Exercise, Cognitive Function and Neuroplasticity in Healthy Adults
Study Details
Study Description
Brief Summary
The overall goal of the proposed study is to compare the effects of 4 weeks of moderate or high intensity aerobic exercise on neuroplasticity, cognitive performance and gait and postural control in sedentary healthy adults.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Detailed Description
The primary aim of the study is to compare the effects of a moderate intensity aerobic exercise intervention (delivered at 55-64% age-predicted maximal heart rate) with a high intensity aerobic exercise intervention (delivered at 65%-90% age-predicted maximal heart rate) on measures that probe cortical synaptic plasticity using transcranial magnetic stimulation (TMS) in sedentary healthy adults.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Active Comparator: Moderate intensity exercise. Moderate intensity aerobic exercise intervention (delivered at 55-64% age-predicted maximal heart rate), 4 times per week for 4 weeks. |
Behavioral: Moderate intensity exercise.
Moderate intensity aerobic exercise intervention (delivered at 55-64% age-predicted maximal heart rate), 4 times per week for 4 weeks.
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Experimental: High intensity exercise High intensity aerobic exercise intervention (delivered at 65%-90% age-predicted maximal heart rate), 4 times per week for 4 weeks. |
Behavioral: High intensity exercise.
High intensity aerobic exercise intervention (delivered at 65-90% age-predicted maximal heart rate), 4 times per week for 4 weeks.
|
Outcome Measures
Primary Outcome Measures
- Change in cortical synaptic plasticity using transcranial magnetic stimulation (TMS) from baseline to post-exercise. [Baseline, 4 weeks]
Plasticity with TMS
Eligibility Criteria
Criteria
Inclusion Criteria:
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Adult males and females aged 18-70 years old
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Primary language is English
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Sedentary (defined as not engaging in purposeful physical activity more than 2 times over the last two months)
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Exercise clearance
Exclusion Criteria:
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Presence of cognitive, neurologic or orthopedic conditions that could affect performance of the testing and training procedures
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History of migraines.
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History of fainting spells of unknown or undetermined etiology that might constitute seizures
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History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or family history of treatment resistant epilepsy
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Any current history of a psychiatric illness
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Any unstable medical condition
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No medication is an absolute exclusion from TMS. Medications will be reviewed by the Principal Investigator and a decision about inclusion will be made based on the following:
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The subject's past medical history, drug dose, history of recent medication changes or duration of treatment, and combination with other CNS active drugs.
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The published TMS guidelines review medications to be considered with TMS (Rossi, Hallett, Rossini, Pascual-Leone, & Safety of TMS Consensus Group, 2009).
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Any metal in the brain, skull or elsewhere unless approved by the responsible MD
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Any medical devices (i.e. Cardiac pacemaker, deep brain stimulator, medication infusion pump, cochlear implant, vagal nerve stimulator)
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Intracranial lesion
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Substance abuse or dependence within the past six months Subjects who, in the Investigator's opinion, might not be suitable for the study
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | University of Miami Miller School of Medicine | Miami | Florida | United States | 33136 |
Sponsors and Collaborators
- University of Miami
Investigators
- Principal Investigator: Joyce R Gomes Osman, PT, PhD, University of Miami
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 20161059