Role of the Sympathetic Nervous System in Rosacea
Study Details
Study Description
Brief Summary
Rosacea is a common skin disorder which causes facial redness and inflammation in about 16 million Americans, from an unknown cause. Many triggers of rosacea symptoms are stressors that affect the sympathetic ("fight or flight") portion of the nervous system, and a recent pilot study suggests there is sympathetic dysfunction in rosacea. This project will benefit patients, clinicians, and basic scientists by increasing our understanding of sympathetic nervous system involvement in rosacea symptoms in order to develop improved treatments for patients with rosacea.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: Autonomic responses to stressors Protocol 1: mental math and handgrip exercise. Protocol 2: systemic stressors and end-organ receptor stimulation. Protocol 3: local heating. |
Other: systemic and local stressors
Protocol 1: skin sympathetic nerve activity will be measured during mental math and handgrip exercise. Protocol 2: skin end organ responses will be measured at baseline and in response to systemic stressors and end-organ receptor stimulation. Protocol 3: skin end organ responses will be measured at baseline and during local heating.
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Outcome Measures
Primary Outcome Measures
- Skin blood flow [Immediate (during the single-day study). This study consists of a one-day protocol, during which this outcome is measured.]
laser Doppler flowmetry
- Skin sympathetic nerve activity [Immediate (during the single-day study). This study consists of a one-day protocol, during which this outcome is measured.]
microneurography
Eligibility Criteria
Criteria
Inclusion Criteria:
- Otherwise healthy males and non-pregnant/non-lactating females with mild to moderate erythematotelangiectactic rosacea, as well as age-sex matched healthy control subjects.
Exclusion Criteria:
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Neurological, cardiovascular, respiratory, metabolic, muscular, or other dermatological disorders
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Current history of alcohol and/or drug abuse
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Known allergies or hypersensitivities to medications/drugs that are used in the protocol
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Current smoking or regular smoking within the last 2 years
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Body mass index > 35 kg/m2
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Medications or supplements which are known to affect neural, cardiovascular, or muscular responses
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Indiana University | Indianapolis | Indiana | United States | 46202 |
Sponsors and Collaborators
- Indiana University
- Marian University
Investigators
- Principal Investigator: Kristen Metzler-Wilson, PT, PhD, Indiana University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 1R15AR069912-01A1