Quality of Life Among Egyptian Hypothyroid Patients
Study Details
Study Description
Brief Summary
Assessment of quality of life among hypothyroid patients in Assiut University Hospital
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Hypothyroidism is an underactive thyroid gland. Hypothyroidism means that the thyroid gland can't make enough thyroid hormone to keep the body running normally. People are hypothyroid if they have too little thyroid hormone in the blood. Common causes are Iodine deficiency, autoimmune disease, such as Hashimoto's thyroiditis, surgical removal of the thyroid, and radiation treatment.
There are three types of hypothyroidism: primary, secondary and tertiary. Primary hypothyroidism results from a low level of thyroid hormone due to destruction of the thyroid gland. This condition results in increased secretion and elevation of serum thyroid-stimulating hormone (TSH) levels. If the structure of the gland remains normal, dysfunction can be caused by decreased TSH secretion from the pituitary; this Is called secondary hypothyroidism.
In tertiary hypothyroidism, a decrease in thyroid hormone arises from inadequate secretion of thyrotropin-releasing hormone (TRH) from the hypothalamus. It is not always possible to differentiate between secondary and tertiary hypothyroidism, and they are often collectively referred to as central hypothyroidism. About 99%ofhypothyroidism cases are primary hypothyroidism.
Hypothyroidism is common throughout the world. In iodine-sufficient countries, the prevalence of hypothyroidism ranges from 1% to 2%. rising to 7% in individuals aged between 85 and 89 years. In the absence of age-specific reference ranges for TSH, an ageing population is likely to result in a higher prevalence of hypothyroidism. Hypothyroidism is approximately ten times more prevalent in women than men10. the awareness of hypothyroidism has increased gradually, as has rate of initiation of levothyroxine substitution.
Symptoms usually develop slowly and the patient may not realise to have a medical problem for several years. Common symptoms include: tiredness, being sensitive to cold, weight gain, constipation, depression, slow movements and thoughts, muscle aches and weakness, muscle cramps, dry and scaly skin, brittle hair and nails, loss of libido (sex drive), pain, numbness and a tingling sensation in the hand and fingers (carpal tunnel syndrome),irregular periods or heavy periods.
Health-related quality of life (HRQL) is a subjective assessment of the effects of disease and its treatment on the physical, social, psychological, and somatic dimensions of a patient's life. Thus, HRQL is considered an important supplementary outcome measure in the management of different conditions.
Thyroid hormones are important for the body's total energy metabolism and the neuroendocrine function. Hence, it seems apparent that a dysfunction of the thyroid hormone secretion should have a major influence on the total capacity of the body, both physically and mentally. Increasing attention is being paid to assessing HRQL among patients with thyroid disorders, and previous studies have revealed that HRQL is frequently affected in patients with hypothyroidism.
Up to our knowledge, no previous study explored the quality of life and its correlates among Egyptian hypothyroidism patients. The current study aims to assess the quality of life and its predictor among hypothyroidism in Assiut University Hospital
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Hypothyroid patients as a cases Inclusion criteria: age ranges will be 18 - 60 years both genders previously confirmed diagnosed Exclusion criteria: pregnancy other comorbidities (hypertension, diabetes, malignancy,,,etc) |
Other: assessment of quality of life using questionnaire
assessment of quality of life in hypothyroid patients using SF 36 questionnaire
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Control group Healthy people without chronic disease |
Other: assessment of quality of life using questionnaire
assessment of quality of life in hypothyroid patients using SF 36 questionnaire
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Outcome Measures
Primary Outcome Measures
- predictors of quality of life among hypothyroid patients [nearly two year]
Using the Short Form (36) Health Survey (SF-36) questionnaire all items are scored so that a high score defines a more favorable health state. In addition, each item is scored on a 0 to 100 range so that the lowest and highest possible scores are 0 and 100.
Eligibility Criteria
Criteria
Inclusion Criteria:
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age ranges will be 18 - 60 years
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both genders
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previously confirmed diagnosed
Exclusion Criteria:
- Exclusion criteria:
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pregnancy
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other comorbidities (hypertension, diabetes, malignancy,,,etc)
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Assiut University
Investigators
- Study Chair: Nabawia M Tawfik, Assiut University
- Study Director: Ghada Abd El Rahman, Assiut University
- Study Director: Doaa M Osman, Assiut University
- Principal Investigator: Noha F Radwan, Assiut University
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
- Błażewicz A, Wiśniewska P, Skórzyńska-Dziduszko K. Selected Essential and Toxic Chemical Elements in Hypothyroidism-A Literature Review (2001-2021). Int J Mol Sci. 2021 Sep 20;22(18). pii: 10147. doi: 10.3390/ijms221810147. Review.
- Shivaprasad C, Rakesh B, Anish K, Annie P, Amit G, Dwarakanath CS. Impairment of Health-related Quality of Life among Indian Patients with Hypothyroidism. Indian J Endocrinol Metab. 2018 May-Jun;22(3):335-338. doi: 10.4103/ijem.IJEM_702_17.
- Taylor PN, Albrecht D, Scholz A, Gutierrez-Buey G, Lazarus JH, Dayan CM, Okosieme OE. Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol. 2018 May;14(5):301-316. doi: 10.1038/nrendo.2018.18. Epub 2018 Mar 23. Review.
- quality of life