Sex-specific Differences in AAA Complexity
Study Details
Study Description
Brief Summary
A retrospective cohort study of computed tomography scans of AAA patients considered for repair, in order to identify sex specific differences in abdominal aortic aneurysm (AAA) metrics and the association between anatomical differences/features of complexity and adverse patient outcome.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
A retrospective cohort study of computed tomography scans of AAA patients considered for repair.
The study aims to, firstly, identify sex specific differences in abdominal aortic aneurysm (AAA) metrics utilising manual and automated image processing techniques; and secondly, if numbers are sufficient, explore the association between features of AAA complexity and adverse patient outcome.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Men Male participants |
Diagnostic Test: CTA Aorta
Computed Tomography Angiography - Aorta Whole
|
| Women Female Participants |
Diagnostic Test: CTA Aorta
Computed Tomography Angiography - Aorta Whole
|
Outcome Measures
Primary Outcome Measures
- Sex-specific differences in thrombus burden [Pre-operative CT]
Volumetric assessment of aortic thrombus
- Sex-specific differences in anatomical complexity [Pre-operative CT]
Anatomical as assessed by current IFU (instructions for use) criteria. (Anatomy within pre-specified vessel diameter, length, tortuosity and calcification criteria for insertion of endovascular stent graft for AAA repair.)
Secondary Outcome Measures
- Association between anatomical differences and adverse patient outcome for patients receiving operative repair - need for transfusion, risk of vessel injury, ischaemia (bowel or limb), renal injury and re-intervention/endoleak. [30 days]
Post-operative outcomes
Eligibility Criteria
Criteria
Inclusion Criteria:
-
All adult patients with AAA receiving assessment +/- primary open or endovascular repair at participating centre from 1/1/2010 to 31/12/2020.
-
Must have AAA >= 5cm.
-
Must have CT imaging within 1 year of operation or definitive turn down for treatment.
Exclusion Criteria:
-
Insufficient CT imaging quality (>3mm slices) or lack of CT within 1 year of operation.
-
Insufficient clinical data to establish risk factors or clinical outcomes.
-
Ruptured aneurysm, aorto-iliac occlusive disease, isolated iliac aneurysm, penetrating aortic ulcer, dissection, juxta or supra-renal aneurysm.
-
Secondary repair/not primary treatment decision for AAA repair.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Imperial College London | London | United Kingdom |
Sponsors and Collaborators
- Imperial College London
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 292985