Strongsville | Ohio | United States | 44136 |
| 262 | Dayton Physicians LLC-Upper Valley | Troy | Ohio | United States | 45373 |
| 263 | Upper Valley Medical Center | Troy | Ohio | United States | 45373 |
| 264 | University of Cincinnati Cancer Center-West Chester | West Chester | Ohio | United States | 45069 |
| 265 | UHHS-Westlake Medical Center | Westlake | Ohio | United States | 44145 |
| 266 | Cleveland Clinic Wooster Family Health and Surgery Center | Wooster | Ohio | United States | 44691 |
| 267 | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 268 | Cancer Treatment Centers of America | Tulsa | Oklahoma | United States | 74133 |
| 269 | Legacy Mount Hood Medical Center | Gresham | Oregon | United States | 97030 |
| 270 | Legacy Good Samaritan Hospital and Medical Center | Portland | Oregon | United States | 97210 |
| 271 | UPMC Altoona | Altoona | Pennsylvania | United States | 16601 |
| 272 | UPMC-Heritage Valley Health System Beaver | Beaver | Pennsylvania | United States | 15009 |
| 273 | Saint Luke's University Hospital-Bethlehem Campus | Bethlehem | Pennsylvania | United States | 18015 |
| 274 | Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania | United States | 19317 |
| 275 | Northeast Radiation Oncology Center | Dunmore | Pennsylvania | United States | 18512 |
| 276 | UPMC Cancer Center at UPMC Horizon | Farrell | Pennsylvania | United States | 16121 |
| 277 | UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania | United States | 15601 |
| 278 | UPMC Pinnacle Cancer Center/Community Osteopathic Campus | Harrisburg | Pennsylvania | United States | 17109 |
| 279 | Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | United States | 17033-0850 |
| 280 | UPMC-Johnstown/John P. Murtha Regional Cancer Center | Johnstown | Pennsylvania | United States | 15901 |
| 281 | UPMC Cancer Center at UPMC McKeesport | McKeesport | Pennsylvania | United States | 15132 |
| 282 | UPMC Cancer Center - Monroeville | Monroeville | Pennsylvania | United States | 15146 |
| 283 | UPMC-Coraopolis/Heritage Valley Radiation Oncology | Moon | Pennsylvania | United States | 15108 |
| 284 | Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | United States | 19107 |
| 285 | Fox Chase Cancer Center | Philadelphia | Pennsylvania | United States | 19111 |
| 286 | Jefferson Torresdale Hospital | Philadelphia | Pennsylvania | United States | 19114 |
| 287 | UPMC-Magee Womens Hospital | Pittsburgh | Pennsylvania | United States | 15213 |
| 288 | UPMC-Saint Margaret | Pittsburgh | Pennsylvania | United States | 15215 |
| 289 | UPMC-Shadyside Hospital | Pittsburgh | Pennsylvania | United States | 15232 |
| 290 | UPMC-Passavant Hospital | Pittsburgh | Pennsylvania | United States | 15237 |
| 291 | UPMC-Saint Clair Hospital Cancer Center | Pittsburgh | Pennsylvania | United States | 15243 |
| 292 | Guthrie Medical Group PC-Robert Packer Hospital | Sayre | Pennsylvania | United States | 18840 |
| 293 | UPMC Cancer Center at UPMC Northwest | Seneca | Pennsylvania | United States | 16346 |
| 294 | UPMC Uniontown Hospital Radiation Oncology | Uniontown | Pennsylvania | United States | 15401 |
| 295 | UPMC Washington Hospital Radiation Oncology | Washington | Pennsylvania | United States | 15301 |
| 296 | Reading Hospital | West Reading | Pennsylvania | United States | 19611 |
| 297 | Asplundh Cancer Pavilion | Willow Grove | Pennsylvania | United States | 19090 |
| 298 | Prisma Health Cancer Institute - Spartanburg | Boiling Springs | South Carolina | United States | 29316 |
| 299 | Prisma Health Cancer Institute - Faris | Greenville | South Carolina | United States | 29605 |
| 300 | Prisma Health Cancer Institute - Eastside | Greenville | South Carolina | United States | 29615 |
| 301 | Self Regional Healthcare | Greenwood | South Carolina | United States | 29646 |
| 302 | Prisma Health Cancer Institute - Greer | Greer | South Carolina | United States | 29650 |
| 303 | The Radiation Oncology Center-Hilton Head/Bluffton | Hilton Head Island | South Carolina | United States | 29926 |
| 304 | Prisma Health Cancer Institute - Seneca | Seneca | South Carolina | United States | 29672 |
| 305 | Rapid City Regional Hospital | Rapid City | South Dakota | United States | 57701 |
| 306 | The West Clinic - Wolf River | Germantown | Tennessee | United States | 38138 |
| 307 | Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | United States | 37232 |
| 308 | UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | United States | 75390 |
| 309 | Audie L Murphy VA Hospital | San Antonio | Texas | United States | 78229 |
| 310 | University of Texas Health Science Center at San Antonio | San Antonio | Texas | United States | 78229 |
| 311 | American Fork Hospital / Huntsman Intermountain Cancer Center | American Fork | Utah | United States | 84003 |
| 312 | Sandra L Maxwell Cancer Center | Cedar City | Utah | United States | 84720 |
| 313 | Farmington Health Center | Farmington | Utah | United States | 84025 |
