This is an Open-label, Single Arm Study to Evaluate the Safety and Tolerability of Treatment With CT0591CP in Patients With Relapsed and/or Refractory Multiple Myeloma.

Sponsor
The First Affiliated Hospital of Soochow University (Other)
Overall Status
Not yet recruiting
CT.gov ID
NCT05486975
Collaborator
(none)
18
29.7

Study Details

Study Description

Brief Summary

This is an open-label, single arm study to evaluate the safety and tolerability of treatment with CT0591CP in patients with relapsed and/or refractory multiple myeloma.

Condition or Disease Intervention/Treatment Phase
  • Biological: CT0591CP Cells
Early Phase 1

Study Design

Study Type:
Interventional
Anticipated Enrollment :
18 participants
Allocation:
N/A
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
Open Label, Single Arm Clinical Trial to Evaluate the Safety and Efficacy of CT0591CP Cell in Patients With Relapsed and/or Refractory Multiple Myeloma
Anticipated Study Start Date :
Aug 10, 2022
Anticipated Primary Completion Date :
Jan 29, 2025
Anticipated Study Completion Date :
Jan 29, 2025

Outcome Measures

Primary Outcome Measures

  1. Safety and tolerability [21-28 days post administration of CT0591CPcells]

    dose limiting toxicity

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 75 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  1. Patients and legally acceptable representative must have voluntarily signed ICF and willing to complete the study procedure, after fully understanding of the study.

  2. Age ≥ 18 years and ≤ 75 years, male or female.

  3. The patients have received at least 3 prior regimens for MM.

  4. Subjects should have received treatment with at least one proteasome inhibitor and one immunomodulatory drug (IMiD; and have been stable disease, relapsed or progressed after treatment with at least one regimen consisting of above-mentioned medications.

  5. Subjects should have relapsed within 12 months after the last line of therapy, or not achieved at least minimal response (MR) or disease has progressed within 60 days after last line of therapy, with documented evidence.

  6. Subjects should have measurable disease per IMWG 2016 criteria serum M-protein or urine M-protein are not measurable.

1) Serum M protein ≥ 5 g / L; 2) 24-hour urinary M-protein ≥ 200 mg; 3) The serum free light chain (sFLC) ratio was abnormal and the involved FLC ≥ 100mg/L in patients with light chain multiple myeloma whose serum or urinary M protein levels did not meet the assessable criteria.

  1. Expected survival > 12 weeks. 8. Eastern Cooperative Oncology Group (ECOG) scores 0 - 1.

  2. Subjects should have adequate function in hemostatic and liver and kidney. 10. Women of childbearing age must undergo a serum pregnancy test with negative results at screening and before lymphodepletion and be willing to use an effective and reliable method of contraception for at least 1 year after T cell infusion. All female subjects are prohibited from egg donation within 1 year after T cell infusion.

  3. Men must be willing to use an effective and reliable method of contraception for at least 1 year after T cell infusion if they have sexual activity with women of childbearing potential. All male subjects are prohibited from sperm donation within 1 year after T cell infusion.

Exclusion Criteria:
  1. Pregnant or lactating women.

  2. Subjects positive for any following tests: human immunodeficiency virus (HIV) antibody, Treponema pallidum (syphilis) antibody, hepatitis C virus (HCV) antibody,

  3. Active hepatitis B; HBV-DNA test must be below the lower limit of measurement.

  4. Subjects with any uncontrolled active infection (Except for prophylactic treatment).

  5. Subjects with AEs from previous treatment that have not recovered to Common Terminology Criteria for Adverse Events (CTCAE) v5.0 ≤ 1, excluding hair loss and other events that the treating physician considers as tolerable.

  6. Subjects who have received autologous BCMA CAR-T therapy

  7. Subjects who have had anti-BCMA therapy.

  8. Subjects who have received allogeneic stem cell transplantation for MM.

  9. Subjects who have received autologous stem cell transplantation less than 12 weeks before ICF.

  10. Positive anti-HLA-II antibody specificity test

  11. Subjects who have received any anti-MM treatment 14 days before ICF; the subjects are eligible to participate in the study regardless of the radiotherapy end date if the radiation area less than 5% of whole body.

  12. Subjects who have received systemic glucocorticoids within 7 days before infusion, except inhaled steroids.

  13. Subjects who have Waldenström macroglobulinemia, POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome or primary light chain amyloidosis.

  14. Subjects who have been received live attenuated vaccine within 8 weeks or inactivated vaccine within 4 weeks before lymphodepletion.

  15. Subjects allergic to or intolerant of fludarabine, cyclophosphamide, tocilizumab, or allergic to the ingredients (DMSO) of CT0591CP cell preparations; subject with confirmed another serious allergy history.

  16. Subjects who have any uncontrolled disease conditions within 6 months prior to the signing of inform consent.

  17. LVEF < 50%

  18. Blood oxygen saturation that can only be maintained at > 95% by oxygen inhalation.

  19. Subjects known to have active autoimmune diseases including but not limited to psoriasis, rheumatoid arthritis and other conditions that require long-term immunosuppressive therapy.

  20. Subjects with second malignancies in addition to MM are not eligible if the second malignancy has required treatment within the past 5 years

  21. Subjects who have central nervous system (CNS) metastases or symptomatic CNS involvement.

  22. Subjects who are unable or unwilling to comply with the requirements of clinical trial or other reasons that are not suitable for participating in the clinical trial.

  23. Subjects who have received major surgery 2 weeks prior to ICF or plan to receive major surgery within 4 weeks after cell infusion (excluding cataract and other local anesthesia).

  24. Subjects who are related to investigator or study personnel, or with possible conflict of interest with the investigator or study personnel.

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

  • The First Affiliated Hospital of Soochow University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
The First Affiliated Hospital of Soochow University
ClinicalTrials.gov Identifier:
NCT05486975
Other Study ID Numbers:
  • CT0591CP-CG6018
First Posted:
Aug 4, 2022
Last Update Posted:
Aug 4, 2022
Last Verified:
Aug 1, 2022
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of Aug 4, 2022