Psychiatric Comorbidity and Quality of Life in Patients With Obsessive Compulsive Disorder(Case Control Study )

Sponsor
Assiut University (Other)
Overall Status
Not yet recruiting
CT.gov ID
NCT05105581
Collaborator
(none)
37
5.9

Study Details

Study Description

Brief Summary

Psychiatric Comorbidity and quality of life in patients with Obsessive Compulsive Disorder(case control study )

Condition or Disease Intervention/Treatment Phase
  • Behavioral: Quality of life scale

Detailed Description

Obsessive-compulsive disorder (OCD) is a mental and behavioral disorder[7] in which a person has certain thoughts repeatedly (called "obsessions") and/or feels the need to perform certain routines repeatedly (called "compulsions") to an extent that generates distress or impairs general functioning.[1][2] The person is unable to control either the thoughts or activities for more than a short period of time.[1] Common compulsions include excessive hand washing, the counting of things, and checking to see if a door is locked.[1] These activities occur to such a degree that the person's daily life is negatively affected,[1] often taking up more than an hour a day.[2] Most adults realize that the behaviors do not make sense.[1] The condition is associated with tics, anxiety disorder, and an increased risk of suicide.[2][3] The cause is unknown.[1] There appear to be some genetic components, with both identical twins more often affected than both non-identical twins.[2] Risk factors include a history of child abuse or other stress-inducing event.[2] Some cases have been documented to occur following infections.[2] The diagnosis is based on the symptoms and requires ruling out other drug-related or medical causes.[2] Rating scales such as the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) can be used to assess the severity.[8] Other disorders with similar symptoms include anxiety disorder, major depressive disorder, eating disorders, tic disorders, and obsessive-compulsive personality disorder.[2]

Treatment may involve psychotherapy, such as cognitive behavioral therapy (CBT), and antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) or clomipramine.[4][5] CBT for OCD involves increasing exposure to fears and obsessions while preventing the compulsive behavior that would normally accompany the obsessions.[4] Contrary to this, metacognitive therapy encourages the ritual behaviors in order to alter the relationship to one's thoughts about them.[9] While clomipramine appears to work as well as do SSRIs, it has greater side effects and thus is typically reserved as a second-line treatment.[4] Atypical antipsychotics may be useful when used in addition to an SSRI in treatment-resistant cases but are also associated with an increased risk of side effects.[5][10] Without treatment, the condition often lasts decades.[2]

Study Design

Study Type:
Observational
Anticipated Enrollment :
37 participants
Observational Model:
Case-Control
Time Perspective:
Prospective
Official Title:
Psychiatric Comorbidity and Quality of Life in Patients With Obsessive Compulsive Disorder(Case Control Study )
Anticipated Study Start Date :
Nov 1, 2021
Anticipated Primary Completion Date :
Dec 1, 2021
Anticipated Study Completion Date :
May 1, 2022

Arms and Interventions

Arm Intervention/Treatment
Group 1 (Patients)

Patients: 37 patients with OCD diagnosed according to DSM-5 Inclusion criteria: both sex age groups : 18 : 60 are included accept to participate in the study Exclusion criteria presence of major neurological disease as head trauma and sensory or motor defect as blindness or deafness Active psychiatric disordes patients refuse to participate in the study

Group 2 (Controlled)

37 healthy populations matched with PT group in age , sex , socioeconomic state

Behavioral: Quality of life scale
To assess the quality of life of patient To assess the degree of OCD
Other Names:
  • Yale-Brown Obsessive-Compulsive Scale
  • Outcome Measures

    Primary Outcome Measures

    1. quality of life scale [about 6 months]

      assess the quality of life in OCD patients

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 60 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
      1. both sex 2. age groups : 18 : 60 are included 3. accept to participate in the study
    Exclusion Criteria:
      1. presence of major neurological disease as head trauma and sensory or motor defect as blindness or deafness
    1. Active psychiatric disordes 3. patients refuse to participate in the study

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • Assiut University

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Mohamed Safwat AbdElrhman, Assistant Professor of Psychiatry, Assiut University
    ClinicalTrials.gov Identifier:
    NCT05105581
    Other Study ID Numbers:
    • Assiut Unirvesity Hospital
    First Posted:
    Nov 3, 2021
    Last Update Posted:
    Nov 3, 2021
    Last Verified:
    Oct 1, 2021
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of Nov 3, 2021