Rebound Pain Following Surgery With Regional Anesthesia Block

University of Alberta (Other)
Overall Status
Not yet recruiting ID

Study Details

Study Description

Brief Summary

For some kinds of surgery, Anesthesiologists provide nerve blocks (regional anesthesia) to reduce pain from surgery by injecting freezing medication around deep nerves with ultrasound. Nerve blocks help with pain control following surgery and reduce the amount of strong opioids needed but relatively little research has focused on the pain that occurs once the nerve block has worn off. This is called rebound or transition pain.

This research study will prospectively collect data including pain scores before, during and after nerve blocks are given for surgery. We will look at the type of nerve blocks and other analgesia medications used with the aim of quantifying rebound pain to better understand how to limit it's impact on quality postoperative pain control.

Condition or Disease Intervention/Treatment Phase
  • Other: Numerical Pain Scales

Study Design

Study Type:
Anticipated Enrollment :
500 participants
Observational Model:
Time Perspective:
Official Title:
Rebound Pain Following Surgery With Regional Anesthesia Block: A Prospective Cohort Study
Anticipated Study Start Date :
Aug 1, 2022
Anticipated Primary Completion Date :
Dec 31, 2023
Anticipated Study Completion Date :
Dec 31, 2023

Arms and Interventions

Arm Intervention/Treatment
Regional Nerve Block Patients

Patients who receive regional nerve blocks as part of the anesthetic management prior to surgery.

Other: Numerical Pain Scales
Patients who are about to receive regional nerve blocks will be administered a numerical pain scale (NRS) before, during and after the offset of the nerve block.

Outcome Measures

Primary Outcome Measures

  1. Numerical Pain Scale [2-3 times per patient over the course of a nerve block, up to 48 hours after the stop of the block (single shot or cessation of nerve catheter)]

Eligibility Criteria


Ages Eligible for Study:
18 Years to 75 Years
Sexes Eligible for Study:
Inclusion Criteria:
  • Age 18-75 years

  • Receiving peripheral nerve block as part for anesthesia/analgesia as part of standard perioperative care for surgery performed at University of Alberta Hospital during a 6 month period

  • Elective and emergency surgery

Exclusion Criteria:
  • Inability to consent to participate in the study (illiteracy, <7th grade education)

  • Contraindication/history of hypersensitivity to local anesthetics

Contacts and Locations


No locations specified.

Sponsors and Collaborators

  • University of Alberta


  • Principal Investigator: James Green, MD, University of Alberta Department of Anesthesiology and Pain Medicine

Study Documents (Full-Text)

None provided.

More Information


Responsible Party:
University of Alberta Identifier:
Other Study ID Numbers:
  • ReboundPain
First Posted:
May 2, 2022
Last Update Posted:
Jul 27, 2022
Last Verified:
Apr 1, 2022
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD:
Studies a U.S. FDA-regulated Drug Product:
Studies a U.S. FDA-regulated Device Product:
Keywords provided by University of Alberta
Additional relevant MeSH terms:

Study Results

No Results Posted as of Jul 27, 2022