Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer
Study Details
Study Description
Brief Summary
This randomized phase II trial studies how well veliparib or pembrolizumab work with combination chemotherapy and radiation therapy in treating patients with rectal cancer that has spread from where it started to nearby tissue or lymph nodes (locally advanced). Veliparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as modified (m)FOLFOX6 regimen, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Giving veliparib or pembrolizumab with combination chemotherapy and radiation therapy may kill more tumor cells, make the tumor smaller, and reduce the amount of normal tissue that needs to be removed.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 2 |
Detailed Description
PRIMARY OBJECTIVE:
- To demonstrate an absolute improvement in neoadjuvant rectal cancer (NAR) score for the experimental regimen as compared to concurrently randomized control patients.
SECONDARY OBJECTIVES:
-
To compare overall survival (OS). II. To compare disease-free survival (DFS). III. To compare the rate of pathologic complete response (pCR) (nodes and tumor).
-
To compare the rate of sphincter preservation.
TERTIARY OBJECTIVES:
-
To compare the proportion of patients who have a tumor resection overall, conditional on beginning induction chemotherapy, and conditional on beginning chemoradiotherapy.
-
To compare time from initiation of chemoradiotherapy to surgery in the subset of patients with tumor resection.
EXPLORATORY OBJECTIVES:
-
To estimate the rate of disease progression during chemotherapy (prior to chemoradiation).
-
To compare the rate of clinical complete response rate (cCR). III. To compare the rate of negative circumferential margin. IV. To compare the rate of completion of all cycles of neoadjuvant chemotherapy.
-
To compare the rate of completion of full course of chemoradiation. VI. To compare the toxicity and safety between interventions. VII. To explore the correlative molecular predictors of response and distant failure.
-
To explore the relationship between radiographic findings and pathologic outcomes.
OUTLINE: Patients are randomized to 1 of 3 treatment arms.
ARM I: Patients receive mFOLFOX6 regimen consisting of oxaliplatin intravenously (IV) over 2 hours, leucovorin calcium IV over 2 hours on day 1, and fluorouracil IV continuously over 46-48 hours on days 1-2. Treatment repeats every 2 weeks for 8 cycles in the absence of disease progression or unacceptable toxicity. 3-4 weeks after last does of mFOLFOX6 patient undergo radiation therapy (RT) and receive capecitabine orally (PO) twice daily (BID) Monday-Friday for 5 weeks in the absence of disease progression or unacceptable toxicity.
ARM II: Patients receive mFOLFOX6 regimen consisting of oxaliplatin IV over 2 hours, leucovorin calcium IV over 2 hours on day 1, and fluorouracil IV continuously over 46-48 hours on days 1-2. Treatment repeats every 2 weeks for 8 cycles in the absence of disease progression or unacceptable toxicity. 3-4 weeks after last does of mFOLFOX6 patient undergo RT and receive capecitabine PO BID and veliparib PO BID Monday-Friday for 5 weeks in the absence of disease progression or unacceptable toxicity.
ARM III: Patients receive mFOLFOX6 regimen consisting of oxaliplatin IV over 2 hours, leucovorin calcium IV over 2 hours on day 1, and fluorouracil IV continuously over 46-48 hours on days 1-2. Treatment repeats every 2 weeks for 8 cycles in the absence of disease progression or unacceptable toxicity. 3-4 weeks after last does of mFOLFOX6 patient undergo RT and receive capecitabine PO BID Monday-Friday for 5 weeks. They also receive pembrolizumab IV over 30 minutes every 3 weeks beginning on day 1 of RT for up to 6 cycles in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up at 30 days and every 6 months for up to 3 years.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: Arm I (mFOLFOX6, RT, capecitabine) Patients receive mFOLFOX6 regimen consisting of oxaliplatin IV over 2 hours on day 1, leucovorin calcium IV over 2 hours on day 1, and fluorouracil IV continuously over 46-48 hours on days 1-2. Treatment repeats every 2 weeks for 8 cycles in the absence of disease progression or unacceptable toxicity. 3-4 weeks after last does of mFOLFOX6 patient undergo RT and receive capecitabine PO BID Monday-Friday for 5 weeks in the absence of disease progression or unacceptable toxicity. |
Drug: Capecitabine
Given PO
Other Names:
Drug: Fluorouracil
Given IV
Other Names:
Radiation: Intensity-Modulated Radiation Therapy
Undergo intensity modulated radiation therapy
Other Names:
Drug: Leucovorin
Given IV
Other Names:
Drug: Oxaliplatin
Given IV
Other Names:
|
| Experimental: Arm II (mFOLFOX6, RT, capecitabine, veliparib) Patients receive mFOLFOX6 regimen consisting of oxaliplatin IV over 2 hours on day 1, leucovorin calcium IV over 2 hours on day 1, and fluorouracil IV continuously over 46-48 hours on days 1-2. Treatment repeats every 2 weeks for up to 8 cycles in the absence of disease progression or unacceptable toxicity. 3-4 weeks after last does of mFOLFOX6 patient undergo RT and receive capecitabine PO BID and veliparib PO BID Monday-Friday for 5 weeks in the absence of disease progression or unacceptable toxicity. |
Drug: Capecitabine
Given PO
Other Names:
Drug: Fluorouracil
Given IV
Other Names:
Radiation: Intensity-Modulated Radiation Therapy
Undergo intensity modulated radiation therapy
Other Names:
Drug: Leucovorin
Given IV
Other Names:
Drug: Oxaliplatin
Given IV
Other Names:
Drug: Veliparib
Given PO
Other Names:
|
| Experimental: Arm III (mFOLFOX6, RT, capecitabine, pembrolizumab) ARM III: Patients receive mFOLFOX6 regimen consisting of oxaliplatin IV over 2 hours, leucovorin calcium IV over 2 hours on day 1, and fluorouracil IV continuously over 46-48 hours on days 1-2. Treatment repeats every 2 weeks for 8 cycles in the absence of disease progression or unacceptable toxicity. 3-4 weeks after last does of mFOLFOX6 patient undergo RT and receive capecitabine PO BID Monday-Friday for 5 weeks. They also receive pembrolizumab IV over 30 minutes every 3 weeks beginning on day 1 of RT for up to 6 cycles in the absence of disease progression or unacceptable toxicity. |
Drug: Capecitabine
Given PO
Other Names:
Drug: Fluorouracil
Given IV
Other Names:
Radiation: Intensity-Modulated Radiation Therapy
Undergo intensity modulated radiation therapy
Other Names:
Drug: Leucovorin
Given IV
Other Names:
Drug: Oxaliplatin
Given IV
Other Names:
Biological: Pembrolizumab
Given IV
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Change in neoadjuvant rectal cancer (NAR) score [Baseline to up to 3 years]
A linear regression model that controls for the stratification factors (cT-stage and cN-stage) will be used. Mean NAR scores along with standard errors and confidence intervals will be reported by treatment.
Secondary Outcome Measures
- Overall survival [Time from start of study treatment, assessed up to 3 years]
Analyzed using the stratified log rank test with strata cT-stage and cN-stage. Kaplan-Meier plots will illustrate the distribution of these endpoints by treatment. Cox regression models will be used to estimate hazard ratios and associated confidence intervals.
- Disease free survival [Time from start of study treatment, assessed up to 3 years]
Analyzed using the stratified log rank test with strata cT-stage and cN-stage. Kaplan-Meier plots will illustrate the distribution of these endpoints by treatment. Cox regression models will be used to estimate hazard ratios and associated confidence intervals.
- Rate of pathologic complete response (nodes and tumor) ypT0 and ypN0 [Up to 3 years]
Analyzed by a logistic regression model that controls for the stratification factors (cT-stage and cN-stage). Observed proportions along with confidence intervals will be presented by treatment.
- Rate of sphincter preservation [Up to 3 years]
Analyzed by a logistic regression model that controls for the stratification factors (cT-stage and cN-stage). Observed proportions along with confidence intervals will be presented by treatment.
Other Outcome Measures
- Proportion of patients who have a tumor resection overall (and conditional on beginning induction chemotherapy, and conditional on beginning chemoradiotherapy) [Up to 3 years]
Analyzed by a logistic regression model that controls for the stratification factors (cT-stage and cN-stage). Observed proportions along with confidence intervals will be presented by treatment.
- Time from initiation of chemoradiotherapy to surgery in the subset of patients with tumor resection [Up to 3 years]
Analyzed using the stratified log rank test with strata cT-stage and cN-stage. Kaplan-Meier plots will illustrate the distribution of time to surgery (TTS) by treatment. Cox regression models will be used to estimate hazard ratios and associated confidence intervals.
- Rate of disease progression during chemotherapy (prior to chemoradiation) [Up to 3 years]
Analyzed by a logistic regression model that controls for the stratification factors (cT-stage and cN-stage). Observed proportions along with confidence intervals will be presented by treatment.
- Rate of clinical complete response rate, ycT0 [Up to 3 years]
Analyzed by a logistic regression model that controls for the stratification factors (cT-stage and cN-stage). Observed proportions along with confidence intervals will be presented by treatment.
- Rate of negative circumferential margin [Up to 3 years]
Analyzed by a logistic regression model that controls for the stratification factors (cT-stage and cN-stage). Observed proportions along with confidence intervals will be presented by treatment.
- Rate of completion of all cycles of neoadjuvant chemotherapy [Up to 3 years]
Analyzed by a logistic regression model that controls for the stratification factors (cT-stage and cN-stage). Observed proportions along with confidence intervals will be presented by treatment.
- Rate of completion of full course of chemoradiation [Up to 3 years]
Analyzed by a logistic regression model that controls for the stratification factors (cT-stage and cN-stage). Observed proportions along with confidence intervals will be presented by treatment.
