Effect of Oral Collagen Tripeptide on Skin Moisture and Wrinkles in Adult Women

Sponsor
Pusan National University Yangsan Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT03505684
Collaborator
(none)
84
1
2
7.2
11.7

Study Details

Study Description

Brief Summary

Comparison of a randomized, double-blind, and control-group study for the effect of oral ingestion of collagen tripeptides derived from fish on dermal moistures and wrinkles body fat reduction in participants

Condition or Disease Intervention/Treatment Phase
  • Dietary Supplement: CTP
  • Dietary Supplement: placebo (starch)
N/A

Detailed Description

The aim is to investigate the effect of oral ingestion of collagen tripeptides derived from fish on dermal moistures and wrinkles body fat reduction in participants by a randomized, double-blind, and control-group study.

Study Design

Study Type:
Interventional
Actual Enrollment :
84 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Triple (Participant, Care Provider, Investigator)
Primary Purpose:
Supportive Care
Official Title:
Effect of Oral Collagen Tripeptide on Skin Moisture and Wrinkles in Adult Women
Actual Study Start Date :
Dec 24, 2017
Actual Primary Completion Date :
Jul 15, 2018
Actual Study Completion Date :
Jul 30, 2018

Arms and Interventions

Arm Intervention/Treatment
Experimental: CTP group

1,000 mg of collagen tripeptide (CTP) was orally administered per day for 12 weeks.

Dietary Supplement: CTP
1,000 mg of CTP was orally administered per day for 12 weeks.

Placebo Comparator: Control group

1,000 mg of placebo (starch) was orally administered per day for 12 weeks

Dietary Supplement: placebo (starch)
placebo (starch)

Outcome Measures

Primary Outcome Measures

  1. changes in Transepidermal Waterloss by Tewameter [baseline, after 6 weeks, and after 12 weeks]

    comparison between baseline, after 6 weeks, and after 12 weeks

Secondary Outcome Measures

  1. changes in skin wrinkling indices by Visiometer [baseline, after 6 weeks, and after 12 weeks]

    comparison between baseline, after 6 weeks, and after 12 weeks

  2. skin elasticity by Cutometer [baseline, after 6 weeks, and after 12 weeks]

    comparison between baseline, after 6 weeks, and after 12 weeks

  3. changes in hydration level of the skin surface by Corneometer [baseline, after 6 weeks, and after 12 weeks]

    comparison between baseline, after 6 weeks, and after 12 weeks

Eligibility Criteria

Criteria

Ages Eligible for Study:
40 Years to 60 Years
Sexes Eligible for Study:
Female
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • = 4 of Tewameter

Exclusion Criteria:
  • Within the last 6 months, took skin surgery including cosmetic purpose

  • Diabetic patients with poor glycemic control with a fasting blood glucose of 160 mg/dl or more

  • Creatinine levels: more than twice the normal upper limit

  • AST (GOT) or ALT (GPT) levels: more than twice the normal upper limit

  • Uncontrolled hypertension

  • sun allergy or sensitive skin

  • functional cosmetics that affect dermal moistures and wrinkles within the last 3 months.

  • If you have participated or are planning to participate in another clinical trial within the past month

  • Alcohol abuser

  • If they are pregnant or lactating or have a pregnancy plan during the clinical trial Those with allergic reactions to the constituent food

  • Any person deemed inappropriate by the researcher for other reasons

Contacts and Locations

Locations

Site City State Country Postal Code
1 Integrated Research Institute for Natural Ingredients and Functional Foods Yangsan Korea, Republic of 50612

Sponsors and Collaborators

  • Pusan National University Yangsan Hospital

Investigators

  • Principal Investigator: Sang Yeoup Lee, MD, Integrated Research Institute for Natural Ingredients and Functional Foods

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Sang Yeoup Lee, Principal Investigator, Professor, Head of Integrated Research Institute for Natural Ingredients and Functional Foods (IRINIF), Pusan National University Yangsan Hospital
ClinicalTrials.gov Identifier:
NCT03505684
Other Study ID Numbers:
  • 02-2017-033
First Posted:
Apr 23, 2018
Last Update Posted:
Aug 28, 2018
Last Verified:
Aug 1, 2018
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of Aug 28, 2018