The Social Regulation of Threat-related Vigilance and Arousal

Sponsor
University of Nevada, Reno (Other)
Overall Status
Not yet recruiting
CT.gov ID
NCT05558527
Collaborator
(none)
45
1
3
24
1.9

Study Details

Study Description

Brief Summary

This study will examine the effects of social support on threat vigilance and arousal using eye tracking. We will also test the moderating effects of trauma and discrimination history.

Condition or Disease Intervention/Treatment Phase
  • Behavioral: social support
N/A

Detailed Description

Both interpersonal trauma (IPT) and ethno-racial discrimination amplify risk for hyper-arousal symptoms of posttraumatic stress disorder (PTSD), but the mechanism of this effect is unclear. Prior research suggests that social support plays an important role in regulating emotional responses, a process called social emotion regulation. This study will test whether a history of IPT and/or ethno-racial discrimination influence the social regulation of arousal and vigilance. Social regulation will be tested by contrasting responses under conditions with and without social support.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
45 participants
Allocation:
Randomized
Intervention Model:
Crossover Assignment
Masking:
None (Open Label)
Primary Purpose:
Basic Science
Official Title:
Effects of Trauma and Discrimination on the Social Regulation of Threat-related Vigilance and Arousal
Anticipated Study Start Date :
Oct 1, 2022
Anticipated Primary Completion Date :
Oct 1, 2024
Anticipated Study Completion Date :
Oct 1, 2024

Arms and Interventions

Arm Intervention/Treatment
Experimental: Social support from a romantic partner

Participants will hold the hand of their romantic partner

Behavioral: social support
social support is provided in the form of social touch (hand holding)

Active Comparator: Social support from a stranger

Participants will hold the hand of a stranger

Behavioral: social support
social support is provided in the form of social touch (hand holding)

No Intervention: No social support

Participants will hold a stress ball

Outcome Measures

Primary Outcome Measures

  1. Vigilance Related Eye Movements - Number of Eye Fixations [Collected from minute 15 to minute 45 of study participation, approximately]

    Participants will view 15 pictures of natural environmental scenes for 10 seconds per image. We will use an eye tracker to examine the number of eye fixations per scene. A greater number of fixations during the 10 second presentation of a scene would indicate greater vigilance.

  2. Vigilance Related Eye Movements - Visual Scanning [Collected from minute 15 to minute 45 of study participation, approximately]

    Participants will view 15 pictures of natural environmental scenes for 10 seconds per image. We will use an eye tracker to examine the proportion of the scene that they look at (fixate on) out of approximately 80 possible sectors. A greater proportion of the scene they fixate on would indicate greater vigilance.

  3. Threat-Related Physiological Arousal - Pupil Dilation [Collected from minute 45 to minute 75 of study participation, approximately]

    Participants will view a series of visual cues (either an 'X' or an 'O') where an 'X' signals a possible (20% probability) aversive auditory stimulus (human scream). We will examine pupil dilation during the task in order to measure arousal in response to uncertain threat. We will calculate average pupil dilation during the wait period after threat cues (X) and after safety cues (O). We will subtract average pupil dilation after safety cues from threat cues to create an index of threat-related arousal. Greater pupil dilation (for threat minus safety cues) would indicate greater threat-related arousal.

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 65 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • In a stable romantic relationship for 6 months or more

  • Normal vision or corrected-to-normal vision

  • Fluent in English

Exclusion Criteria:
  • If vision is corrected-to-normal, needs to use hard contact lenses, bifocal contact lenses, or glasses

  • Experienced a traumatic event within the past 4 weeks

Contacts and Locations

Locations

Site City State Country Postal Code
1 University of Nevada, Reno Reno Nevada United States 89557

Sponsors and Collaborators

  • University of Nevada, Reno

Investigators

  • Principal Investigator: Cynthia L Lancaster, PhD, University of Nevada, Reno

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
University of Nevada, Reno
ClinicalTrials.gov Identifier:
NCT05558527
Other Study ID Numbers:
  • 1883993-2
First Posted:
Sep 28, 2022
Last Update Posted:
Sep 28, 2022
Last Verified:
Sep 1, 2022
Individual Participant Data (IPD) Sharing Statement:
Yes
Plan to Share IPD:
Yes
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by University of Nevada, Reno
Additional relevant MeSH terms:

Study Results

No Results Posted as of Sep 28, 2022