Semitendinosus Graft as Meniscal Transplant
Study Details
Study Description
Brief Summary
Removal of meniscal tissue is described to result in poor knee function and a significant risk for future development of osteoarthritis. Different implants have been suggested to substitute a removed meniscus. Meniscal allograft transplantation is not widely available due to costs and availability. The semitendinosus tendon is a known graft with biological properties with potential to remodel and revascularize in an intraarticular environment such as anterior cruciate ligament reconstruction. The objective for this study was to investigate whether the semitendinosus tendon graft could function as a meniscal transplant.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Outcome Measures
Primary Outcome Measures
- Failure [2 years]
Surgical failure of transplant defined as meniscus symptoms (joint line tenderness, swelling, locking or positive McMurray) resulting in a need for re-arthroscopy and subtotal or total resection of the transplant.
Secondary Outcome Measures
- Improved subjective knee function [2 years]
Patient reported outcome measure using the Knee Injury and Osteoarthritis Outcome Score (KOOS), 0-100 where 100 indicate best possible result.
- Improved subjective knee function [2 years]
Patient reported outcome measure using Lysholm (0-100 where 100 indicate best possible result) and Tegner activity score (0-10, where 10 indicate the highest activity level) .
- Improved subjective knee function [2 years]
Patient reported outcome measure using Euroqol 5 dimensions (EQ-5D) score (quality of life instrument with five dimensions with points from 1 to 3 where 1 indicates no problem and 3 indicate severe problems).
- Improved subjective knee function [2 years]
Patient reported outcome measure using Global score (0-10 where 10 indicate best possible result)
Eligibility Criteria
Criteria
Inclusion Criteria:
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Previous subtotal or total meniscectomy
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Post meniscectomy symptoms
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No osteoarthritic changes on radiography more than Ahlbäck 1
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Knee aligment (hip-knee-angle) +/- 3°
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No persisting ACL insufficiency
Exclusion Criteria:
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Difficulty understanding the instructions
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Current psychiatric diagnosis
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Smoking
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | KISÖS | Stockholm | Sweden | 11883 |
Sponsors and Collaborators
- Karolinska Institutet
Investigators
None specified.Study Documents (Full-Text)
More Information
Publications
- Ayala Mejias JD, Sciamanna RC, Muniesa MP, Pérez-España LA. A case report of semitendinosus tendon autograft for reconstruction of the meniscal wall supporting a collagen implant. BMC Sports Sci Med Rehabil. 2013 Mar 28;5:4. doi: 10.1186/2052-1847-5-4.
- Johnson LL, Feagin JA Jr. Autogenous tendon graft substitution for absent knee joint meniscus: a pilot study. Arthroscopy. 2000 Mar;16(2):191-6.
- Kohn D. Autograft meniscus replacement: experimental and clinical results. Knee Surg Sports Traumatol Arthrosc. 1993;1(2):123-5.
- semiTmeniscus