RRx-001 in Lung Cancer, Ovarian Cancer and Neuroendocrine Tumors Prior to Re-administration of Platinum Based Doublet Regimens (QUADRUPLE THREAT)
Study Details
Study Description
Brief Summary
This study is designed to explore the potential of the epigenetic agent RRx-001 to sensitize patients who previously received and now have failed a platinum based doublet regimen. RRx-001 is administered with autologous blood once weekly followed by or in combination with reintroduction of platinum-based doublet therapy.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
Phase 2 |
Detailed Description
This is an open label, four 'cohort' study for administration of RRx-001 with autologous blood once weekly followed by or in combination with reintroduction of platinum-based doublet therapy according to the treatment schedule listed below. Small cell carcinoma and ovarian cohort participants will be randomized to 1 of 2 treatment arms, respectively. Neuroendocrine and NSCLC patients will be enrolled to single arms.
Participants with SCC will receive one of the following; RRx-001 followed by platinum doublet chemotherapy or platinum based chemotherapy alone. HGNEC, RRx-001 followed by platinum doublet chemotherapy. NSCLC, RRx-001 followed by platinum doublet chemotherapy. Participants with Platinum Refractory/Resistant Ovarian and MMMT will receive one of the following, RRx-001 followed by platinum doublet chemotherapy or chemotherapy alone.
Approximately 213 participants will be enrolled.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: Small Cell Lung Cancer (Arm 1) RRx-001 weekly for 3 weeks followed by up to 4 cycles of carboplatin or cisplatin plus etoposide and then RRx-001 and carboplatin or cisplatin (for patients with stable disease (SD) or better at discontinuation of platinum). |
Drug: RRx-001
Drug: Cisplatin
Drug: Etoposide
Drug: Carboplatin
|
Active Comparator: Small Cell Lung Cancer (Arm 2) Carboplatin or cisplatin plus etoposide or irinotecan or vinorelbine until progression or intolerable toxicity |
Drug: Cisplatin
Drug: Etoposide
Drug: Carboplatin
Drug: Irinotecan
Drug: Vinorelbine
|
Experimental: Non Small Cell Lung Cancer RRx-001 weekly for 3 weeks followed by up to 6 cycles of cisplatin or carboplatin plus paclitaxel or nab-paclitaxel or pemetrexed and then RRx-001 maintenance (for patients with stable disease or better at discontinuation of platinum). |
Drug: RRx-001
Drug: Cisplatin
Drug: Carboplatin
Drug: Paclitaxel
Drug: Nab-Paclitaxel
Drug: Pemetrexed
|
Experimental: Neuroendocrine tumors RRx-001 weekly until progression followed by up to 6 cycles of carboplatin or cisplatin plus etoposide and then RRx-001 maintenance (for patients with stable disease or better at discontinuation of platinum). |
Drug: RRx-001
Drug: Cisplatin
Drug: Etoposide
Drug: Carboplatin
|
Experimental: Ovarian epithelial cancer (Arm 1) RRx-001 weekly for 2 weeks followed by 2 cycles of Carboplatin chemotherapy and then RRx-001/Carboplatin maintenance (for patients with stable disease or better at discontinuation of platinum). |
Drug: RRx-001
Drug: Carboplatin
|
Active Comparator: Ovarian epithelial cancer (Arm 2) Carboplatin, Etoposide, Doxil, Gemcitabine or Vinorelbine or Taxane until progression or intolerable toxicity |
Drug: Etoposide
Drug: Carboplatin
Drug: Vinorelbine
Drug: Doxil
Drug: Gemcitabine
Drug: Taxane
|
Outcome Measures
Primary Outcome Measures
- Overall Survival [up to one year]
the time from enrollment until the time of death from any cause or last follow-up. Patients will be followed clinically as outlined in the treatment schedule and will be followed off study for death.
Secondary Outcome Measures
- Overall Response Rate (ORR) [12 weeks]
The proportion of patients who achieve a reduction in the sum of target lesions by 30% following the re-administration of chemotherapy. Radiographic assessment of disease burden will be evaluated by CT and disease RR will be documented using RECIST v1.1.
- Disease Control Rate (DCR) [12weeks]
The percentage of patients who have achieved complete response, partial response and stable disease (as per RECIST v1.1).
- Progression Free Survival (PFS) [12 weeks]
the time from enrollment to the time of the first radiographic documentation of objective progression as defined by RECIST v1.1 or death from any cause.
