Investigation of the Relationship Between Salivary Histatine-5 Level and Vaginal Candidiasis in Women
Study Details
Study Description
Brief Summary
The low Histatine-5 (HST-5) level of the saliva can lead to vaginal candidiasis. Because HST-5 level in the saliva can effect vaginal Ph, flora and local defence mechanisms.
Histatine-5 is secreted in the parotis and submandibular glands. İt riches histidine amino ascid and have antifungal activity. Salivary proteins and their plasma levels were found as similar in the literature.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Women with regularly menstrual cycle will enroll in the study than will separate two groups:
Study group: women with vaginal candidiasis ( diagnosed by clinic and lab.)
Control group: women ( not have any vaginal infections candida and others)
Saliva samples will be taken from two groups than HST-5 level will be analyzed. Finally HST-5 levels of the two groups will be compared .
Women with diabetes, immun deficiency, pregnancy, virgin, menopausal period , premature ovarian failure will be excluded.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Case group vaginal candidiasis |
Other: salivary sample
salivary sample
|
| Control group healty women |
Other: salivary sample
salivary sample
|
Outcome Measures
Primary Outcome Measures
- SALIVARY HISTATINE-5 LEVEL IN THE WOMEN WITH VAGINAL CANDIDIASIS [1 month]
we done salivary protein electrophoresis( as a small sample group ; consist of vaginal candidiasis and control patients) and Hst5 protein band was seen
Secondary Outcome Measures
- SALIVARY HISTATINE-5 LEVEL IN THE WOMEN WITH VAGINAL CANDIDIASIS [2 month]
We found , low salivary Hst5 levels in women with vaginal candidiasis than control group (p=0.001)
Eligibility Criteria
Criteria
Inclusion Criteria: women with regularly menstrual cycle , diagnosed candidal vaginosis and not have any vaginal infection.
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Exclusion Criteria: diabetes, immun deficiency, menopause, premature ovarian failure, pregnancy, virgin
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Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | İrem Şenyuva | Usak | Turkey |
Sponsors and Collaborators
- Usak State Hospital
Investigators
- Principal Investigator: İREM ŞENYUVA, M.D, USAK TRAINING AND RESEARCH HOSPITAL
Study Documents (Full-Text)
None provided.More Information
Publications
- Khurshid Z, Najeeb S, Mali M, Moin SF, Raza SQ, Zohaib S, Sefat F, Zafar MS. Histatin peptides: Pharmacological functions and their applications in dentistry. Saudi Pharm J. 2017 Jan;25(1):25-31. doi: 10.1016/j.jsps.2016.04.027. Epub 2016 May 4. Review.
- Liao H, Liu S, Wang H, Su H, Liu Z. Efficacy of Histatin5 in a murine model of vulvovaginal candidiasis caused by Candida albicans. Pathog Dis. 2017 Aug 31;75(6). doi: 10.1093/femspd/ftx072.
- Loo JA, Yan W, Ramachandran P, Wong DT. Comparative human salivary and plasma proteomes. J Dent Res. 2010 Oct;89(10):1016-23. doi: 10.1177/0022034510380414. Epub 2010 Aug 25. Review.
- Usak State Hospital