Efficacy of Tranexamic Acid on Blood Loss During Percutaneous Nephrolithotomy.
Study Details
Study Description
Brief Summary
Efficacy of tranexamic acid on blood loss during percutaneous nephrolithotomy. a double-blind, placebo-controlled randomized clinical trial.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Detailed Description
To evaluate whether intravenous tranexamic acid or tranexamic acid in the irrigation fluid in percutaneous nephrolithotomy (PCNL) in reducing bleeding during and after PCNL.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Active Comparator: tranexamic acid local tranexamic acid inside the irrigation fluid |
Drug: Tranexamic acid injection
hemostatics use
Other Names:
|
Active Comparator: tranexamic acid IV tranexamic acid injection |
Drug: Tranexamic acid injection
hemostatics use
Other Names:
|
Outcome Measures
Primary Outcome Measures
- To assess the value of tranexamic acid [12 months]
To compare the efficacy and safety of 0.1% IV tranexamic acid versus inside the irrigant fluid tranexamic acid in reducing blood loss during PCNL. Moreover, to assess the adverse events of tranexamic acid.
Secondary Outcome Measures
- Hemoglobin drop post PCNL. [12 months]
Assess fall percentage in hemoglobin drop.
- Requirement of blood transfusion post PCNL. [12 months]
assess the total blood loss and requirement of blood transfusion post PCNL.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patient 18 years or older
-
Stones ≥ 2 cm and/or mild to moderate hydronephrosis.
Exclusion Criteria:
-
Age <18 years or Pregnancy
-
Bilateral simultaneous PCNL
-
Morbid obesity (BMI >40)
-
Refuse to complete study requirements
-
Untreated UTI
-
Atypical bowel interposition by CT
-
Tumour in the presumptive access tract area or Potential malignant kidney tumour
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Kafrelsheikh faculty of medicine | Kafr Ash Shaykh | Kafrelsheikh | Egypt |
Sponsors and Collaborators
- Kafrelsheikh University
Investigators
- Principal Investigator: Diaa Eldin Taha, MD, Lecturer of urology
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- RS/19.22