- Incidence of toxicity including patient-reported toxicities [30 days after last study treatment]
Will be assessed using Common Terminology for Adverse Events (CTCAE) version 4.0 (CTCAE version 5.0 beginning April 1, 2018).
- Correlative molecular predictors of response and distant failure [Up to 3 years]
Cox regression models will be used to evaluate markers for time-to-event variables. Logistic regression models will be used for binary variables. Models will control for stratification factors and possibly other prognostic variables (e.g. gender or treatment).
- Relationship between radiographic findings and pathologic outcomes [Up to 3 years]
Will explore the relationship between radiographic findings and pathologic outcomes.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines
-
Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2
-
Diagnosis of adenocarcinoma of the rectum with the major portion of the tumor intact; Note: prior to randomization, the investigator must specify and document each of the following:
-
Distance of the lowest tumor margin from the anal verge; and
-
Intent for sphincter sparing or non-sphincter sparing surgical resection according to the primary surgeon; and
-
The majority of the untreated tumor must be < 12 cm from the anal verge or below the peritoneal reflection as determined by the treating surgeon
-
The tumor must be clinically determined to be locally advanced stage II or stage III rectal cancer, and must also meet any ONE of the following criteria:
-
Distal location (as defined by measurement on magnetic resonance imaging [MRI], transrectal ultrasound [ERUS]/pelvic computed tomography [CT] [with IV contrast] scan or palpable on digital rectal examination [DRE]): cT3-4 =< 5 cm from the anal verge, any N
-
Bulky: any cT4 or evidence that the tumor is adjacent to (defined as within 3 mm of) the mesorectal fascia on MRI or ERUS/pelvic CT (with IV contrast) scan
-
High risk for metastatic disease with 4 or more regional lymph nodes (cN2); clinical nodal or "cN" status for eligibility includes the total number of nodes (N2 = 4 or more) in the mesorectal and superior rectal stations measuring >= 1.0 cm in any axis on cross sectional or endoscopic imaging; Note: nodes must measure 1.0 cm or greater to be considered positive for this eligibility requirement
-
Not a candidate for sphincter-sparing surgical resection prior to neoadjuvant therapy (as planned by the primary surgeon)
-
Note: clinical stage of the primary tumor and nodes may be determined locally by rectal endoscopic ultrasound or pelvic MRI (pelvic MRI is strongly preferred); CT scan with IV contrast is acceptable provided there is evidence of T4 and/or N2 disease
-
Patients must have the ability to swallow and retain oral medication
-
Absolute neutrophil count (ANC) must be >= 1200/mm^3 (within 28 days before randomization)
-
Platelet count must be >= 100,000/mm^3 (within 28 days before randomization)
-
Hemoglobin must be >= 10 g/dL (within 28 days before randomization)
-
Total bilirubin must be =< ULN (upper limit of normal) for the lab unless the patient has a bilirubin elevation > ULN to 1.5 x ULN due to Gilbert's disease or similar syndrome involving slow conjugation of bilirubin (within 28 days before randomization)
-
Alkaline phosphatase must be =< 3 x ULN for the lab (within 28 days before randomization)
-
Aspartate aminotransferase (AST) must be =< 3 x ULN for the lab (within 28 days before randomization);
-
Note: if alanine aminotransferase (ALT) is performed instead of AST (per institution's standard practice), the ALT value must be =< 3 x ULN; if both were performed, the AST must also be =< 3 x ULN; if AST and/or ALT is >= ULN but =< 3 x ULN, serologic testing for hepatitis B and C must be performed and results for viral infection must be negative
-
Serum creatinine =< ULN for the lab and measured or calculated creatinine clearance > 60 mL/min (within 28 days before randomization)
-
Serum potassium, magnesium, and calcium levels within 28 days before randomization must be within normal limits (WNL) for the lab
-
International normalized ratio of prothrombin time (INR) within 28 days before randomization must be =< ULN for the lab; patients who are therapeutically treated with an agent such as warfarin may participate if they are on a stable dose and no underlying abnormality in coagulation parameters exists per medical history
-
Patients with acquired immunodeficiency syndrome (AIDS-related illnesses) or known human immunodeficiency virus (HIV) disease must:
-
Have a cluster of differentiation (CD)4 count >= 200 cells/uL within 30 days before beginning study therapy
-
Be off all antiretroviral therapy (prophylaxis/treatment) more than 60 days before beginning study therapy, and
-
Have no evidence of opportunistic infections
-
Pregnancy test (urine or serum beta-human chorionic gonadotropin [HCG]) done within 72 hours before randomization must be negative (for women of childbearing potential only); if urine pregnancy results are positive or cannot be confirmed as negative, a serum pregnancy test will be required
Exclusion Criteria:
-
Rectal cancer histology other than adenocarcinoma (i.e., sarcoma, lymphoma, squamous cell carcinoma, mucosal melanoma, etc.)
-
Definitive clinical or radiologic evidence of metastatic disease; required imaging studies must have been performed within 28 days prior to randomization; Note: Distant clinical staging to exclude patients with overt metastatic disease is determined by:
-
Chest: CT scan (preferred); chest x-ray posterioranterior (PA) and lateral (acceptable); or positron emission tomography (PET) scan (acceptable)
-
Abdomen: CT scan with IV contrast (preferred); or MRI (acceptable)
-
Pelvis: MRI (preferred) or CT scan with IV contrast (acceptable)
-
(It is recommended that the same imaging tests that are performed before randomization be used at follow-up time points; Note: CT scans of the abdomen and pelvis must be performed with IV contrast)
-
History of prior invasive rectal malignancy, regardless of disease-free interval
-
Cardiac disease that would preclude the use of any of the drugs included in the GI002 treatment regimen; this includes but is not limited to:
-
Clinically unstable cardiac disease, including unstable atrial fibrillation, symptomatic bradycardia, unstable congestive heart failure, active myocardial ischemia, or indwelling temporary pacemaker
-
Ventricular tachycardia or supraventricular tachycardia that requires treatment with class Ia antiarrhythmic drugs (e.g., quinidine, procainamide, disopyramide) or class III antiarrhythmic drug (e.g., sotalol, amiodarone, dofetilide); use of other antiarrhythmic drugs is permitted
-
Second- or third-degree atrioventricular (AV) block unless treated with a permanent pacemaker
-
Complete left bundle branch block (LBBB)
-
History of long QT syndrome
-
Corrected QT (QTc) >= 450 ms
-
Sensory or motor neuropathy >= grade 2
-
History of, or any evidence of active, non-infectious pneumonitis
-
Active inflammatory bowel disease (i.e., patients requiring current medical interventions or who are symptomatic) or have a history of abdominal surgery or other medical condition that may, in the opinion of the treating physician, interfere with gastrointestinal motility or absorption
-
Active autoimmune disease that has required systemic treatment within the past 2 years (i.e., with use of modifying agents, corticosteroids, or immunosuppressive drugs); replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment
-
History of active TB (Bacillus tuberculosis)
-
Active or chronic infection requiring systemic therapy
-
Diagnosis of immunodeficiency or receiving systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of study therapy; the use of physiologic doses of corticosteroids may be approved after consultation with the study principal investigator (PI)
-
Active seizure disorder uncontrolled by medication
-
Any antineoplastic therapy for this cancer before randomization
-
Synchronous colon cancer
-
Other invasive cancer within 5 years before randomization; exceptions are colonic polyps, non-melanoma skin cancer or carcinoma-in-situ of the cervix
-
Antineoplastic therapy (e.g. chemotherapy or targeted therapy) for other invasive cancer within 5 years before randomization; (for the purposes of this study, hormonal therapy is not considered chemotherapy)
-
Prior treatment with an investigational compound being tested in this study (e.g., poly ADP ribose polymerase [PARP] inhibitor, anti-PD-1, anti-PD-L1, or anti-PD-L2)
-
Receipt of live vaccination within 28 days before randomization; seasonal flu vaccines that do not contain live virus are permitted
-
Major surgery within 4 weeks before randomization
-
Any therapeutic pelvic radiation
-
Known homozygous DPD (dihydro pyrimidine dehydrogenase) deficiency
-
Any of the following because this study involves agents that have known or potential genotoxic or mutagenic, and teratogenic effects:
-
Pregnant women
-
Nursing women who are unwilling to discontinue nursing
-
Men or women of childbearing potential who are unwilling to employ adequate contraception (e.g., hormonal or barrier method of birth control; abstinence) for the duration of study treatment and for 4 months after the last dose of study therapy
-
Co-morbid illnesses or other concurrent disease that, in the judgement of the clinician obtaining informed consent, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens or prevent required follow-up
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | United States | 35233 |
| 2 | Southern Cancer Center PC-Mobile | Mobile | Alabama | United States | 36607 |
| 3 | Southern Cancer Center PC-Providence | Mobile | Alabama | United States | 36608 |
