Retinal Vascular Reactivity in Subjects With Newly Diagnosed Glaucoma Before and After Selective Laser Trabeculoplasty
Study Details
Study Description
Brief Summary
The purpose of this study is to assess retinal blood flow and vascular reactivity in patients with newly diagnosed primary open angle glaucoma pre- and post-primary Selective Laser Trabeculoplasty(SLT). Canon Laser Blood Flowmeter will be used for the assessment of retinal blood flow.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
We previously found that vascular reactivity improved after short term treatment with dorzolamide drops. It is not clear whether this improvement was a direct effect of the medication or secondary effect of the decrease in IOP. We would like to see the change of vascular reactivity before and after SLT, which will decrease the intraocular pressure without pharmacologic effect.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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untreated glaucoma patients We will evaluate the blood flow before and after Selective Laser Trabeculoplasty in patients with primary open angel glaucoma. |
Procedure: Selective Laser Trabeculoplasty
Patient will have selective laser trabeculoplasty as the first treatment for glaucoma. This treatment will be dictated clinically, since we do not assign the interventions.
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Outcome Measures
Primary Outcome Measures
- blood flow [before and two-week after SLT]
The Canon Laser Blood Flowmetry will be used to assess the retinal blood flow.
Secondary Outcome Measures
- Intraocuclar pressure [before and two-week after SLT]
Intraocular pressure (IOP) will be measured by Goldmann applanation tonometry.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age 40-75 years (Male or Female)
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Best corrected visual acuity of at least 20/40
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No previous treatment for glaucoma
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Ametropia less than ±6.0 DS and ±2.5 DC)
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Non-smoker
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No cardiovascular/respiratory disorders
Exclusion Criteria:
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Past history of diabetes and cerebrovascular accident
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Vascular occlusive disease affecting the ocular circulation such as: diabetic retinopathy, retinal vein occlusion and retinal artery occlusion
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Previous intraocular surgery
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Ocular media opacities limiting the use of the imaging tests
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Toronto Western Hospital | Toronto | Ontario | Canada | M5T2S8 |
Sponsors and Collaborators
- University of Toronto
- University of Western Ontario, Canada
Investigators
- Principal Investigator: Chris Hudson, PhD, University of Toronto
Study Documents (Full-Text)
None provided.More Information
Publications
- SLT-blood flow study