Reduction of Risk for Cardiovascular Diseases
Study Details
Study Description
Brief Summary
To establish and evaluate a new prediction model for assessing cardiovascular disease risk in community-dwelling adults.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
|
Detailed Description
This is an ambispective, observational cohort study. In the retrospective part, we will enroll residents from Guangzhou or Foshan who participated in the annual health checks provided by the Chinese National Basic Public Health Service project between January 2015 and December 2019. The demographic characteristics, anthropometric measurements, laboratory assays, medical history, living habits, and medications will be collected through personal electronic health records obtained from the regional chronic disease management platform. In the prospective part, residents who participated in the annual health checks provided by the Chinese National Basic Public Health Service project after January 2020 will be enrolled. In addition to the data collected in the retrospective part, blood, urine and fecal samples and lifestyle questionnaires will be collected for further analysis. All participants will be followed-up till December 2025. A new prediction model for assessing cardiovascular disease risk will be established and evaluated.
Study Design
Outcome Measures
Primary Outcome Measures
- Major adverse cardiovascular events [5 years]
Major adverse cardiovascular events include all-cause mortality, acute myocardial infarction, coronary heart disease, heart failure and stroke.
Secondary Outcome Measures
- Atherosclerotic cardiovascular events [5 years]
Atherosclerotic cardiovascular events include acute myocardial infarction, coronary heart disease, heart failure and fatal and non-fatal stroke.
- All-cause mortality [5 years]
Defined as any death after enrollment.
- Cognitive dysfunction [5 years]
Defined as Montreal Cognitive Assessment (MoCA) Score < 26 points.
- Renal functional deterioration [5 years]
Evaluated through change in estimated glomerular filtration rate.
- Renal replacement therapy and/or death due to acute renal failure [5 years]
- Incident atrial fibrillation [5 years]
Atrial fibrillation is diagnosed according to the 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation.
Eligibility Criteria
Criteria
Inclusion Criteria:
- Meet at least one of the following conditions: 1. Age ≥ 65 years; 2. Diabetes mellitus; 3. Hypertension;
Exclusion Criteria:
- Refuse to provide informed consent;
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | The Fourth People's Hospital of Foshan | Foshan | Guangdong | China | 528041 |
| 2 | Nanfang Hospital, Southern Medical University | Guangzhou | Guangdong | China | 510515 |
Sponsors and Collaborators
- Nanfang Hospital of Southern Medical University
Investigators
- Principal Investigator: Jiancheng Xiu, MD, Nanfang Hospital of Southern Medical University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NFEC-2021-083