THE RELATIONSHIP OF CRP/ALBUMIN RATIO LEVEL AND PROGNOSIS IN PREGNANT COVID-19 PATIENTS

• Sponsor: Adiyaman University Research Hospital (Other)
• Overall Status: Active, not recruiting
• CT.gov ID: NCT05242172
• Collaborator: (none)
• Enrollment: 127
• Location: 1
• Anticipated Duration (Months): 1.4
• Patients Per Site Per Month: 87.9

Study Details

Study Description

Brief Summary

The CRP/albumin ratio (CAR) is a recently defined parameter which represents the ratio of a positive acute phase reactant to a negative acute phase reactant. Recent studies have shown that the CRP/albumin ratio is a biomarker with prognostic value for various inflammatory disorders and serious diseases. With this study it is aimed to investigate the effect of CRP/albumin ratio in predicting the severity and prognosis of the disease in pregnant patients with more severe Covid-19 infection.

Condition or Disease	Intervention/Treatment	Phase
Corona Virus Infection; Pregnancy; Infection	Diagnostic Test: CRP/Albumin ratio

Detailed Description

Pregnant women are more susceptible to viral infections affecting the respiratory tract than non-pregnant women. Similar to non-pregnant patients, Covid-19 infection occurs with non-specific symptoms in pregnant patients. A computed tomography (CT) scan of lungs and several laboratory parameters are used to predict the prognosis of this infection, which starts with non-specific findings. Although it has been demonstrated that low-dose lung CT can be used safely in pregnant women, both clinicians and pregnant women tend to avoid tomography imaging due to its teratogenic effects

The CRP/albumin ratio (CAR) is a recently defined parameter which represents the ratio of a positive acute phase reactant to a negative acute phase reactant. It is an indicator of both the inflammatory state and the nutritional state, simultaneously. Recent studies have shown that the CRP/albumin ratio is a biomarker with prognostic value for various inflammatory disorders and serious diseases. With this study it is aimed to investigate the effect of CRP/albumin ratio in predicting the severity and prognosis of the disease in pregnant patients with more severe Covid-19 infection.

Study Design

• Study Type: Observational
• Actual Enrollment: 127 participants
• Observational Model: Cohort
• Time Perspective: Retrospective
• Official Title: THE RELATIONSHIP OF CRP/ALBUMIN RATIO LEVEL AND PROGNOSIS IN PREGNANT COVID-19 PATIENTS
• Actual Study Start Date: Jan 15, 2022
• Actual Primary Completion Date: Feb 15, 2022
• Anticipated Study Completion Date: Feb 28, 2022

Outcome Measures

Primary Outcome Measures

1. CRP/Albumin ratio [First day of hospital stay]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 65 Years
• Sexes Eligible for Study: Female

Inclusion Criteria:

• Covid PCR test positive patients

• Pregnant

Exclusion Criteria:

• Covid PCR test negative

• Missed data

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Adıyaman Training and Research Hospital	Adıyaman		Turkey	02200

Sponsors and Collaborators

• Adiyaman University Research Hospital

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Nezir Yılmaz, Principal investigator, Adiyaman University Research Hospital
• ClinicalTrials.gov Identifier: NCT05242172
• Other Study ID Numbers: 14/12/2021-2021/10-19
• First Posted: Feb 16, 2022
• Last Update Posted: Feb 16, 2022
• Last Verified: Jan 1, 2022

• Individual Participant Data (IPD) Sharing Statement: No
• Plan to Share IPD: No
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Infections; Communicable Diseases; Coronavirus Infections; Pregnancy Complications, Infectious

Study Results

No Results Posted as of Feb 16, 2022