Pulmonary Infections Masquerading as Community-Acquired Pneumonia

Sponsor
Michael E. DeBakey VA Medical Center (U.S. Fed)
Overall Status
Completed
CT.gov ID
NCT00304395
Collaborator
Baylor College of Medicine (Other)
40
1
36
1.1

Study Details

Study Description

Brief Summary

The purpose of this research is to identify cases from patients who have been referred for consultation to the Infectious Disease Section at the VAMC, Houston, and to compare them with other cases of CAP in order to determine whether there are features that might enable non-CAP cases to be distinguished from CAP.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Guidelines to treat community acquired pneumonia (CAP) have been developed and widely promulgated by important professional societies in the past 10 years. The impetus to do so came from the observation that practicing physicians were using a wide array of approaches to this common infection, many of which were substandard.

    The Infectious Disease Society of America (IDSA) and American Thoracic Society (ATS) have been leaders in this field, publishing recommendations separately between 1993 and 2003. The PI served on the IDSA committee and coauthored the publication in 2000 and the update in 2003. In 2004, a decision was made by the two professional societies to merge the committees and make a single joint set of recommendations; the PI is a member of that joint committee and a new document is being prepared for publication.

    The PI has observed a tendency to apply these guidelines to cases that might masquerade as CAP but are actually attributable to other conditions, such as lung cancer, tuberculosis and histoplasmosis. Further, the recommendations do not adequately cover pneumonia due to Staphylococcus aureus.

    The purpose of the research is to identify cases from the consult records of the Infectious Disease Section at the VAMC, Houston, and to compare them with other cases of CAP in order to determine whether there are features that might enable non-CAP cases to be distinguished from CAP.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    40 participants
    Observational Model:
    Cohort
    Time Perspective:
    Retrospective
    Official Title:
    Pulmonary Infections Masquerading as Community-Acquired Pneumonia
    Study Start Date :
    Jan 1, 2004
    Actual Primary Completion Date :
    Jan 1, 2007
    Actual Study Completion Date :
    Jan 1, 2007

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years to 64 Years
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:
      • subjects who were seen in calendar year 2004 because they were thought to have CAP, but who, upon further evaluation, plainly did not, and consultation was sought.

      • case control is diagnosis of CAP with verification by all or nearly all of the following features: presence of cough, increased sputum, fever, leukocytosis and a distinct new pulmonary infiltrate.

      Exclusion Criteria:
      • among the case controls, if the diagnosis of CAP was made despite the absence of the cardinal features of CAP, as cited above, the investigators will not include the case.

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Michael E. DeBakey Veterans Affairs Medical Center Houston Texas United States 77030

      Sponsors and Collaborators

      • Michael E. DeBakey VA Medical Center
      • Baylor College of Medicine

      Investigators

      • Principal Investigator: Daniel M Musher, M.D., Baylor College of Medicine, Houston VA Medical Center

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      Daniel M. Musher MD, Principal Investigator, Michael E. DeBakey VA Medical Center
      ClinicalTrials.gov Identifier:
      NCT00304395
      Other Study ID Numbers:
      • H-17555
      First Posted:
      Mar 17, 2006
      Last Update Posted:
      Oct 29, 2021
      Last Verified:
      Oct 1, 2021
      Keywords provided by Daniel M. Musher MD, Principal Investigator, Michael E. DeBakey VA Medical Center
      Additional relevant MeSH terms:

      Study Results

      No Results Posted as of Oct 29, 2021