Seroprevalence of Infection-induced SARS-CoV-2 Antibodies (COVID-19) in Children
Study Details
Study Description
Brief Summary
It is unknown what proportion of children have been exposed to SARS-CoV-2 and how many have antibodies among children seeking medical care for non-Covid-19 related conditions.
The aim of this study is to identify children with IgG antibodies to SARS-CoV-2 who have not been previously diagnosed and are presumed/confirmed Covid-19 negative, then determine the level of immunity in this population which could inform further decisions about covid-19 vaccine strategies for children
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Enrolled participants will have a survey about demographic information, history of previous suspected/confirmed Covid-19 infection or exposed to SARS-CoV-2, Covid-19 vaccination status. For participants aged less than 12 months, participants' mothers' status of Covid-19 vaccination and/or previous infection will be recorded. Participants will then complete serologic testing for SARS-CoV-2 IgG antibodies using residual plasma specimens collected/stored for routine laboratory tests on the date of enrollment. The study will characterize the prevalence of antibody positivity in this population and assess whether there is a correlation between demographic characteristics and antibodies levels.
Study Design
Outcome Measures
Primary Outcome Measures
- The percentage of children with IgG SARS-CoV-2 antibodies in Plasma [6 month]
The percentage of children with IgG SARS-CoV-2 antibodies to the total number of children enrolled in the study
- Immunoglobulins (G) to SARS-CoV-2 in plasma [6 month]
Mean antibody titres (IgG) to SARS-CoV-2 in plasma using SIEMENS assays
Secondary Outcome Measures
- Measure of association between SARS-CoV-2 IgG seropositivity and characteristics [6 month]
socio-demographics, previous exposure to SARS-CoV-2
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age ≤ 18 years old.
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Seeking medical care at Vietnam National Children's Hospital for any condition not related to acute Covid-19
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Have not been previously diagnosed and are presumed/confirmed COVID-19 negative
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Have blood specimens collected for any routine biochemistry test on the date enrollment
Exclusion Criteria:
- Refusal to participate in this study.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Vietnam National Children's Hospital | Hanoi | Vietnam |
Sponsors and Collaborators
- National Children's Hospital, Vietnam
Investigators
- Principal Investigator: Phuc H Phan, MD, Vietnam National Children's Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- ChildrensHVietnam