| 4 | Southern Cancer Center PC-Springhill | Mobile | Alabama | United States | 36608 |
| 5 | University of South Alabama Mitchell Cancer Institute | Mobile | Alabama | United States | 36688 |
| 6 | Fairbanks Memorial Hospital | Fairbanks | Alaska | United States | 99701 |
| 7 | Banner MD Anderson Cancer Center | Gilbert | Arizona | United States | 85234 |
| 8 | Mayo Clinic in Arizona | Scottsdale | Arizona | United States | 85259 |
| 9 | University of Arizona Cancer Center-Orange Grove Campus | Tucson | Arizona | United States | 85704 |
| 10 | Banner University Medical Center - Tucson | Tucson | Arizona | United States | 85719 |
| 11 | University of Arizona Cancer Center-North Campus | Tucson | Arizona | United States | 85719 |
| 12 | Mercy Hospital Fort Smith | Fort Smith | Arkansas | United States | 72903 |
| 13 | CHI Saint Vincent Cancer Center Hot Springs | Hot Springs | Arkansas | United States | 71913 |
| 14 | NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro | Arkansas | United States | 72401 |
| 15 | University of Arkansas for Medical Sciences | Little Rock | Arkansas | United States | 72205 |
| 16 | Kaiser Permanente-Anaheim | Anaheim | California | United States | 92806 |
| 17 | Kaiser Permanente-Deer Valley Medical Center | Antioch | California | United States | 94531 |
| 18 | PCR Oncology | Arroyo Grande | California | United States | 93420 |
| 19 | Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn | California | United States | 95603 |
| 20 | AIS Cancer Center at San Joaquin Community Hospital | Bakersfield | California | United States | 93301 |
| 21 | Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California | United States | 94704 |
| 22 | Mills-Peninsula Medical Center | Burlingame | California | United States | 94010 |
| 23 | Sutter Cancer Centers Radiation Oncology Services-Cameron Park | Cameron Park | California | United States | 95682 |
| 24 | Eden Hospital Medical Center | Castro Valley | California | United States | 94546 |
| 25 | Enloe Medical Center | Chico | California | United States | 95926 |
| 26 | City of Hope Corona | Corona | California | United States | 92879 |
| 27 | City of Hope Comprehensive Cancer Center | Duarte | California | United States | 91010 |
| 28 | Kaiser Permanente Dublin | Dublin | California | United States | 94568 |
| 29 | Kaiser Permanente-Fremont | Fremont | California | United States | 94538 |
| 30 | Fresno Cancer Center | Fresno | California | United States | 93720 |
| 31 | Kaiser Permanente-Fresno | Fresno | California | United States | 93720 |
| 32 | UC San Diego Moores Cancer Center | La Jolla | California | United States | 92093 |
| 33 | City of Hope Antelope Valley | Lancaster | California | United States | 93534 |
| 34 | Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | United States | 90027 |
| 35 | Los Angeles County-USC Medical Center | Los Angeles | California | United States | 90033 |
| 36 | USC / Norris Comprehensive Cancer Center | Los Angeles | California | United States | 90033 |
| 37 | Cedars Sinai Medical Center | Los Angeles | California | United States | 90048 |
| 38 | Fremont - Rideout Cancer Center | Marysville | California | United States | 95901 |
| 39 | Memorial Medical Center | Modesto | California | United States | 95355 |
| 40 | Kaiser Permanente-Modesto | Modesto | California | United States | 95356 |
| 41 | Palo Alto Medical Foundation-Camino Division | Mountain View | California | United States | 94040 |
| 42 | Sutter Cancer Research Consortium | Novato | California | United States | 94945 |
| 43 | Kaiser Permanente Oakland-Broadway | Oakland | California | United States | 94611 |
| 44 | Kaiser Permanente-Oakland | Oakland | California | United States | 94611 |
| 45 | UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | United States | 92868 |
| 46 | Palo Alto Medical Foundation Health Care | Palo Alto | California | United States | 94301 |
| 47 | Kaiser Permanente-Rancho Cordova Cancer Center | Rancho Cordova | California | United States | 95670 |
| 48 | Kaiser Permanente-Redwood City | Redwood City | California | United States | 94063 |
| 49 | Kaiser Permanente-Richmond | Richmond | California | United States | 94801 |
| 50 | Kaiser Permanente-Riverside | Riverside | California | United States | 92505 |
| 51 | Rohnert Park Cancer Center | Rohnert Park | California | United States | 94928 |
| 52 | Kaiser Permanente-Roseville | Roseville | California | United States | 95661 |
| 53 | Sutter Cancer Centers Radiation Oncology Services-Roseville | Roseville | California | United States | 95661 |
| 54 | Sutter Roseville Medical Center | Roseville | California | United States | 95661 |
| 55 | The Permanente Medical Group-Roseville Radiation Oncology | Roseville | California | United States | 95678 |
| 56 | Kaiser Permanente Downtown Commons | Sacramento | California | United States | 95814 |
| 57 | Sutter Medical Center Sacramento | Sacramento | California | United States | 95816 |
| 58 | University of California Davis Comprehensive Cancer Center | Sacramento | California | United States | 95817 |
| 59 | Kaiser Permanente-South Sacramento | Sacramento | California | United States | 95823 |
| 60 | South Sacramento Cancer Center | Sacramento | California | United States | 95823 |
| 61 | Kaiser Permanente - Sacramento | Sacramento | California | United States | 95825 |
| 62 | Kaiser Permanente-San Diego Zion | San Diego | California | United States | 92120 |
| 63 | California Pacific Medical Center-Pacific Campus | San Francisco | California | United States | 94115 |
| 64 | Kaiser Permanente-San Francisco | San Francisco | California | United States | 94115 |
| 65 | Kaiser Permanente-Santa Teresa-San Jose | San Jose | California | United States | 95119 |
| 66 | Kaiser Permanente San Leandro | San Leandro | California | United States | 94577 |
| 67 | Kaiser Permanente-San Marcos | San Marcos | California | United States | 92078 |
| 68 | Kaiser Permanente-San Rafael | San Rafael | California | United States | 94903 |
| 69 | Kaiser San Rafael-Gallinas | San Rafael | California | United States | 94903 |
| 70 | Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | United States | 95051 |
| 71 | Kaiser Permanente-Santa Rosa | Santa Rosa | California | United States | 95403 |
| 72 | City of Hope South Pasadena | South Pasadena | California | United States | 91030 |
| 73 | Kaiser Permanente Cancer Treatment Center | South San Francisco | California | United States | 94080 |
| 74 | Kaiser Permanente-South San Francisco | South San Francisco | California | United States | 94080 |
| 75 | Kaiser Permanente-Stockton | Stockton | California | United States | 95210 |
| 76 | Palo Alto Medical Foundation-Sunnyvale | Sunnyvale | California | United States | 94086 |
| 77 | Gene Upshaw Memorial Tahoe Forest Cancer Center | Truckee | California | United States | 96161 |
| 78 | City of Hope Upland | Upland | California | United States | 91786 |
| 79 | Sutter Cancer Centers Radiation Oncology Services-Vacaville | Vacaville | California | United States | 95687 |
| 80 | Kaiser Permanente Medical Center-Vacaville | Vacaville | California | United States | 95688 |
| 81 | Kaiser Permanente-Vallejo | Vallejo | California | United States | 94589 |
| 82 | Sutter Solano Medical Center/Cancer Center | Vallejo | California | United States | 94589 |
| 83 | Kaiser Permanente-Walnut Creek | Walnut Creek | California | United States | 94596 |
| 84 | Presbyterian Intercommunity Hospital | Whittier | California | United States | 90602 |
| 85 | Rocky Mountain Cancer Centers-Aurora | Aurora | Colorado | United States | 80012 |
| 86 | University of Colorado Hospital | Aurora | Colorado | United States | 80045 |
| 87 | Boulder Community Hospital | Boulder | Colorado | United States | 80301 |
| 88 | Rocky Mountain Cancer Centers-Boulder | Boulder | Colorado | United States | 80304 |
| 89 | Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | United States | 80907 |
| 90 | Rocky Mountain Cancer Centers-Penrose | Colorado Springs | Colorado | United States | 80907 |
| 91 | UCHealth Memorial Hospital Central | Colorado Springs | Colorado | United States | 80909 |
| 92 | Porter Adventist Hospital | Denver | Colorado | United States | 80210 |
| 93 | Presbyterian - Saint Lukes Medical Center - Health One | Denver | Colorado | United States | 80218 |
| 94 | SCL Health Saint Joseph Hospital | Denver | Colorado | United States | 80218 |
| 95 | Swedish Medical Center | Englewood | Colorado | United States | 80113 |
| 96 | Poudre Valley Hospital | Fort Collins | Colorado | United States | 80524 |
| 97 | Saint Mary's Hospital and Regional Medical Center | Grand Junction | Colorado | United States | 81501 |
| 98 | North Colorado Medical Center | Greeley | Colorado | United States | 80631 |
| 99 | Saint Anthony Hospital | Lakewood | Colorado | United States | 80228 |
| 100 | Rocky Mountain Cancer Centers-Littleton | Littleton | Colorado | United States | 80120 |
| 101 | Littleton Adventist Hospital | Littleton | Colorado | United States | 80122 |
| 102 | Longmont United Hospital | Longmont | Colorado | United States | 80501 |
| 103 | McKee Medical Center | Loveland | Colorado | United States | 80539 |
| 104 | Saint Mary Corwin Medical Center | Pueblo | Colorado | United States | 81004 |
| 105 | Rocky Mountain Cancer Centers-Thornton | Thornton | Colorado | United States | 80260 |
| 106 | SCL Health Lutheran Medical Center | Wheat Ridge | Colorado | United States | 80033 |
| 107 | Smilow Cancer Hospital Care Center - Guiford | Guilford | Connecticut | United States | 06437 |
| 108 | Hartford Hospital | Hartford | Connecticut | United States | 06102 |
| 109 | Midstate Medical Center | Meriden | Connecticut | United States | 06451 |
