SARS CoV-2 Infection and Inflammatory Biomarkers
Study Details
Study Description
Brief Summary
Early research suggests that inflammation plays a key role in the development of SARS CoV-2 infection. The immune response to respiratory infection is characterized by an influx of neutrophils to the lungs. This study ought to investigate the association of simple biomarkers such as NLR and PLR with the clinical outcome in SARS CoV-2 infection patients.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Early research suggests that inflammation plays a key role in the development of SARS CoV-2 infection. The immune response to respiratory infection is characterized by an influx of neutrophils to the lungs. Moreover, previous studies have demonstrated that a sustained release of anti-inflammatory cytokines may lead to high levels of circulating neutrophils and lymphocytes' apoptosis with subsequent lymphopenia and immune response imbalance. Therefore, circulating biomarkers that represent inflammation and immune status could serve as potential predictors for the prognosis of SARS CoV-2 patients. The neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are cheap and simply calculated biomarkers which have been identified as markers of systemic inflammation, severity of the disease and prognosis in several patient populations.
This study ought to investigate the association of simple biomarkers such as NLR and PLR with the clinical outcome in SARS CoV-2 infection patients.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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COVID-19 infection Consecutive patients with polymerase chain reaction (PCR) confirmed SARS CoV-2 infection |
Other: Simple inflammatory biomarkers measurement
In patients with polymerase chain reaction (PCR) confirmed SARS CoV-2 infection the values of simple inflammatory biomarkers such NLR will be measured
Other Names:
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Outcome Measures
Primary Outcome Measures
- Outcome [1 year]
Outcome after COVID-19 infection
Eligibility Criteria
Criteria
Inclusion Criteria:
- Consecutive patients with polymerase chain reaction (PCR) confirmed SARS CoV-2 infection
Exclusion Criteria:
- Patients aged<18 years
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Univeristy of Thessaly | Larissa | Thessaly | Greece | 41110 |
Sponsors and Collaborators
- University of Thessaly
Investigators
- Study Chair: Eleni Arnaoutoglou, M.D., Ph.D., Study Chair
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 46937