Impact of Sleep Restriction on Performance in Adults
Study Details
Study Description
Brief Summary
The overall goal of this project is to look at the effects of long-term, sustained sleep restriction (SR) in adults, and assess the effects on mood and cognitive and physical performance.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Chronic Sleep Restriction (SR) is highly prevalent in today's modern society. Artificial light, portable electronic devices, and 24-h services have allowed individuals to remain active throughout the night, leading to reductions in sleep duration. SSD has been linked to obesity and our laboratory has been interested in establishing whether sleep could be a causal factor in the etiology of obesity. Given the increasing prevalence of obesity over the past 5 decades, coinciding with the marked reduction in sleep duration, further exploration into the role of sleep as a risk factor for obesity could provide additional ammunition in the fight to prevent further increases in the incidence of obesity.
This study will be a randomized, crossover, outpatient SR study with 2 phases of 6 weeks each, with a 6 week wash-out period between the phases. Sleep duration in each phase will be the participant's regular bed- and wake times during the habitual sleep (HS) phase and HS minus 1.5 hours in the SR phase. During the HS phase, participants will be asked to follow a fixed bedtime routine based on their screening sleep schedule. During the SR phase, participants will be asked to keep their habitual wake time constant but delay their bedtime to achieve a reduction of 1.5 hours in total sleep time.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| No Intervention: Habitual Sleep (HS) Participants will be asked to follow a fixed bedtime routine based on the participant's regular bed- and wake-times during the habitual sleep (HS) phase. |
|
| Experimental: Sleep Restriction (SR) Participants will be asked to keep their habitual wake time constant but delay their bedtime to achieve a reduction of 1.5 hours in total sleep time during the sleep restriction (SR) phase. |
Behavioral: Sleep Restriction (SR)
Participants will be asked to keep their habitual wake time constant but delay their bedtime to achieve a reduction of 1.5 hours in total sleep time. A delay in bedtimes was chosen rather than advancing wake-up time because it most closely reflects differences in sleep timing behavior between short and normal sleepers.
|
Outcome Measures
Primary Outcome Measures
- Change in Fat Mass [Baseline, Week 6 (endpoint)]
Body composition (specifically fat mass) will be measured by MRI at baseline and endpoint.
Secondary Outcome Measures
- Energy Expenditure (EE) [Weeks 5 and 6 (endpoint)]
EE is the amount of energy (or calories) that a person needs to carry out physical functions and will be assessed using Doubly Labeled Water (DLW), during the last 2 weeks of each sleep phase.
- Physical activity [6 weeks (measured daily)]
Time spent in sedentary, light, moderate, and moderate-to-vigoroud physical activity.
- Appetite-regulating hormones [Baseline, Week 6 (endpoint)]
Ghrelin, leptin, glucagon-like peptide 1, orexin, NPY
- Neuronal activity [Week 6]
Neuronal activity at rest and in response to food stimuli
Other Outcome Measures
- NIH Toolbox® for Assessment of Neurological and Behavioral Function (NIH Toolbox) [Baseline, Week 6 (endpoint)]
Measure cognitive, emotional, sensory, and motor functions, raw scores
- Neuro-behavioral measures [Baseline, Week 6 (endpoint)]
ModRey memory task
- Immune function [Baseline, Week 6 (endpoint)]
T-cell stimulation
- Immune markers [Baseline, Week 6 (endpoint)]
White blood cell populations
- Activity [Week 5]
6-minute walk test
Eligibility Criteria
Criteria
Inclusion Criteria:
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BMI 25-29.9 kg/m2
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Have at least one obese parent
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Habitually sleep 7-9 hours a night
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Free of any current and past sleep and psychiatric disorders, including eating disorders, diabetes or Cardiovascular disease (CVD) (i.e., normal scores on: Pittsburgh Quality of Sleep Questionnaire Epworth Sleepiness Scale, Berlin Questionnaire, Sleep Disorders Inventory Questionnaire, Beck Depression Inventory, Composite Scale of Morningness/Eveningness, Three Factor Eating Questionnaire)
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All racial/ethnic groups
Exclusion Criteria:
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Smokers (any cigarettes or ex-smoker < 3 years)
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Neurological, medical or psychiatric disorder
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Diabetics
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Eating and/or sleep disorders
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Contraindications for MRI scanning
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Travel across time zones within 4 weeks
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History of drug and alcohol abuse
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Shift worker (or rotating shift worker)
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Caffeine intake > 300 mg/d
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Heavy equipment operators
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Commercial long-distance drivers
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | New York Nutrition Obesity Research Center | New York | New York | United States | 10032 |
Sponsors and Collaborators
- Columbia University
- NYU Langone Health
- National Heart, Lung, and Blood Institute (NHLBI)
Investigators
- Principal Investigator: Marie Pierre St-Onge, PhD, Columbia University
Study Documents (Full-Text)
None provided.More Information
Publications
- Keith SW, Redden DT, Katzmarzyk PT, Boggiano MM, Hanlon EC, Benca RM, Ruden D, Pietrobelli A, Barger JL, Fontaine KR, Wang C, Aronne LJ, Wright SM, Baskin M, Dhurandhar NV, Lijoi MC, Grilo CM, DeLuca M, Westfall AO, Allison DB. Putative contributors to the secular increase in obesity: exploring the roads less traveled. Int J Obes (Lond). 2006 Nov;30(11):1585-94. Epub 2006 Jun 27. Review.
- Luckhaupt SE, Tak S, Calvert GM. The prevalence of short sleep duration by industry and occupation in the National Health Interview Survey. Sleep. 2010 Feb;33(2):149-59.
- Makarem N, Zuraikat FM, Aggarwal B, Jelic S, St-Onge MP. Variability in Sleep Patterns: an Emerging Risk Factor for Hypertension. Curr Hypertens Rep. 2020 Feb 21;22(2):19. doi: 10.1007/s11906-020-1025-9. Review.
- Zuraikat FM, Makarem N, Redline S, Aggarwal B, Jelic S, St-Onge MP. Sleep Regularity and Cardiometabolic Heath: Is Variability in Sleep Patterns a Risk Factor for Excess Adiposity and Glycemic Dysregulation? Curr Diab Rep. 2020 Jul 23;20(8):38. doi: 10.1007/s11892-020-01324-w. Review.
- AAAQ7746
- 1R01HL128226-01A1