| 110 | The Hospital of Central Connecticut | New Britain | Connecticut | United States | 06050 |
| 111 | Smilow Cancer Center/Yale-New Haven Hospital | New Haven | Connecticut | United States | 06510 |
| 112 | Yale University | New Haven | Connecticut | United States | 06520 |
| 113 | Yale-New Haven Hospital North Haven Medical Center | North Haven | Connecticut | United States | 06473 |
| 114 | William Backus Hospital | Norwich | Connecticut | United States | 06360 |
| 115 | Smilow Cancer Hospital Care Center-Trumbull | Trumbull | Connecticut | United States | 06611 |
| 116 | Smilow Cancer Hospital Care Center - Waterford | Waterford | Connecticut | United States | 06385 |
| 117 | Beebe Medical Center | Lewes | Delaware | United States | 19958 |
| 118 | Delaware Clinical and Laboratory Physicians PA | Newark | Delaware | United States | 19713 |
| 119 | Helen F Graham Cancer Center | Newark | Delaware | United States | 19713 |
| 120 | Medical Oncology Hematology Consultants PA | Newark | Delaware | United States | 19713 |
| 121 | Christiana Care Health System-Christiana Hospital | Newark | Delaware | United States | 19718 |
| 122 | Beebe Health Campus | Rehoboth Beach | Delaware | United States | 19971 |
| 123 | TidalHealth Nanticoke / Allen Cancer Center | Seaford | Delaware | United States | 19973 |
| 124 | University of Florida Health Science Center - Gainesville | Gainesville | Florida | United States | 32610 |
| 125 | Mayo Clinic in Florida | Jacksonville | Florida | United States | 32224-9980 |
| 126 | Orlando Health Cancer Institute | Orlando | Florida | United States | 32806 |
| 127 | Emory University Hospital Midtown | Atlanta | Georgia | United States | 30308 |
| 128 | Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | United States | 30322 |
| 129 | Emory Saint Joseph's Hospital | Atlanta | Georgia | United States | 30342 |
| 130 | Northeast Georgia Medical Center-Gainesville | Gainesville | Georgia | United States | 30501 |
| 131 | Memorial Health University Medical Center | Savannah | Georgia | United States | 31404 |
| 132 | Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia | United States | 31405 |
| 133 | Pali Momi Medical Center | 'Aiea | Hawaii | United States | 96701 |
| 134 | Queen's Cancer Center - Pearlridge | 'Aiea | Hawaii | United States | 96701 |
| 135 | The Cancer Center of Hawaii-Pali Momi | 'Aiea | Hawaii | United States | 96701 |
| 136 | Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Hawaii | United States | 96813 |
| 137 | Island Urology | Honolulu | Hawaii | United States | 96813 |
| 138 | Queen's Medical Center | Honolulu | Hawaii | United States | 96813 |
| 139 | Straub Clinic and Hospital | Honolulu | Hawaii | United States | 96813 |
| 140 | University of Hawaii Cancer Center | Honolulu | Hawaii | United States | 96813 |
| 141 | Hawaii Cancer Care Inc-Liliha | Honolulu | Hawaii | United States | 96817 |
| 142 | Kuakini Medical Center | Honolulu | Hawaii | United States | 96817 |
| 143 | Queen's Cancer Center - Kuakini | Honolulu | Hawaii | United States | 96817 |
| 144 | The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii | United States | 96817 |
| 145 | Kaiser Permanente Moanalua Medical Center | Honolulu | Hawaii | United States | 96819 |
| 146 | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | United States | 96826 |
| 147 | Wilcox Memorial Hospital and Kauai Medical Clinic | Lihue | Hawaii | United States | 96766 |
| 148 | Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | United States | 83706 |
| 149 | Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | United States | 83605 |
| 150 | Idaho Urologic Institute-Meridian | Meridian | Idaho | United States | 83642 |
| 151 | Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | United States | 83854 |
| 152 | Northwest Community Hospital | Arlington Heights | Illinois | United States | 60005 |
| 153 | Rush - Copley Medical Center | Aurora | Illinois | United States | 60504 |
| 154 | Illinois CancerCare-Bloomington | Bloomington | Illinois | United States | 61704 |
| 155 | Memorial Hospital of Carbondale | Carbondale | Illinois | United States | 62902 |
| 156 | SIH Cancer Institute | Carterville | Illinois | United States | 62918 |
| 157 | Centralia Oncology Clinic | Centralia | Illinois | United States | 62801 |
| 158 | Northwestern University | Chicago | Illinois | United States | 60611 |
| 159 | University of Chicago Comprehensive Cancer Center | Chicago | Illinois | United States | 60637 |
| 160 | Advocate Illinois Masonic Medical Center | Chicago | Illinois | United States | 60657 |
| 161 | Carle on Vermilion | Danville | Illinois | United States | 61832 |
| 162 | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | United States | 62526 |
| 163 | Decatur Memorial Hospital | Decatur | Illinois | United States | 62526 |
| 164 | Carle Physician Group-Effingham | Effingham | Illinois | United States | 62401 |
| 165 | Crossroads Cancer Center | Effingham | Illinois | United States | 62401 |
| 166 | Western Illinois Cancer Treatment Center | Galesburg | Illinois | United States | 61401 |
| 167 | Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | United States | 60134 |
| 168 | Ingalls Memorial Hospital | Harvey | Illinois | United States | 60426 |
| 169 | Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois | United States | 60045 |
| 170 | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | United States | 61938 |
| 171 | Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
| 172 | Good Samaritan Regional Health Center | Mount Vernon | Illinois | United States | 62864 |
| 173 | UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois | United States | 60451 |
| 174 | Cancer Care Center of O'Fallon | O'Fallon | Illinois | United States | 62269 |
| 175 | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | United States | 61350 |
| 176 | OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center | Pekin | Illinois | United States | 61554 |
| 177 | Illinois CancerCare-Peoria | Peoria | Illinois | United States | 61615 |
| 178 | OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria | Illinois | United States | 61615 |
| 179 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
| 180 | OSF Saint Francis Medical Center | Peoria | Illinois | United States | 61637 |
| 181 | Illinois CancerCare-Peru | Peru | Illinois | United States | 61354 |
| 182 | Valley Radiation Oncology | Peru | Illinois | United States | 61354 |
| 183 | Illinois CancerCare-Princeton | Princeton | Illinois | United States | 61356 |
| 184 | SwedishAmerican Regional Cancer Center/ACT | Rockford | Illinois | United States | 61114 |
| 185 | Genesis Cancer Center - Silvis | Silvis | Illinois | United States | 61282 |
| 186 | Central Illinois Hematology Oncology Center | Springfield | Illinois | United States | 62702 |
| 187 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62702 |
| 188 | Springfield Clinic | Springfield | Illinois | United States | 62702 |
| 189 | Memorial Medical Center | Springfield | Illinois | United States | 62781 |
| 190 | Southwest Illinois Health Services LLP | Swansea | Illinois | United States | 62226 |
| 191 | Carle Cancer Center | Urbana | Illinois | United States | 61801 |
| 192 | Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | United States | 60555 |
| 193 | Deaconess Clinic Downtown | Evansville | Indiana | United States | 47713 |
| 194 | Parkview Hospital Randallia | Fort Wayne | Indiana | United States | 46805 |
| 195 | Parkview Regional Medical Center | Fort Wayne | Indiana | United States | 46845 |
| 196 | Goshen Center for Cancer Care | Goshen | Indiana | United States | 46526 |
| 197 | Franciscan Health Indianapolis | Indianapolis | Indiana | United States | 46237 |
| 198 | Woodland Cancer Care Center | Michigan City | Indiana | United States | 46360 |
| 199 | Memorial Regional Cancer Center Day Road | Mishawaka | Indiana | United States | 46545 |
| 200 | Franciscan Health Mooresville | Mooresville | Indiana | United States | 46158 |
| 201 | Chancellor Center for Oncology | Newburgh | Indiana | United States | 47630 |
| 202 | Reid Health | Richmond | Indiana | United States | 47374 |
| 203 | Memorial Hospital of South Bend | South Bend | Indiana | United States | 46601 |
| 204 | Mary Greeley Medical Center | Ames | Iowa | United States | 50010 |
| 205 | McFarland Clinic PC - Ames | Ames | Iowa | United States | 50010 |
| 206 | Mercy Hospital | Cedar Rapids | Iowa | United States | 52403 |
| 207 | Oncology Associates at Mercy Medical Center | Cedar Rapids | Iowa | United States | 52403 |
| 208 | Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa | United States | 50325 |
| 209 | Mercy Cancer Center-West Lakes | Clive | Iowa | United States | 50325 |
| 210 | Genesis Medical Center - East Campus | Davenport | Iowa | United States | 52803 |
| 211 | Genesis Cancer Care Institute | Davenport | Iowa | United States | 52804 |
| 212 | Iowa Cancer Specialists | Davenport | Iowa | United States | 52807 |
| 213 | Iowa Methodist Medical Center | Des Moines | Iowa | United States | 50309 |
| 214 | Medical Oncology and Hematology Associates-Des Moines | Des Moines | Iowa | United States | 50309 |
| 215 | Broadlawns Medical Center | Des Moines | Iowa | United States | 50314 |
| 216 | Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa | United States | 50314 |
| 217 | Mercy Medical Center - Des Moines | Des Moines | Iowa | United States | 50314 |
| 218 | Iowa Lutheran Hospital | Des Moines | Iowa | United States | 50316 |
| 219 | University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa | United States | 52242 |
| 220 | Methodist West Hospital | West Des Moines | Iowa | United States | 50266-7700 |
