Retinal Vascular Reactivity in Subjects With Newly Diagnosed Glaucoma Before and After Selective Laser Trabeculoplasty

Sponsor
University of Toronto (Other)
Overall Status
Unknown status
CT.gov ID
NCT01209975
Collaborator
University of Western Ontario, Canada (Other)
12
1

Study Details

Study Description

Brief Summary

The purpose of this study is to assess retinal blood flow and vascular reactivity in patients with newly diagnosed primary open angle glaucoma pre- and post-primary Selective Laser Trabeculoplasty(SLT). Canon Laser Blood Flowmeter will be used for the assessment of retinal blood flow.

Condition or Disease Intervention/Treatment Phase
  • Procedure: Selective Laser Trabeculoplasty

Detailed Description

We previously found that vascular reactivity improved after short term treatment with dorzolamide drops. It is not clear whether this improvement was a direct effect of the medication or secondary effect of the decrease in IOP. We would like to see the change of vascular reactivity before and after SLT, which will decrease the intraocular pressure without pharmacologic effect.

Study Design

Study Type:
Observational
Anticipated Enrollment :
12 participants
Observational Model:
Case-Only
Time Perspective:
Prospective
Official Title:
Retinal Vascular Reactivity in Response to Isoxic Hypercapnia in Subjects With Newly Diagnosed Glaucoma
Study Start Date :
Nov 1, 2008
Anticipated Primary Completion Date :
Nov 1, 2011

Arms and Interventions

Arm Intervention/Treatment
untreated glaucoma patients

We will evaluate the blood flow before and after Selective Laser Trabeculoplasty in patients with primary open angel glaucoma.

Procedure: Selective Laser Trabeculoplasty
Patient will have selective laser trabeculoplasty as the first treatment for glaucoma. This treatment will be dictated clinically, since we do not assign the interventions.

Outcome Measures

Primary Outcome Measures

  1. blood flow [before and two-week after SLT]

    The Canon Laser Blood Flowmetry will be used to assess the retinal blood flow.

Secondary Outcome Measures

  1. Intraocuclar pressure [before and two-week after SLT]

    Intraocular pressure (IOP) will be measured by Goldmann applanation tonometry.

Eligibility Criteria

Criteria

Ages Eligible for Study:
40 Years to 75 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  1. Age 40-75 years (Male or Female)

  2. Best corrected visual acuity of at least 20/40

  3. No previous treatment for glaucoma

  4. Ametropia less than ±6.0 DS and ±2.5 DC)

  5. Non-smoker

  6. No cardiovascular/respiratory disorders

Exclusion Criteria:
  1. Past history of diabetes and cerebrovascular accident

  2. Vascular occlusive disease affecting the ocular circulation such as: diabetic retinopathy, retinal vein occlusion and retinal artery occlusion

  3. Previous intraocular surgery

  4. Ocular media opacities limiting the use of the imaging tests

Contacts and Locations

Locations

Site City State Country Postal Code
1 Toronto Western Hospital Toronto Ontario Canada M5T2S8

Sponsors and Collaborators

  • University of Toronto
  • University of Western Ontario, Canada

Investigators

  • Principal Investigator: Chris Hudson, PhD, University of Toronto

Study Documents (Full-Text)

None provided.

More Information

Publications

Responsible Party:
, ,
ClinicalTrials.gov Identifier:
NCT01209975
Other Study ID Numbers:
  • SLT-blood flow study
First Posted:
Sep 28, 2010
Last Update Posted:
Sep 28, 2010
Last Verified:
Sep 1, 2010
Keywords provided by , ,
Additional relevant MeSH terms:

Study Results

No Results Posted as of Sep 28, 2010