Memantine Effects on Sensorimotor Gating and Neurocognition in Schizophrenia
Study Details
Study Description
Brief Summary
This application seeks to determine if neurophysiological metrics of memantine (MEM)-enhanced early auditory information processing (EAIP) in schizophrenia (SZ) mediate gains in auditory processing fidelity (APF) and auditory learning.
Condition or Disease | Intervention/Treatment | Phase |
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Phase 4 |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Active Comparator: Memantine
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Drug: Memantine
To assess the acute effects of MEM (0 vs. 20 mg) on measures of auditory processing fidelity, auditory learning and EAIP, in AP-medicated adult SZ patients and HS.
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Placebo Comparator: Placebo
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Drug: Placebos
To assess the acute effects of MEM (0 vs. 20 mg) on measures of auditory processing fidelity, auditory learning and EAIP, in AP-medicated adult SZ patients and HS.
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Outcome Measures
Primary Outcome Measures
- prepulse inhibition (PPI) [7 and 14 days post baseline]
Change from placebo measure in PPI
- mismatch negativity (MMN) [7 and 14 days post baseline]
Change from placebo measure in MMN
- gamma auditory steady-state response (ASSR) [7 and 14 days post baseline]
Change from placebo measure in ASSR
Eligibility Criteria
Criteria
Inclusion Criteria:
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diagnosis of schizophrenia OR schizoaffective-depressed OR healthy subjects
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ages 18-50 for all subjects
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double barrier contraception for all subjects
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not pregnant for all subjects
Exclusion Criteria:
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DSM-IV Axis I or II Diagnosis for for healthy subjects
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MEM or amantadine for patients
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current substance abuse for all subjects
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current recreational drug use for all subjects
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history of other significant medical illness (e.g. cancer, diabetes, heart disease, HIV, seizures) for all subjects
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open head injury or closed head injury with loss of consciousness > 1 min for all subjects
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hearing or visual impairment for all subjects
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pregnancy for all subjects
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dementia for all subjects
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mental retardation for all subjects
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Clinical Teaching Facility (CTF-B102) at UCSD Medical Center | San Diego | California | United States | 92103 |
Sponsors and Collaborators
- University of California, San Diego
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- R01MH094320