Spread-COVID: SARS-CoV-2 in Stools Compared to Respiratory Viral Strains.
Study Details
Study Description
Brief Summary
The aim of the study is to characterize and to quantify SARS-CoV-2 strains in stools, in comparison with the viral strains in respiratory samples, from patients hospitalized for COVID-19. The methods will be standard ddPCR quantifying SARS-CoV-2 RNA and next generation sequencing-whole genome sequencing. The expected results will allow us to better understand SARS-CoV-2 dynamics and compartmentalization, both in the respiratory tract and in digestive-related tissues, according to the evolution of SARS-CoV-2 variants.
Condition or Disease | Intervention/Treatment | Phase |
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Study Design
Outcome Measures
Primary Outcome Measures
- SARS-CoV-2 dynamics in stools. [30 monthes]
Evolutive SARS-CoV-2 dynamics in stools compared to respiratory tract: molecular quantification (ddPCR) of SARS-CoV-2 variants genome in stools, compared to the viral quantification in respiratory samples.
Secondary Outcome Measures
- SARS-CoV-2 in stools compared to the virus in wastewaters. [30 monthes]
SARS-CoV-2 in stools compared to wastewaters: molecular quantification (ddPCR) of SARS-CoV-2 variants genome in stools, compared to the viral quantification in wastewater samples.
- Modelization of SARS-CoV-2 load in stools and COVID-19 global frequency. [30 monthes]
SARS-CoV-2 load in stools and COVID-19 global frequency: correlation between SARS-CoV-2 load in stools by ddPCR and COVID-19 incidence in the neighboring global inhabitants population.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age: men or women of 18 years-old or more
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Clinical signs: hospitalised patient for SARS-CoV-2 infection, nasopharyngeal PCR-confirmed (or any other sample) (in: Infectious diseases department, Intensive care unit), whatever the severity of the clinical form.
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The subject gave his/her informed and writen consent, after complete explanations on the research schedule.
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Compulsory affiliation to a social security scheme.
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Previous medical examination, when a patient is admitted to the hospital, according to good clinical practices.
Exclusion Criteria:
- Subject corresponding to articles L. 1121-5, L. 1121-7 and L1121-8 of the French
Public health code:
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pregnant woman, parturient or breastfeeding woman
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Minor person
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Person of full age under guardianship, curatorship, safeguard of justice
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Woman who wants to be pregnant during the study period
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Person in psychiatric care - articles L. 3212-1 and L. 3213-1 who do not fall under the article L. 1121-8 (without consent hospitalisation)
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Schvoerer | Vandoeuvre Les Nancy | France | 54511 |
Sponsors and Collaborators
- Central Hospital, Nancy, France
Investigators
- Principal Investigator: Evelyne ES Schvoerer, Prof., University hospital Nancy, France
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2022-A00731-42