Sepsis at Södersjukhuset-Adherence to Treatment Guidelines
Study Details
Study Description
Brief Summary
A retrospective single-center study with patients with suspected sepsis admitted to the Emergency Department at Södersjukhuset during a period of two years. The aim is to describe the association between adherence to treatment guidelines, gender, incidence and mortality for patients with sepsis.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
In this single-center study, patients with suspected sepsis admitted to the Emergency Department at Södersjukhuset during a period of two years will be included. About 11,000 patients will be included. Patient data including described sepsis symptoms will be drawn from the electronic medical record, TakeCare and Clinisoft. Logistic regression analysis will adjust for age, gender, comorbidity according to Charlson score, vital signs, with preliminary focus of infection (pneumonia, urinary tract infection, abdominal, other, unknown). The Surviving Sepsis guidelines for the time period are: 3-hour bundle including lactate measurement, obtaining blood culture, fluid treatment if hypotensive and administration of broad-spectrum antibiotics. The 6-hour bundles with administration of vasopressors if needed, remeasure lactate if elevated, with persistent hypotension re-asses volume status and tissue perfusion. Time zero is defined as the admission time to the emergency department. The aim is to describe the association between adherence to treatment guidelines, gender, incidence and mortality for patients with sepsis.
Study Design
Outcome Measures
Primary Outcome Measures
- Gender differences in 90-day mortality [90 days]
Gender differences in percentage of patients who died before day 90
Secondary Outcome Measures
- Association between adherence to treatment guidelines and mortality [90 days]
Association between number of completed sepsis bundles and mortality
- Incidence of sepsis [90 days]
Number of patients admitted to the Emergency Department at Södersjukhuset during the study period comparing to the hospitals catchment area
Eligibility Criteria
Criteria
Inclusion criteria:
• Patients admitted to the Emergency Department at Södersjukhuset with suspicion of sepsis defined as blood cultures taken and intravenous antibiotics of type beta-lactam or aminoglycoside prescribed within 48 hours of admission.
Exclusion criteria:
• Patients transferred from other hospitals or treatment clinics.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Södersjukhuset | Stockholm | Sweden | 11880 |
Sponsors and Collaborators
- Karolinska Institutet
Investigators
- Principal Investigator: Katarina Bohm, Ass Prof, Karolinska Institutet
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- SepsisSoS