The Relationship Between Vitamin D Levels, Inflammatory Parameters and Disease Severity of COVID-19 Infection
Study Details
Study Description
Brief Summary
Vitamin D deficiency increases the susceptibility to respiratory virus infections and the severity of infections. Inflammation plays a key role in pathogenesis in COVID19 while identifying clinical course and prognosis COVID19.The aim of this study was to determine the relationship between 25OH vitamin D levels, inflammatory laboratory parameters of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), C-reactive protein (CRP) levels and disease severity of COVID19 infection.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
In this retrospective study 300 patients diagnosed with COVID19 were included. According to clinical classification of cases with COVID19 the patients were divided into three groups; mild (Group1), moderate (Group2) and severe/critical (Group3). The 25OH vitamin D values below 20 ng/ml were defined as deficiency, 21-29 ng/ml were defined as insufficiency, and 30 ng/ml and above were defined as normal. Patients' age, gender, comorbid diseases and laboratory values were recorded
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: Mild Clinical Group patients showing mild clinical symptoms without pneumonia. |
Diagnostic Test: Inflammatory Parameters
Laboratory measurement of patient's inflammatory status in unit of % and mg/dl
Other: 25 OH Vitamin D Level
Laboratory measurement of patient's 25 OH vitamin D level in unit of ng/dl
|
Experimental: Moderate Clinical Group patients with fever, other respiratory symptoms, and pneumonia findings based on radiological imaging |
Diagnostic Test: Inflammatory Parameters
Laboratory measurement of patient's inflammatory status in unit of % and mg/dl
Other: 25 OH Vitamin D Level
Laboratory measurement of patient's 25 OH vitamin D level in unit of ng/dl
|
Experimental: severe/critical clinical group severe one of these as follows; patients with hypoxia (≤93% oxygen saturation), respiratory distress (RR >30 times per minute), partial pressure of arterial blood oxygen (PaO 2 )/the fraction of inspired oxygen (FiO 2 ) ≤ 300 mmHg, patients whose chest imaging shows that lung damage develops significantly within 24 to 48 hours, or critical one of these as follows; respiratory failure requiring mechanical ventilation, signs of septic shock with multiple organ failure requiring intensive care unit admission. |
Diagnostic Test: Inflammatory Parameters
Laboratory measurement of patient's inflammatory status in unit of % and mg/dl
Other: 25 OH Vitamin D Level
Laboratory measurement of patient's 25 OH vitamin D level in unit of ng/dl
|
Outcome Measures
Primary Outcome Measures
- 25-OH vitamin D [1 day]
laboratory measurement in unit of ng/ml
- White blood cell count [1 day]
laboratory measurement in unit of x103/uL
- neutrophil count [1 day]
laboratory measurement in unit of x103/uL
- neutrophil ratio [1 day]
laboratory measurement in unit of %
- lymphocyte count [1 day]
x103/uL
- lymphocyte ratio [1 day]
laboratory measurement in unit of %
- platelet count [1 day]
laboratory measurement in unit of x103/uL
- hemoglobin count [1 day]
laboratory measurement in unit of g/dl
- C-reactive protein levels [1 day]
laboratory measurement in unit of mg/dL
- neutrophil to lymphocyte ratio [1 day]
laboratory measurement in unit of %
- platelet to lymphocyte ratio [1 day]
laboratory measurement in unit of %
Eligibility Criteria
Criteria
Inclusion Criteria:
- The study included 300 polymerase chain reaction (PCR) test positive patients and whose 25-OH vitamin D levels were measured in the last 6 months
Exclusion Criteria:
- Patients with COVID-19 whose 25-OH vitamin D levels were not measured in the last 6 months before the COVID-19 diagnosis were excluded from the study
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Gulcan Ozturk | Istanbul | Turkey | 34752 |
Sponsors and Collaborators
- Fatih Sultan Mehmet Training and Research Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Ali N. Elevated level of C-reactive protein may be an early marker to predict risk for severity of COVID-19. J Med Virol. 2020 Nov;92(11):2409-2411. doi: 10.1002/jmv.26097. Epub 2020 Jun 9.
- Ali N. Role of vitamin D in preventing of COVID-19 infection, progression and severity. J Infect Public Health. 2020 Oct;13(10):1373-1380. doi: 10.1016/j.jiph.2020.06.021. Epub 2020 Jun 20. Review.
- Khemka A, Suri A, Singh NK, Bansal SK. Role of Vitamin D Supplementation in Prevention and Treatment of COVID-19. Indian J Clin Biochem. 2020 Oct;35(4):502-503. doi: 10.1007/s12291-020-00908-3. Epub 2020 Jul 30.
- Gulcanozturk