| 314 | Logan Regional Hospital | Logan | Utah | United States | 84321 |
| 315 | Intermountain Medical Center | Murray | Utah | United States | 84107 |
| 316 | McKay-Dee Hospital Center | Ogden | Utah | United States | 84403 |
| 317 | Utah Valley Regional Medical Center | Provo | Utah | United States | 84604 |
| 318 | Riverton Hospital | Riverton | Utah | United States | 84065 |
| 319 | Dixie Medical Center Regional Cancer Center | Saint George | Utah | United States | 84770 |
| 320 | Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah | United States | 84106 |
| 321 | Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | United States | 84112 |
| 322 | LDS Hospital | Salt Lake City | Utah | United States | 84143 |
| 323 | Southwestern Vermont Medical Center | Bennington | Vermont | United States | 05201 |
| 324 | Central Vermont Medical Center/National Life Cancer Treatment | Berlin | Vermont | United States | 05602 |
| 325 | University of Vermont Medical Center | Burlington | Vermont | United States | 05401 |
| 326 | University of Vermont and State Agricultural College | Burlington | Vermont | United States | 05405 |
| 327 | Norris Cotton Cancer Center-North | Saint Johnsbury | Vermont | United States | 05819 |
| 328 | Naval Medical Center - Portsmouth | Portsmouth | Virginia | United States | 23708-2197 |
| 329 | Hunter Holmes McGuire Veterans Administration Medical Center | Richmond | Virginia | United States | 23249 |
| 330 | PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | United States | 98225 |
| 331 | Legacy Salmon Creek Hospital | Vancouver | Washington | United States | 98686 |
| 332 | Providence Saint Mary Regional Cancer Center | Walla Walla | Washington | United States | 99362 |
| 333 | West Virginia University Healthcare | Morgantown | West Virginia | United States | 26506 |
| 334 | Camden Clark Medical Center | Parkersburg | West Virginia | United States | 26101 |
| 335 | Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin | United States | 54701 |
| 336 | Aurora Cancer Care-Grafton | Grafton | Wisconsin | United States | 53024 |
| 337 | Aurora BayCare Medical Center | Green Bay | Wisconsin | United States | 54311 |
| 338 | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | United States | 53142 |
| 339 | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | United States | 54449 |
| 340 | Froedtert Menomonee Falls Hospital | Menomonee Falls | Wisconsin | United States | 53051 |
| 341 | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | United States | 53215 |
| 342 | Medical College of Wisconsin | Milwaukee | Wisconsin | United States | 53226 |
| 343 | Zablocki Veterans Administration Medical Center | Milwaukee | Wisconsin | United States | 53295 |
| 344 | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin | United States | 54548 |
| 345 | Cancer Center of Western Wisconsin | New Richmond | Wisconsin | United States | 54017 |
| 346 | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | United States | 54904 |
| 347 | Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | United States | 54868 |
| 348 | Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin | United States | 53081 |
| 349 | Marshfield Clinic Stevens Point Center | Stevens Point | Wisconsin | United States | 54482 |
| 350 | Aurora Medical Center in Summit | Summit | Wisconsin | United States | 53066 |
| 351 | Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin | United States | 54241 |
| 352 | Aurora West Allis Medical Center | West Allis | Wisconsin | United States | 53227 |
| 353 | Froedtert West Bend Hospital/Kraemer Cancer Center | West Bend | Wisconsin | United States | 53095 |
| 354 | Diagnostic and Treatment Center | Weston | Wisconsin | United States | 54476 |
| 355 | Marshfield Medical Center - Weston | Weston | Wisconsin | United States | 54476 |
| 356 | Tom Baker Cancer Centre | Calgary | Alberta | Canada | T2N 4N2 |
| 357 | University Health Network-Princess Margaret Hospital | Toronto | Ontario | Canada | M5G 2M9 |
| 358 | CIUSSSEMTL-Hopital Maisonneuve-Rosemont | Montreal | Quebec | Canada | H1T 2M4 |
| 359 | The Research Institute of the McGill University Health Centre (MUHC) | Montreal | Quebec | Canada | H3H 2R9 |
| 360 | CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ) | Quebec City | Quebec | Canada | G1R 2J6 |
| 361 | Centre Hospitalier Universitaire de Sherbrooke-Fleurimont | Sherbrooke | Quebec | Canada | J1H 5N4 |
| 362 | Allan Blair Cancer Centre | Regina | Saskatchewan | Canada | S4T 7T1 |
| 363 | Saskatoon Cancer Centre | Saskatoon | Saskatchewan | Canada | S7N 4H4 |
Sponsors and Collaborators
- NRG Oncology
- National Cancer Institute (NCI)
Investigators
- Principal Investigator: Daniel Spratt, MD, NRG Oncology
- Principal Investigator: Felix Feng, MD, NRG Oncology
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NRG-GU006
- NCI-2017-01268
- NRG-GU006
- NRG-GU006
- U10CA180868