| 221 | Mercy Medical Center-West Lakes | West Des Moines | Iowa | United States | 50266 |
| 222 | Cancer Center of Kansas - Dodge City | Dodge City | Kansas | United States | 67801 |
| 223 | Cancer Center of Kansas - El Dorado | El Dorado | Kansas | United States | 67042 |
| 224 | Central Care Cancer Center - Garden City | Garden City | Kansas | United States | 67846 |
| 225 | Central Care Cancer Center - Great Bend | Great Bend | Kansas | United States | 67530 |
| 226 | University of Kansas Cancer Center | Kansas City | Kansas | United States | 66160 |
| 227 | Lawrence Memorial Hospital | Lawrence | Kansas | United States | 66044 |
| 228 | Olathe Health Cancer Center | Olathe | Kansas | United States | 66061 |
| 229 | University of Kansas Cancer Center-Overland Park | Overland Park | Kansas | United States | 66210 |
| 230 | Ascension Via Christi - Pittsburg | Pittsburg | Kansas | United States | 66762 |
| 231 | Cancer Center of Kansas - Salina | Salina | Kansas | United States | 67401 |
| 232 | Salina Regional Health Center | Salina | Kansas | United States | 67401 |
| 233 | Cotton O'Neil Cancer Center / Stormont Vail Health | Topeka | Kansas | United States | 66606 |
| 234 | University of Kansas Health System Saint Francis Campus | Topeka | Kansas | United States | 66606 |
| 235 | Cancer Center of Kansas - Wellington | Wellington | Kansas | United States | 67152 |
| 236 | University of Kansas Hospital-Westwood Cancer Center | Westwood | Kansas | United States | 66205 |
| 237 | Associates In Womens Health | Wichita | Kansas | United States | 67208 |
| 238 | Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas | United States | 67208 |
| 239 | Ascension Via Christi Hospitals Wichita | Wichita | Kansas | United States | 67214 |
| 240 | Cancer Center of Kansas - Wichita | Wichita | Kansas | United States | 67214 |
| 241 | Wesley Medical Center | Wichita | Kansas | United States | 67214 |
| 242 | Cancer Center of Kansas - Winfield | Winfield | Kansas | United States | 67156 |
| 243 | Saint Joseph Radiation Oncology Resource Center | Lexington | Kentucky | United States | 40504 |
| 244 | Saint Joseph Hospital East | Lexington | Kentucky | United States | 40509 |
| 245 | Jewish Hospital | Louisville | Kentucky | United States | 40202 |
| 246 | UofL Health Medical Center Northeast | Louisville | Kentucky | United States | 40245 |
| 247 | LSU Health Baton Rouge-North Clinic | Baton Rouge | Louisiana | United States | 70805 |
| 248 | Louisiana Hematology Oncology Associates LLC | Baton Rouge | Louisiana | United States | 70809 |
| 249 | Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | United States | 70809 |
| 250 | Our Lady of the Lake Physicians Group - Medical Oncology | Baton Rouge | Louisiana | United States | 70809 |
| 251 | Mary Bird Perkins Cancer Center - Covington | Covington | Louisiana | United States | 70433 |
| 252 | Northshore Oncology Associates-Covington | Covington | Louisiana | United States | 70433 |
| 253 | Mary Bird Perkins Cancer Center - Houma | Houma | Louisiana | United States | 70360 |
| 254 | Oncology Center of The South Incorporated | Houma | Louisiana | United States | 70360 |
| 255 | Ochsner Medical Center Jefferson | New Orleans | Louisiana | United States | 70121 |
| 256 | Eastern Maine Medical Center | Bangor | Maine | United States | 04401 |
| 257 | Lafayette Family Cancer Center-EMMC | Brewer | Maine | United States | 04412 |
| 258 | Greater Baltimore Medical Center | Baltimore | Maryland | United States | 21204 |
| 259 | TidalHealth Peninsula Regional | Salisbury | Maryland | United States | 21801 |
| 260 | Massachusetts General Hospital Cancer Center | Boston | Massachusetts | United States | 02114 |
| 261 | Brigham and Women's Hospital | Boston | Massachusetts | United States | 02115 |
| 262 | Beth Israel Deaconess Medical Center | Boston | Massachusetts | United States | 02215 |
| 263 | Dana-Farber Cancer Institute | Boston | Massachusetts | United States | 02215 |
| 264 | Berkshire Medical Center - Cancer Center | Pittsfield | Massachusetts | United States | 01201 |
| 265 | Hickman Cancer Center | Adrian | Michigan | United States | 49221 |
| 266 | Saint Joseph Mercy Hospital | Ann Arbor | Michigan | United States | 48106 |
| 267 | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | United States | 48109 |
| 268 | Bronson Battle Creek | Battle Creek | Michigan | United States | 49017 |
| 269 | McLaren Cancer Institute-Bay City | Bay City | Michigan | United States | 48706 |
| 270 | Henry Ford Cancer Institute-Downriver | Brownstown | Michigan | United States | 48183 |
| 271 | McLaren Cancer Institute-Clarkston | Clarkston | Michigan | United States | 48346 |
| 272 | Henry Ford Macomb Hospital-Clinton Township | Clinton Township | Michigan | United States | 48038 |
| 273 | Beaumont Hospital - Dearborn | Dearborn | Michigan | United States | 48124 |
| 274 | Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | United States | 48201 |
| 275 | Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
| 276 | Ascension Saint John Hospital | Detroit | Michigan | United States | 48236 |
| 277 | Weisberg Cancer Treatment Center | Farmington Hills | Michigan | United States | 48334 |
| 278 | Beaumont Hospital - Farmington Hills | Farmington Hills | Michigan | United States | 48336 |
| 279 | Genesys Hurley Cancer Institute | Flint | Michigan | United States | 48503 |
| 280 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
| 281 | McLaren Cancer Institute-Flint | Flint | Michigan | United States | 48532 |
| 282 | Singh and Arora Hematology Oncology PC | Flint | Michigan | United States | 48532 |
| 283 | Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids | Michigan | United States | 49503 |
| 284 | Mercy Health Saint Mary's | Grand Rapids | Michigan | United States | 49503 |
| 285 | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | United States | 49503 |
| 286 | Allegiance Health | Jackson | Michigan | United States | 49201 |
| 287 | Bronson Methodist Hospital | Kalamazoo | Michigan | United States | 49007 |
| 288 | West Michigan Cancer Center | Kalamazoo | Michigan | United States | 49007 |
| 289 | Borgess Medical Center | Kalamazoo | Michigan | United States | 49048 |
| 290 | Karmanos Cancer Institute at McLaren Greater Lansing | Lansing | Michigan | United States | 48910 |
| 291 | Sparrow Hospital | Lansing | Michigan | United States | 48912 |
| 292 | McLaren Cancer Institute-Lapeer Region | Lapeer | Michigan | United States | 48446 |
| 293 | Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | United States | 48154 |
| 294 | McLaren Cancer Institute-Macomb | Mount Clemens | Michigan | United States | 48043 |
| 295 | McLaren Cancer Institute-Central Michigan | Mount Pleasant | Michigan | United States | 48858 |
| 296 | Mercy Health Mercy Campus | Muskegon | Michigan | United States | 49444 |
| 297 | Lakeland Hospital Niles | Niles | Michigan | United States | 49120 |
| 298 | Ascension Providence Hospitals - Novi | Novi | Michigan | United States | 48374 |
| 299 | McLaren Cancer Institute-Owosso | Owosso | Michigan | United States | 48867 |
| 300 | McLaren Cancer Institute-Northern Michigan | Petoskey | Michigan | United States | 49770 |
| 301 | 21st Century Oncology-Pontiac | Pontiac | Michigan | United States | 48341 |
| 302 | Saint Joseph Mercy Oakland | Pontiac | Michigan | United States | 48341 |
| 303 | McLaren-Port Huron | Port Huron | Michigan | United States | 48060 |
| 304 | Spectrum Health Reed City Hospital | Reed City | Michigan | United States | 49677 |
| 305 | William Beaumont Hospital-Royal Oak | Royal Oak | Michigan | United States | 48073 |
| 306 | Ascension Saint Mary's Hospital | Saginaw | Michigan | United States | 48601 |
| 307 | Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan | United States | 49085 |
| 308 | Marie Yeager Cancer Center | Saint Joseph | Michigan | United States | 49085 |
| 309 | Ascension Providence Hospitals - Southfield | Southfield | Michigan | United States | 48075 |
| 310 | Munson Medical Center | Traverse City | Michigan | United States | 49684 |
| 311 | William Beaumont Hospital - Troy | Troy | Michigan | United States | 48085 |
| 312 | Saint John Macomb-Oakland Hospital | Warren | Michigan | United States | 48093 |
| 313 | Henry Ford West Bloomfield Hospital | West Bloomfield | Michigan | United States | 48322 |
| 314 | Metro Health Hospital | Wyoming | Michigan | United States | 49519 |
| 315 | Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | United States | 56601 |
| 316 | Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota | United States | 56401 |
| 317 | Fairview Ridges Hospital | Burnsville | Minnesota | United States | 55337 |
| 318 | Mercy Hospital | Coon Rapids | Minnesota | United States | 55433 |
| 319 | Essentia Health - Deer River Clinic | Deer River | Minnesota | United States | 56636 |
| 320 | Essentia Health Saint Mary's - Detroit Lakes Clinic | Detroit Lakes | Minnesota | United States | 56501 |
| 321 | Essentia Health Cancer Center | Duluth | Minnesota | United States | 55805 |
| 322 | Essentia Health Saint Mary's Medical Center | Duluth | Minnesota | United States | 55805 |
| 323 | Miller-Dwan Hospital | Duluth | Minnesota | United States | 55805 |
| 324 | Saint Luke's Hospital of Duluth | Duluth | Minnesota | United States | 55805 |
| 325 | Fairview Southdale Hospital | Edina | Minnesota | United States | 55435 |
| 326 | Lake Region Healthcare Corporation-Cancer Care | Fergus Falls | Minnesota | United States | 56537 |
| 327 | Essentia Health - Fosston | Fosston | Minnesota | United States | 56542 |
| 328 | Unity Hospital | Fridley | Minnesota | United States | 55432 |
| 329 | Essentia Health Hibbing Clinic | Hibbing | Minnesota | United States | 55746 |
