Segmentation of Structural Abnormalities in Chronic Lung Diseases
Study Details
Study Description
Brief Summary
Lung structural abnormalities are complex, time-consuming, and may lack reproducibility to evaluate visually on CT scans. The study's aim is to perform automated recognition of structural abnormalities in CT scans of patients with chronic lung diseases by using dedicated software.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Three chronic lung diseases will constitute the target of the study, by using retrospective data from each lung disease:
-
Cystic fibrosis
-
Asthma and COPD
-
Interstitial lung diseases
Dedicated algorithms will be developped for each disease condition.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Train dataset This group is dedicated to developing an automated algorithm |
Other: Observational study
|
| Test dataset This group is dedicated to testing the performance of an automated algorithm |
Other: Observational study
|
| Clinical Validation This group is dedicated to assessing the clinical validity of the measurement in an independent validation cohort |
Other: Observational study
|
Outcome Measures
Primary Outcome Measures
- Validity of automated measurement [From date of inclusion until the date of final quantification, assessed up to 12 months]
Correlations and comparisons with other biomarker of the disease severity
Secondary Outcome Measures
- Correlation with pulmonary function test [From date of inclusion until the date of final quantification, assessed up to 12 months]
Correlation of quantitative measurement with pulmonary function
- Longitudinal variation over time [From date of inclusion until the date of final quantification, assessed up to 12 months]
Comparison of quantitative measurement at two time points
- Reproducibility [From date of inclusion until the date of final quantification, assessed up to 12 months]
Evaluation of measurements when performed twice
Eligibility Criteria
Criteria
Inclusion Criteria:
- Patients with chronic lung disease and clinical examination, pulmonary function test, and CT acquired during a routine follow-up
Exclusion Criteria:
- In the Clinical Validation group, patients with exacerbation or part of the other groups
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Hopital Haut Leveque | Pessac | France |
Sponsors and Collaborators
- Hôpital Haut Lévêque
- Centre National de la Recherche Scientifique, France
- Institut National de la Santé Et de la Recherche Médicale, France
- University of Cincinnati
Investigators
- Study Chair: Francois Laurent, Pr, Hopital Haut Leveque
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- SA-AI