Relationship of Retinal and Visual Cortex Structure and Visual Acuity After Congenital Cataract Surgery
Study Details
Study Description
Brief Summary
To evaluate the influence of the visual acuity after congenital surgery on the retinal and visual cortex structure.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
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Detailed Description
According to the visual acuity after congenital cataract surgery, 30 patients are divided into 3 groups.SD-OCT and MRI were used to measure the parameters of the retina and the visual cortex, to compare the differences between different groups, and to analyze the relationship between the structure of the retina and the visual cortex and visual acuity.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Group 1 The BCVA of eyes is greater than 0.6 |
|
| Group 2 The BCVA of eyes is from 0.1 to 0.6 |
|
| Group 3 The BCVA of eyes is less than 0.6 |
Outcome Measures
Primary Outcome Measures
- Macular thickness [2021.12.30]
Scan the 3.0mm diameter ETDRS ring area in the macular area with SD-OCT.
- Subfoveal choroidal thickness [2021.12.30]
Scan the Subfoveal choroid in enhanced scan mode with SD-OCT.
- Retinal nerve fiber layer thickness [2021.12.30]
Scan concentric circles with a length of 3.4mm and a diameter ranging from 2.5mm to 4.0mm in 12 directions centered on the optic disc with SD-OCT.
- The volume of the lateral geniculate body [2021.12.30]
Measure the volume of the lateral geniculate body by T1 phase scan of MRI
- The volume of the brodmann 17,18,19 area [2021.12.30]
Masure the volume of the brodmann 17,18,19 area by T1 phase scan of MRI
- The FA of the white matter fiber bundle [2021.12.30]
Measure the Fraction Anisotropy of the white matter fiber bundle related to visual signal transduction by DWI scan of MRI
Eligibility Criteria
Criteria
Inclusion Criteria:
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age of 4-60 years
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Congenital cataract surgery is planned
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The operation was successful without any complications
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Can cooperate well with OCT and MRI examinations
Exclusion Criteria:
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Intraoperative and postoperative complications include glaucoma, retinal, corneal, or refractive medium diseases
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Behavioral, cognitive impairment
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Developmental delay
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Eye Hospital of Wenzhou Medical College | Wenzhou | Zhejiang | China |
Sponsors and Collaborators
- Wenzhou Medical University
Investigators
- Study Director: Yune Zhao, Ophthalmology and Optometry Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
- Allen B, Schmitt MA, Kushner BJ, Rokers B. Retinothalamic White Matter Abnormalities in Amblyopia. Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):921-929. doi: 10.1167/iovs.17-22930.
- Long E, Zhang X, Liu Z, Wu X, Tan X, Lin D, Cao Q, Chen J, Lin Z, Wang D, Li X, Li J, Wang J, Li W, Lin H, Chen W, Liu Y. Dynamic response to initial stage blindness in visual system development. Clin Sci (Lond). 2017 Jun 28;131(13):1515-1527. doi: 10.1042/CS20170234. Print 2017 Jul 1.
- Lu L, Li Q, Zhang L, Tang S, Yang X, Liu L, Sweeney JA, Gong Q, Huang X. Altered cortical morphology of visual cortex in adults with monocular amblyopia. J Magn Reson Imaging. 2019 Nov;50(5):1405-1412. doi: 10.1002/jmri.26708. Epub 2019 Mar 10.
- amblyopia-LZL