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The Relationship Between Driving Pressure, Mechanical Power, Oxygenation and Saturation Indices: Retrospective Observational Study

Sponsor
Bakirkoy Dr. Sadi Konuk Research and Training Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT05677165
Collaborator
(none)
361
Enrollment
1
Location
20.4
Actual Duration (Months)
17.7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

By using Mechanical Power and Driving Pressure instead of Pmean we calculate new oxygen saturation indices like Driving Pressure Oxygen Index (OIDP), Dynamic Power Oxygen Index (OIMPdyn), Total Power Oxygen Index (OIMPtot), Driving Pressure Saturation Index (OSIDP), Dynamic Power Saturation Index (OSIMPdyn) ve Power Saturation Index (OSIMPtot).

New oxygenation and saturation indices are able to predict ICU mortality better than the conventional indexes and rates.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    361 participants
    Observational Model:
    Other
    Time Perspective:
    Retrospective
    Official Title:
    The Relationship Between Driving Pressure, Mechanical Power, Oxygenation and Saturation Indices: Retrospective Observational Study
    Actual Study Start Date :
    Mar 18, 2020
    Actual Primary Completion Date :
    Nov 1, 2021
    Actual Study Completion Date :
    Nov 28, 2021

    Outcome Measures

    Primary Outcome Measures

    1. In hospital mortality [28 days]

      we estimate hospital mortality mortality by calculating new oxygenation index

    Secondary Outcome Measures

    1. Mechanical ventilatory free days [30 days]

      we estimate hospital mortality mortality by calculating new saturation index

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • Patients with a diagnosis of Covid-19 related Acute Respiratory Syndrome (C-ARDS) which hospitalized in Bakirköy Dr. Sadi Konuk Training and Research Hospital intensive care unit
    Exclusion Criteria:

    • Patients who did not receive invasive mechanical ventilation support.

    • Patients who stayed in the intensive care unit for less than 24 hours.

    • Patients with missing data

    • Patients who received mechanical ventilation support for less than 24 hours

    • Patients with Chronic Obstructive Pulmonary Disease (COPD).

    • Patients with congestive heart failure

    • Patients who underwent tube thoracostomy due to tension pneumothorax

    • Patients who received Extracorporeal Membrane Oxygenation (ECMO) support

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Bakirköy Dr sadi konuk Education hospital Istanbul Turkey

    Sponsors and Collaborators

    • Bakirkoy Dr. Sadi Konuk Research and Training Hospital

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Bakirkoy Dr. Sadi Konuk Research and Training Hospital
    ClinicalTrials.gov Identifier:
    NCT05677165
    Other Study ID Numbers:
    • 2021/293
    First Posted:
    Jan 10, 2023
    Last Update Posted:
    Jan 10, 2023
    Last Verified:
    Dec 1, 2022
    Individual Participant Data (IPD) Sharing Statement:
    Undecided
    Plan to Share IPD:
    Undecided
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by Bakirkoy Dr. Sadi Konuk Research and Training Hospital
    acute respiratory distress syndrome
    pneumonia
    oxygenation index
    saturation index
    Additional relevant MeSH terms:
    Pneumonia
    Respiratory Distress Syndrome
    Respiratory Distress Syndrome, Newborn
    Acute Lung Injury

    Study Results

    No Results Posted as of Jan 10, 2023