| 330 | Fairview Clinics and Surgery Center Maple Grove | Maple Grove | Minnesota | United States | 55369 |
| 331 | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | United States | 55109 |
| 332 | Saint John's Hospital - Healtheast | Maplewood | Minnesota | United States | 55109 |
| 333 | Abbott-Northwestern Hospital | Minneapolis | Minnesota | United States | 55407 |
| 334 | Hennepin County Medical Center | Minneapolis | Minnesota | United States | 55415 |
| 335 | Health Partners Inc | Minneapolis | Minnesota | United States | 55454 |
| 336 | Monticello Cancer Center | Monticello | Minnesota | United States | 55362 |
| 337 | Essentia Health - Park Rapids | Park Rapids | Minnesota | United States | 56470 |
| 338 | North Memorial Medical Health Center | Robbinsdale | Minnesota | United States | 55422 |
| 339 | Mayo Clinic in Rochester | Rochester | Minnesota | United States | 55905 |
| 340 | Coborn Cancer Center at Saint Cloud Hospital | Saint Cloud | Minnesota | United States | 56303 |
| 341 | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | United States | 55416 |
| 342 | Regions Hospital | Saint Paul | Minnesota | United States | 55101 |
| 343 | United Hospital | Saint Paul | Minnesota | United States | 55102 |
| 344 | Essentia Health Sandstone | Sandstone | Minnesota | United States | 55072 |
| 345 | Saint Francis Regional Medical Center | Shakopee | Minnesota | United States | 55379 |
| 346 | Lakeview Hospital | Stillwater | Minnesota | United States | 55082 |
| 347 | Essentia Health Virginia Clinic | Virginia | Minnesota | United States | 55792 |
| 348 | Ridgeview Medical Center | Waconia | Minnesota | United States | 55387 |
| 349 | Rice Memorial Hospital | Willmar | Minnesota | United States | 56201 |
| 350 | Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | United States | 55125 |
| 351 | Baptist Cancer Center-Grenada | Grenada | Mississippi | United States | 38901 |
| 352 | Baptist Memorial Hospital and Cancer Center-Union County | New Albany | Mississippi | United States | 38652 |
| 353 | Baptist Memorial Hospital and Cancer Center-Oxford | Oxford | Mississippi | United States | 38655 |
| 354 | Baptist Memorial Hospital and Cancer Center-Desoto | Southhaven | Mississippi | United States | 38671 |
| 355 | Saint Louis Cancer and Breast Institute-Ballwin | Ballwin | Missouri | United States | 63011 |
| 356 | Central Care Cancer Center - Bolivar | Bolivar | Missouri | United States | 65613 |
| 357 | Parkland Health Center-Bonne Terre | Bonne Terre | Missouri | United States | 63628 |
| 358 | Saint Francis Medical Center | Cape Girardeau | Missouri | United States | 63703 |
| 359 | Southeast Cancer Center | Cape Girardeau | Missouri | United States | 63703 |
| 360 | Capital Region Southwest Campus | Jefferson City | Missouri | United States | 65109 |
| 361 | Freeman Health System | Joplin | Missouri | United States | 64804 |
| 362 | Research Medical Center | Kansas City | Missouri | United States | 64132 |
| 363 | University of Kansas Cancer Center - North | Kansas City | Missouri | United States | 64154 |
| 364 | University of Kansas Cancer Center - Lee's Summit | Lee's Summit | Missouri | United States | 64064 |
| 365 | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | United States | 65401 |
| 366 | Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | United States | 65401 |
| 367 | Heartland Regional Medical Center | Saint Joseph | Missouri | United States | 64506 |
| 368 | Mercy Hospital South | Saint Louis | Missouri | United States | 63128 |
| 369 | Missouri Baptist Medical Center | Saint Louis | Missouri | United States | 63131 |
| 370 | Mercy Hospital Saint Louis | Saint Louis | Missouri | United States | 63141 |
| 371 | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | United States | 63670 |
| 372 | Mercy Hospital Springfield | Springfield | Missouri | United States | 65804 |
| 373 | CoxHealth South Hospital | Springfield | Missouri | United States | 65807 |
| 374 | Missouri Baptist Sullivan Hospital | Sullivan | Missouri | United States | 63080 |
| 375 | Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri | United States | 63127 |
| 376 | Billings Clinic Cancer Center | Billings | Montana | United States | 59101 |
| 377 | Saint Vincent Healthcare | Billings | Montana | United States | 59101 |
| 378 | Bozeman Deaconess Hospital | Bozeman | Montana | United States | 59715 |
| 379 | Saint James Community Hospital and Cancer Treatment Center | Butte | Montana | United States | 59701 |
| 380 | Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | United States | 59405 |
| 381 | Great Falls Clinic | Great Falls | Montana | United States | 59405 |
| 382 | Kalispell Regional Medical Center | Kalispell | Montana | United States | 59901 |
| 383 | Community Medical Hospital | Missoula | Montana | United States | 59804 |
| 384 | CHI Health Saint Francis | Grand Island | Nebraska | United States | 68803 |
| 385 | CHI Health Good Samaritan | Kearney | Nebraska | United States | 68847 |
| 386 | Nebraska Hematology and Oncology | Lincoln | Nebraska | United States | 68506 |
| 387 | Nebraska Cancer Research Center | Lincoln | Nebraska | United States | 68510 |
| 388 | Southeast Nebraska Cancer Center - 68th Street Place | Lincoln | Nebraska | United States | 68516 |
| 389 | Alegent Health Immanuel Medical Center | Omaha | Nebraska | United States | 68122 |
| 390 | Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska | United States | 68124 |
| 391 | Nebraska Cancer Specialists - Omaha | Omaha | Nebraska | United States | 68124 |
| 392 | Alegent Health Lakeside Hospital | Omaha | Nebraska | United States | 68130 |
| 393 | Creighton University Medical Center | Omaha | Nebraska | United States | 68131 |
| 394 | Regional West Medical Center Cancer Center | Scottsbluff | Nebraska | United States | 69361 |
| 395 | OptumCare Cancer Care at Seven Hills | Henderson | Nevada | United States | 89052 |
| 396 | OptumCare Cancer Care at Charleston | Las Vegas | Nevada | United States | 89102 |
| 397 | Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada | United States | 89106 |
| 398 | GenesisCare USA - Las Vegas | Las Vegas | Nevada | United States | 89109 |
| 399 | OptumCare Cancer Care at MountainView | Las Vegas | Nevada | United States | 89128 |
| 400 | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | United States | 89148 |
| 401 | OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 402 | Renown Regional Medical Center | Reno | Nevada | United States | 89502 |
| 403 | Saint Mary's Regional Medical Center | Reno | Nevada | United States | 89503 |
| 404 | Radiation Oncology Associates | Reno | Nevada | United States | 89509 |
| 405 | Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | United States | 03756 |
| 406 | Englewood Hospital and Medical Center | Englewood | New Jersey | United States | 07631 |
| 407 | Virtua Samson Cancer Center | Moorestown | New Jersey | United States | 08057 |
| 408 | Virtua Memorial | Mount Holly | New Jersey | United States | 08060 |
| 409 | Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | United States | 08903 |
| 410 | Robert Wood Johnson University Hospital Somerset | Somerville | New Jersey | United States | 08876 |
| 411 | Holy Name Hospital | Teaneck | New Jersey | United States | 07666 |
| 412 | Virtua Voorhees | Voorhees | New Jersey | United States | 08043 |
| 413 | University of New Mexico Cancer Center | Albuquerque | New Mexico | United States | 87102 |
| 414 | New Mexico Oncology Hematology Consultants | Albuquerque | New Mexico | United States | 87109 |
| 415 | Christus Saint Vincent Regional Cancer Center | Santa Fe | New Mexico | United States | 87505 |
| 416 | Northwell Health Imbert Cancer Center | Bay Shore | New York | United States | 11706 |
| 417 | Montefiore Medical Center-Einstein Campus | Bronx | New York | United States | 10461 |
| 418 | Montefiore Medical Center-Weiler Hospital | Bronx | New York | United States | 10461 |
| 419 | Montefiore Medical Center - Moses Campus | Bronx | New York | United States | 10467 |
| 420 | Glens Falls Hospital | Glens Falls | New York | United States | 12801 |
| 421 | Northwell Health/Center for Advanced Medicine | Lake Success | New York | United States | 11042 |
| 422 | North Shore University Hospital | Manhasset | New York | United States | 11030 |
| 423 | Garnet Health Medical Center | Middletown | New York | United States | 10940 |
| 424 | Long Island Jewish Medical Center | New Hyde Park | New York | United States | 11040 |
| 425 | Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York | United States | 10016 |
| 426 | University of Rochester | Rochester | New York | United States | 14642 |
| 427 | Staten Island University Hospital | Staten Island | New York | United States | 10305 |
| 428 | State University of New York Upstate Medical University | Syracuse | New York | United States | 13210 |
| 429 | Atrium Health Stanly/LCI-Albemarle | Albemarle | North Carolina | United States | 28002 |
| 430 | Mission Hospital | Asheville | North Carolina | United States | 28801 |
| 431 | Carolinas Medical Center/Levine Cancer Institute | Charlotte | North Carolina | United States | 28203 |
| 432 | Novant Health Presbyterian Medical Center | Charlotte | North Carolina | United States | 28204 |
| 433 | Atrium Health Pineville/LCI-Pineville | Charlotte | North Carolina | United States | 28210 |
| 434 | Atrium Health University City/LCI-University | Charlotte | North Carolina | United States | 28262 |
| 435 | Atrium Health Cabarrus/LCI-Concord | Concord | North Carolina | United States | 28025 |
| 436 | Novant Health Presbyterian Medical Center Huntersville | Huntersville | North Carolina | United States | 28078 |
| 437 | Matthews Radiation Oncology Center | Matthews | North Carolina | United States | 28105 |