- Number of Participants with Adverse Events as a Measure of Safety and Tolerability of platinum doublet therapy post RRx-001 [12 weeks]
- Changes in the level of serum biomarkers will be calculated and treatment samples will be compared to baseline samples using one-sample tests (e.g., paired t test or Wilcoxon signed rank test). [12 weeks]
Eligibility Criteria
Criteria
Inclusion Criteria
-
Patients must have histologically or cytologically confirmed advanced or metastatic:
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Resistant/Refractory Small Cell Carcinoma (SCC) patients in 3rd line or beyond that have previously received platinum or patients in 2nd line with platinum-refractory or platinum-resistant disease
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EGFR mutated non-small cell lung cancer (NSCLC) that has previously received a first line platinum doublet and all applicable EGFR TKIs
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Epithelial Ovarian Cancer (EOC), fallopian tube or primary peritoneal cancer and Malignant Mixed Mullerian Tumor (MMMT) of the ovary or uterus. Excludes other non-epithelial ovarian tumors and ovarian tumors with low malignant potential. Patients must have previously received a platinum based regimen for advanced/metastatic disease or have platinum resistant or refractory disease defined as relapse within 6 months. EOC - specific criteria: Patients who progress or have stable disease during first-line treatment or who relapse within 1 month are considered to be 'platinum-refractory'. Patients who respond to primary treatment and relapse within 6 months are considered 'platinum-resistant', and patients who relapse more than 6 months after completion of initial therapy are characterized as 'platinum-sensitive'. Patients who relapse 6-12 months following the end of their initial regimen are classified as 'partially sensitive'. Platinum sensitive patients may be enrolled but must have failed or declined all other lines of FDA approved therapy
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High-Grade Neuroendocrine Carcinoma (HGNEC), any organ of origin, including a pathology of neuroendocrine features, in patients previously been treated with chemotherapy Although neuroendocrine tumors may be classified differently based on organ of origin, in the context of this protocol they are defined as high grade on the basis of either
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Aggressive clinical behavior requiring previous treatment with chemotherapy even if histologic features such as the Ki67 index or mitotic rate corresponds with low or intermediate grade.
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Histologic features: (a) Neuroendocrine tumors of lung origin are considered high grade if in any part of the tumors, there are >10 mitoses/2mm2 or 10 high power field (HPF). Large zones of necrosis are usually present. This includes small cell lung carcinoma and large cell neuroendocrine lung carcinoma. [SCLC will not enroll in the HGNEC cohort.] (b)Neuroendocrine tumors of gastroenteropancreatic origin are considered high grade if in any part of the tumors there are either >20 mitoses/2mm2 or 10 high power field (HPF) OR Ki67.
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Radiographically measurable disease by RECIST v1.1
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A washout period of 3-weeks from last treatment.
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Patients must have previously received a platinum based regimen for advanced/metastatic disease and progressed or have platinum resistant or refractory disease defined as relapse within 6 months.
-
Age ≥18 years.
-
Life expectancy of ≥12 weeks.
-
ECOG performance status 0-2.
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Participants must have adequate organ and marrow function as defined below both prior to administration of RRx-001 and prior to administration of platinum doublet based regimen:
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Absolute neutrophil count ≥1,500/mcL
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Platelets ≥100,000/mcL (non-transfused platelet count)
-
Hemoglobin ≥9 g/dL (transfused Hgb allowed)
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Creatinine ≤1.5 x the upper limit of normal
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Total bilirubin ≤2.0 x the upper limit of normal or <3.0 xULN if patient has a history of Gilbert's syndrome
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AST (SGOT)/ALT (SGPT) ≤5 X institutional upper limit of normal if with liver metastases; ≤2.5 X ULN if no liver metastases
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Patient must consent to the access, review and analysis of previous medical and cancer history, including tumor archival tissue (if available) and imaging data by the sponsor or a third party nominated by the sponsor.
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Ability to understand and sign a written informed consent document.
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Women of child-bearing potential and men with partners of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 90 days following completion of therapy.
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Note: A woman of child-bearing potential is any female (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria: Has not undergone a hysterectomy or bilateral oophorectomy; or Has not been postmenopausal for at least 12 consecutive months
Exclusion Criteria
-
Receiving concurrent investigational therapy
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Symptomatic central nervous system metastasis (e.g., patients requiring increasing doses of steroids)
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History of needing to permanently discontinue prior platinum doublet-based regimen for toxicity (e.g., cisplatin causing renal impairment, ototoxicity, or severe neuropathy).
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Known severe hypersensitivity to the platinum agent (i.e., carboplatin or cisplatin) or prior partner of platinum agent (i.e., etoposide for SCC and HGNEC; nab-paclitaxel, paclitaxel, or pemetrexed for NSCLC; paclitaxel, pegylated liposomal doxorubicin, docetaxel or gemcitabine for ovarian) planned for the platinum therapy period. If the patient has had prior hypersensitivity reaction to the drug partner of platinum, a patient may enroll as long as it is acceptable to treat with platinum and one of the alternative chemotherapy partner agents.
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Any significant medical diseases or conditions, as assessed by the investigators and sponsor that would substantially increase the medical risks of participating in this study (i.e., uncontrolled diabetes, NYHA II-IV congestive heart failure, myocardial infarction within 6 months of study, severe chronic pulmonary disease or active uncontrolled infection, uncontrolled or clinically relevant pulmonary edema).
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Pregnant or nursing
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Stanford University | Palo Alto | California | United States | 94304 |
2 | VA Connecticut Cancer Center | West Haven | Connecticut | United States | 06516 |
3 | Memorial Hospital of South Bend | South Bend | Indiana | United States | 46601 |
4 | Baptist Health | Lexington | Kentucky | United States | 40503 |
5 | Walter Reed National Military Medical Center | Bethesda | Maryland | United States | 20889 |
6 | Henry Ford Allegiance Health | Jackson | Michigan | United States | 49201 |
7 | Washington University | Saint Louis | Missouri | United States | 63110 |
8 | University of Cincinnati Cancer Institute | Cincinnati | Ohio | United States | 45267 |
9 | Virginia Cancer Specialists | Fairfax | Virginia | United States | 22031 |
10 | West Virginia University | Morgantown | West Virginia | United States | 26506 |
Sponsors and Collaborators
- EpicentRx, Inc.
Investigators
- Study Director: Bryan Oronsky, MD, PhD, EpicentRx, Inc.
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- RRx001-211-01