SABO: Sarcopenia After Bariatric Surgery in Older Patients: A Cohort Study
The retrospective cohort study will compare the prevalence of sarcopenia and associated factors between older patients who have undergone bariatric surgery and older patients with obesity without previous bariatric surgery.
|Condition or Disease||Intervention/Treatment||Phase|
The aim of the study is to compare the prevalence of sarcopenia and nutritional status between adults older than 65 years who have previously undergone bariatric surgery and patients with obesity but without previous bariatric surgery. Current sarcopenia will be assessed during a cross-sectional assessment after surgery using the criteria from the European Working Group on Sarcopenia in Older People (EWGSOP).
Arms and Interventions
Cohort 1: Older patients with overweight, obesity after bariatric surgery
Procedure: Bariatric surgery
Cohort 2: Older patients with overweight, obesity without bariatric surgery
Primary Outcome Measures
- The number of older patients with sarcopenia after bariatric surgery compared to non-surgical control patients. [At least one year post surgery]
a) Sarcopenia will be classified according to the criteria form the European Working Group on Sarcopenia in Older People revised guidelines (EWGSOP2) based on skeletal muscle mass, muscle strength and physical performance criteria.
Secondary Outcome Measures
- 1. Appendicular skeletal muscle mass older of patients after bariatric surgery compared to non-surgical control patients [At least one year post surgery]
1. Appendicular skeletal muscle mass older of patients after bariatric surgery compared to non-surgical control patients
- 2. The prevalence of nutrient deficiencies in older patients after bariatric surgery compared to non-surgical control patients. [At least one year post surgery]
a. Indices of nutrient deficiencies will include reported dietary intake of protein, zinc, selenium, and blood levels of Vitamin D, zinc, and selenium.
- 3. Markers of chronic systemic inflammation in older patients after bariatric surgery compared to non-surgical control patients [At least one year post surgery]
Inflammatory markers will include CRP, IL-1β, IL-6, IL-8, TNF-α
Signed informed consent
Age 65 years or older
Cohort 1 (exposed): Previous bariatric surgery for obesity at least 1 one year ago
Cohort 2 (unexposed): No previous weight loss surgery
Current diagnosis of cancer
Advanced organ failure, including chronic kidney disease Stage 5, liver cirrhosis Stage 3, intestinal failure, heart failure stage D, or chronic obstructive pulmonary disease stage 4.
Neuromuscular degenerative conditions
Contacts and Locations
|1||Obesity Clinic University Hospitals Leuven||Leuven||Belgium||3000|
Sponsors and Collaborators
- Universitaire Ziekenhuizen KU Leuven
Study Documents (Full-Text)None provided.