| 438 | Atrium Health Union/LCI-Union | Monroe | North Carolina | United States | 28112 |
| 439 | UNC Rex Cancer Center | Raleigh | North Carolina | United States | 27607 |
| 440 | Atrium Health Cleveland/LCI-Cleveland | Shelby | North Carolina | United States | 28150 |
| 441 | Wake Forest University Health Sciences | Winston-Salem | North Carolina | United States | 27157 |
| 442 | Sanford Bismarck Medical Center | Bismarck | North Dakota | United States | 58501 |
| 443 | Essentia Health Cancer Center-South University Clinic | Fargo | North Dakota | United States | 58103 |
| 444 | Sanford Broadway Medical Center | Fargo | North Dakota | United States | 58122 |
| 445 | Sanford Roger Maris Cancer Center | Fargo | North Dakota | United States | 58122 |
| 446 | Essentia Health - Jamestown Clinic | Jamestown | North Dakota | United States | 58401 |
| 447 | Cleveland Clinic Akron General | Akron | Ohio | United States | 44307 |
| 448 | UHHS-Chagrin Highlands Medical Center | Beachwood | Ohio | United States | 44122 |
| 449 | Indu and Raj Soin Medical Center | Beavercreek | Ohio | United States | 45431 |
| 450 | Cleveland Clinic Mercy Hospital | Canton | Ohio | United States | 44708 |
| 451 | Dayton Physicians LLC-Miami Valley South | Centerville | Ohio | United States | 45459 |
| 452 | Miami Valley Hospital South | Centerville | Ohio | United States | 45459 |
| 453 | Geauga Hospital | Chardon | Ohio | United States | 44024 |
| 454 | University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | United States | 45219 |
| 455 | Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio | United States | 45220 |
| 456 | Oncology Hematology Care Inc-Kenwood | Cincinnati | Ohio | United States | 45236 |
| 457 | Bethesda North Hospital | Cincinnati | Ohio | United States | 45242 |
| 458 | Case Western Reserve University | Cleveland | Ohio | United States | 44106 |
| 459 | Ohio State University Comprehensive Cancer Center | Columbus | Ohio | United States | 43210 |
| 460 | Good Samaritan Hospital - Dayton | Dayton | Ohio | United States | 45406 |
| 461 | Miami Valley Hospital | Dayton | Ohio | United States | 45409 |
| 462 | Dayton Physician LLC-Miami Valley Hospital North | Dayton | Ohio | United States | 45415 |
| 463 | Miami Valley Hospital North | Dayton | Ohio | United States | 45415 |
| 464 | Mercy Cancer Center-Elyria | Elyria | Ohio | United States | 44035 |
| 465 | Armes Family Cancer Center | Findlay | Ohio | United States | 45840 |
| 466 | Blanchard Valley Hospital | Findlay | Ohio | United States | 45840 |
| 467 | Orion Cancer Care | Findlay | Ohio | United States | 45840 |
| 468 | Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | United States | 45005-1066 |
| 469 | Dayton Physicians LLC-Atrium | Franklin | Ohio | United States | 45005 |
| 470 | Dayton Physicians LLC-Wayne | Greenville | Ohio | United States | 45331 |
| 471 | Wayne Hospital | Greenville | Ohio | United States | 45331 |
| 472 | Greater Dayton Cancer Center | Kettering | Ohio | United States | 45409 |
| 473 | Kettering Medical Center | Kettering | Ohio | United States | 45429 |
| 474 | Toledo Clinic Cancer Centers-Maumee | Maumee | Ohio | United States | 43537 |
| 475 | UH Seidman Cancer Center at Lake Health Mentor Campus | Mentor | Ohio | United States | 44060 |
| 476 | UH Seidman Cancer Center at Southwest General Hospital | Middleburg Heights | Ohio | United States | 44130 |
| 477 | University Hospitals Parma Medical Center | Parma | Ohio | United States | 44129 |
| 478 | University Hospitals Portage Medical Center | Ravenna | Ohio | United States | 44266 |
| 479 | UH Seidman Cancer Center at Firelands Regional Medical Center | Sandusky | Ohio | United States | 44870 |
| 480 | Springfield Regional Cancer Center | Springfield | Ohio | United States | 45504 |
| 481 | Springfield Regional Medical Center | Springfield | Ohio | United States | 45505 |
| 482 | ProMedica Flower Hospital | Sylvania | Ohio | United States | 43560 |
| 483 | ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital | Toledo | Ohio | United States | 43606 |
| 484 | Mercy Health - Saint Anne Hospital | Toledo | Ohio | United States | 43623 |
| 485 | Toledo Clinic Cancer Centers-Toledo | Toledo | Ohio | United States | 43623 |
| 486 | Dayton Physicians LLC-Upper Valley | Troy | Ohio | United States | 45373 |
| 487 | Upper Valley Medical Center | Troy | Ohio | United States | 45373 |
| 488 | University Hospitals Sharon Health Center | Wadsworth | Ohio | United States | 44281 |
| 489 | University of Cincinnati Cancer Center-West Chester | West Chester | Ohio | United States | 45069 |
| 490 | UH Seidman Cancer Center at Saint John Medical Center | Westlake | Ohio | United States | 44145 |
| 491 | UHHS-Westlake Medical Center | Westlake | Ohio | United States | 44145 |
| 492 | Cancer Centers of Southwest Oklahoma Research | Lawton | Oklahoma | United States | 73505 |
| 493 | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 494 | Integris Southwest Medical Center | Oklahoma City | Oklahoma | United States | 73109 |
| 495 | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | United States | 73120 |
| 496 | Integris Cancer Institute of Oklahoma | Oklahoma City | Oklahoma | United States | 73142 |
| 497 | Legacy Mount Hood Medical Center | Gresham | Oregon | United States | 97030 |
| 498 | Legacy Good Samaritan Hospital and Medical Center | Portland | Oregon | United States | 97210 |
| 499 | Kaiser Permanente Northwest | Portland | Oregon | United States | 97227 |
| 500 | Jefferson Abington Hospital | Abington | Pennsylvania | United States | 19001 |
| 501 | Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | United States | 18103 |
| 502 | Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania | United States | 18017 |
| 503 | Crozer-Keystone Regional Cancer Center at Broomall | Broomall | Pennsylvania | United States | 19008 |
| 504 | Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania | United States | 19317 |
| 505 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822 |
| 506 | Northeast Radiation Oncology Center | Dunmore | Pennsylvania | United States | 18512 |
| 507 | Pocono Medical Center | East Stroudsburg | Pennsylvania | United States | 18301 |
| 508 | Saint Vincent Hospital | Erie | Pennsylvania | United States | 16544 |
| 509 | Crozer Regional Cancer Center at Brinton Lake | Glen Mills | Pennsylvania | United States | 19342 |
| 510 | Jefferson Hospital | Jefferson Hills | Pennsylvania | United States | 15025 |
| 511 | Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania | United States | 17837 |
| 512 | Lewistown Hospital | Lewistown | Pennsylvania | United States | 17044 |
| 513 | Forbes Hospital | Monroeville | Pennsylvania | United States | 15146 |
| 514 | Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | United States | 19107 |
| 515 | Fox Chase Cancer Center | Philadelphia | Pennsylvania | United States | 19111 |
| 516 | Temple University Hospital | Philadelphia | Pennsylvania | United States | 19140 |
| 517 | Allegheny General Hospital | Pittsburgh | Pennsylvania | United States | 15212 |
| 518 | Geisinger Medical Oncology-Selinsgrove | Selinsgrove | Pennsylvania | United States | 17870 |
| 519 | Grand View Hospital | Sellersville | Pennsylvania | United States | 18960 |
| 520 | Reading Hospital | West Reading | Pennsylvania | United States | 19611 |
| 521 | Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | United States | 18711 |
| 522 | Asplundh Cancer Pavilion | Willow Grove | Pennsylvania | United States | 19090 |
| 523 | Lankenau Medical Center | Wynnewood | Pennsylvania | United States | 19096 |
| 524 | AnMed Health Cancer Center | Anderson | South Carolina | United States | 29621 |
| 525 | Prisma Health Cancer Institute - Spartanburg | Boiling Springs | South Carolina | United States | 29316 |
| 526 | Medical University of South Carolina | Charleston | South Carolina | United States | 29425 |
| 527 | Gibbs Cancer Center-Gaffney | Gaffney | South Carolina | United States | 29341 |
| 528 | Prisma Health Cancer Institute - Faris | Greenville | South Carolina | United States | 29605 |
| 529 | Prisma Health Cancer Institute - Eastside | Greenville | South Carolina | United States | 29615 |
| 530 | Prisma Health Cancer Institute - Greer | Greer | South Carolina | United States | 29650 |
| 531 | Gibbs Cancer Center-Pelham | Greer | South Carolina | United States | 29651 |
| 532 | Rock Hill Radiation Therapy Center | Rock Hill | South Carolina | United States | 29730 |
| 533 | Levine Cancer Institute-Rock Hill | Rock Hill | South Carolina | United States | 29732 |
| 534 | Prisma Health Cancer Institute - Seneca | Seneca | South Carolina | United States | 29672 |
| 535 | Spartanburg Medical Center | Spartanburg | South Carolina | United States | 29303 |
| 536 | MGC Hematology Oncology-Union | Union | South Carolina | United States | 29379 |
| 537 | Avera Cancer Institute-Aberdeen | Aberdeen | South Dakota | United States | 57401 |
| 538 | Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | United States | 57104 |
| 539 | Avera Cancer Institute | Sioux Falls | South Dakota | United States | 57105 |
| 540 | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | United States | 57117-5134 |
| 541 | Memorial Hospital | Chattanooga | Tennessee | United States | 37404 |
| 542 | Baptist Memorial Hospital and Cancer Center-Collierville | Collierville | Tennessee | United States | 38017 |
| 543 | The West Clinic - Wolf River | Germantown | Tennessee | United States | 38138 |
| 544 | The West Clinic - Mid-Town | Memphis | Tennessee | United States | 38104 |
| 545 | Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Tennessee | United States | 38120 |
| 546 | University of Tennessee Health Science Center | Memphis | Tennessee | United States | 38163 |
| 547 | Vanderbilt Breast Center at One Hundred Oaks | Nashville | Tennessee | United States | 37204 |
| 548 | Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | United States | 37232 |
| 549 | Saint Joseph Regional Cancer Center | Bryan | Texas | United States | 77802 |
| 550 | Parkland Memorial Hospital | Dallas | Texas | United States | 75235 |
| 551 | Baylor University Medical Center | Dallas | Texas | United States | 75246 |
| 552 | UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | United States | 75390 |
| 553 | University of Texas Medical Branch | Galveston | Texas | United States | 77555-0565 |
| 554 | Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Houston | Texas | United States | 77030 |
| 555 | Ben Taub General Hospital | Houston | Texas | United States | 77030 |
| 556 | M D Anderson Cancer Center | Houston | Texas | United States | 77030 |
| 557 | UTMB Cancer Center at Victory Lakes | League City | Texas | United States | 77573 |
| 558 | Covenant Medical Center-Lakeside | Lubbock | Texas | United States | 79410 |
| 559 | Scott and White Memorial Hospital | Temple | Texas | United States | 76508 |
| 560 | Sandra L Maxwell Cancer Center | Cedar City | Utah | United States | 84720 |
| 561 | Logan Regional Hospital | Logan | Utah | United States | 84321 |
| 562 | Intermountain Medical Center | Murray | Utah | United States | 84107 |
| 563 | McKay-Dee Hospital Center | Ogden | Utah | United States | 84403 |
| 564 | Utah Valley Regional Medical Center | Provo | Utah | United States | 84604 |
| 565 | Riverton Hospital | Riverton | Utah | United States | 84065 |
| 566 | Saint George Regional Medical Center | Saint George | Utah | United States | 84770 |
| 567 | Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah | United States | 84106 |
| 568 | LDS Hospital | Salt Lake City | Utah | United States | 84143 |
| 569 | Central Vermont Medical Center/National Life Cancer Treatment | Berlin | Vermont | United States | 05602 |
| 570 | University of Vermont Medical Center | Burlington | Vermont | United States | 05401 |
| 571 | University of Vermont and State Agricultural College | Burlington | Vermont | United States | 05405 |
| 572 | Norris Cotton Cancer Center-North | Saint Johnsbury | Vermont | United States | 05819 |
| 573 | Sentara Cancer Institute at Sentara CarePlex Hospital | Hampton | Virginia | United States | 23666 |
| 574 | Sentara Leigh Hospital | Norfolk | Virginia | United States | 23502 |
| 575 | Sentara Norfolk General Hospital | Norfolk | Virginia | United States | 23507 |
| 576 | Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia | United States | 23298 |
| 577 | MultiCare Auburn Medical Center | Auburn | Washington | United States | 98001 |
| 578 | Overlake Medical Center | Bellevue | Washington | United States | 98004 |
| 579 | Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington | United States | 98310 |
| 580 | Harrison Medical Center | Bremerton | Washington | United States | 98310 |
| 581 | Highline Medical Center-Main Campus | Burien | Washington | United States | 98166 |
| 582 | Virginia Mason Federal Way Medical Center | Federal Way | Washington | United States | 98002 |
| 583 | Tacoma/Valley Radiation Oncology Centers-Gig Harbor | Gig Harbor | Washington | United States | 98332 |
| 584 | MultiCare Gig Harbor Medical Park | Gig Harbor | Washington | United States | 98335 |
| 585 | Tri-Cities Cancer Center | Kennewick | Washington | United States | 99336 |
| 586 | Seattle Cancer Care Alliance at EvergreenHealth | Kirkland | Washington | United States | 98034 |
| 587 | Skagit Regional Health Cancer Care Center | Mount Vernon | Washington | United States | 98274 |
| 588 | Skagit Valley Hospital | Mount Vernon | Washington | United States | 98274 |
| 589 | MultiCare Good Samaritan Hospital | Puyallup | Washington | United States | 98372 |
| 590 | Tacoma/Valley Radiation Oncology Centers-Puyallup | Puyallup | Washington | United States | 98372 |
| 591 | Valley Medical Center | Renton | Washington | United States | 98055 |
| 592 | Virginia Mason Medical Center | Seattle | Washington | United States | 98101 |
| 593 | Fred Hutchinson Cancer Research Center | Seattle | Washington | United States | 98109 |
| 594 | Seattle Cancer Care Alliance | Seattle | Washington | United States | 98109 |
| 595 | Seattle Cancer Care Alliance at Northwest Hospital | Seattle | Washington | United States | 98133 |
| 596 | University of Washington Medical Center - Montlake | Seattle | Washington | United States | 98195 |
| 597 | Spokane Valley Cancer Center-Mayfair | Spokane | Washington | United States | 99208 |
| 598 | MultiCare Tacoma General Hospital | Tacoma | Washington | United States | 98405 |
| 599 | Northwest Medical Specialties PLLC | Tacoma | Washington | United States | 98405 |
| 600 | Tacoma/Valley Radiation Oncology Centers-Saint Joe's | Tacoma | Washington | United States | 98405 |
| 601 | Legacy Salmon Creek Hospital | Vancouver | Washington | United States | 98686 |
| 602 | Wenatchee Valley Hospital and Clinics | Wenatchee | Washington | United States | 98801 |
| 603 | North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima | Washington | United States | 98902 |
| 604 | United Hospital Center | Bridgeport | West Virginia | United States | 26330 |
| 605 | West Virginia University Charleston Division | Charleston | West Virginia | United States | 25304 |
| 606 | West Virginia University Healthcare | Morgantown | West Virginia | United States | 26506 |
| 607 | Camden Clark Medical Center | Parkersburg | West Virginia | United States | 26101 |
| 608 | Wheeling Hospital/Schiffler Cancer Center | Wheeling | West Virginia | United States | 26003 |
| 609 | Duluth Clinic Ashland | Ashland | Wisconsin | United States | 54806 |
| 610 | Northwest Wisconsin Cancer Center | Ashland | Wisconsin | United States | 54806 |
| 611 | Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin | United States | 53105 |
| 612 | Marshfield Clinic Cancer Center at Sacred Heart | Eau Claire | Wisconsin | United States | 54701 |
| 613 | Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin | United States | 54701 |
| 614 | Aurora Health Center-Fond du Lac | Fond Du Lac | Wisconsin | United States | 54937 |
| 615 | Aurora Health Care Germantown Health Center | Germantown | Wisconsin | United States | 53022 |
| 616 | Aurora Cancer Care-Grafton | Grafton | Wisconsin | United States | 53024 |
| 617 | Aurora BayCare Medical Center | Green Bay | Wisconsin | United States | 54311 |
| 618 | UW Cancer Center Johnson Creek | Johnson Creek | Wisconsin | United States | 53038 |
| 619 | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | United States | 53142 |
| 620 | University of Wisconsin Carbone Cancer Center | Madison | Wisconsin | United States | 53792 |
| 621 | Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin | United States | 54143 |
| 622 | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | United States | 54449 |
| 623 | Froedtert Menomonee Falls Hospital | Menomonee Falls | Wisconsin | United States | 53051 |
| 624 | Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin | United States | 53209 |
| 625 | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | United States | 53215 |
| 626 | Medical College of Wisconsin | Milwaukee | Wisconsin | United States | 53226 |
| 627 | Aurora Sinai Medical Center | Milwaukee | Wisconsin | United States | 53233 |
| 628 | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin | United States | 54548 |
| 629 | ProHealth D N Greenwald Center | Mukwonago | Wisconsin | United States | 53149 |
| 630 | Cancer Center of Western Wisconsin | New Richmond | Wisconsin | United States | 54017 |
| 631 | ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | United States | 53066 |
| 632 | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | United States | 54904 |
| 633 | Aurora Cancer Care-Racine | Racine | Wisconsin | United States | 53406 |
| 634 | Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | United States | 54868 |
| 635 | Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin | United States | 53081 |
| 636 | Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Wisconsin | United States | 54482 |
| 637 | Aurora Medical Center in Summit | Summit | Wisconsin | United States | 53066 |
| 638 | Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin | United States | 54241 |
| 639 | UW Cancer Center at ProHealth Care | Waukesha | Wisconsin | United States | 53188 |
| 640 | Marshfield Clinic-Wausau Center | Wausau | Wisconsin | United States | 54401 |
| 641 | Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin | United States | 53226 |
| 642 | Aurora West Allis Medical Center | West Allis | Wisconsin | United States | 53227 |
| 643 | Froedtert West Bend Hospital/Kraemer Cancer Center | West Bend | Wisconsin | United States | 53095 |
| 644 | Diagnostic and Treatment Center | Weston | Wisconsin | United States | 54476 |
| 645 | Marshfield Medical Center - Weston | Weston | Wisconsin | United States | 54476 |
| 646 | Cancer Center-Metro Medical Center Bayamon | Bayamon | Puerto Rico | 00959-5060 | |
| 647 | Doctors Cancer Center | Manati | Puerto Rico | 00674 | |
| 648 | San Juan Community Oncology Group | San Juan | Puerto Rico | 00917 | |
| 649 | Centro Comprensivo de Cancer de UPR | San Juan | Puerto Rico | 00927 | |
| 650 | San Juan City Hospital | San Juan | Puerto Rico | 00936 |
Sponsors and Collaborators
- National Cancer Institute (NCI)
- NRG Oncology
Investigators
- Principal Investigator: Thomas J George, NRG Oncology
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NCI-2016-00222
- NCI-2016-00222
- NRG-GI002
- s17-00197
- NRG-GI002
- NRG-GI002
- U10CA180868