Study of Everolimus (RAD001) in Combination With Lenalidomide

Sponsor
Emory University (Other)
Overall Status
Completed
CT.gov ID
NCT01218555
Collaborator
Celgene (Industry), Novartis (Industry)
44
2
1
121.9
22
0.2

Study Details

Study Description

Brief Summary

The purpose of this study is to study the combination of two anticancer drugs, everolimus (RAD001) and lenalidomide in patients whose cancer is no longer responding to standard treatment or patients who are unable to tolerate the standard treatment for their cancer.

Detailed Description

The purpose of this study is to study the combination of two anticancer drugs, everolimus (RAD001) and lenalidomide in patients whose cancer is no longer responding to standard treatment or patients who are unable to tolerate the standard treatment for their cancer. The investigators seek to establish the safety of taking these two medications together and to determine the appropriate doses of the two drugs when given together as well as identify potential side effects when the drugs are administered together.

Another purpose of this study is to find out if the medication works for the patient's kind of cancer and side effects of the combination of RAD001 and lenalidomide by looking at the patient's response to the treatment. The investigators want to find out what effects, good or bad, the drugs have on the patient's cancer.

This study will also look at specific substances called biomarkers in the patient's blood and in the tumor tissue which are involved in the growth of tumor cells and determine if the levels of these biomarkers are related to the patient's response to treatment or development of side effects.

An expansion cohort is currently enrolling patients with adenoidcystic carcinoma, neuroendocrine and kidney cancer.

Study Design

Study Type:
Interventional
Actual Enrollment :
44 participants
Allocation:
N/A
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
Phase I Study of Everolimus (RAD001) in Combination With Lenalidomide in Patients With Advanced Solid Malignancies Enriched for Renal Cell Carcinoma
Actual Study Start Date :
Sep 9, 2010
Actual Primary Completion Date :
Nov 5, 2020
Actual Study Completion Date :
Nov 5, 2020

Arms and Interventions

Arm Intervention/Treatment
Experimental: Lenalidomide combination with everolimus

Non-randomized study of escalating doses of daily, orally administered lenalidomide in combination with standard doses of everolimus, an orally available mammalian target of rapamycin (mTOR) inhibitor.

Drug: Lenalidomide
Lenalidomide (10mg, 15mg, 20mg or 25mg) once daily by mouth, every day of each 28-day cycle.
Other Names:
  • Revlimid
  • Drug: Everolimus
    5mg or 10mg of everolimus administered once daily by mouth on a once daily continuous dosing schedule for 28 days.
    Other Names:
  • RAD001
  • Afinitor
  • Outcome Measures

    Primary Outcome Measures

    1. Number of Participants With Dose Limiting Toxicities (DLT) at Each Dose Level [Within the first 28 days for DLT and throughout the duration of the study for safety.]

      A standard 3 + 3 design was employed to study escalating doses of daily, orally administered lenalidomide and everolimus. Dose escalation to the next cohort required 0 of 3 or ≤1 of 6 patients with dose-limiting toxicity (DLT). Five dose cohorts were planned starting at dose level one with lenalidomide 10 mg and everolimus 5mg in a 28-day cycle up to maximum doses of 25 and 10 mg, respectively.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • Subjects must meet the following inclusion/exclusion criteria to be eligible for the study.

    • Ability to understand and willingness to voluntarily sign an informed consent form.

    • Histologic or cytologic confirmation of a solid malignancy.

    • Age ≥ 18 years at the time of signing the informed consent form. Because no dosing or adverse event data are currently available on the use of everolimus in combination with lenalidomide in patients < 18 years of age, children are excluded from this study.

    • Able to adhere to the study visit schedule and other protocol requirements.

    • Patients must have at least one measurable site of disease according to Response Evaluation Criteria in Solid Tumors (RECIST) criteria that has not been previously irradiated. If the patient has had previous radiation to the marker lesion(s), there must be evidence of progression since the radiation.

    • Diagnosed with advanced refractory solid malignancies or intolerant of standard therapy for the stage of the disease (because there is currently no standard approved therapy for adenoidcystic carcinoma, therefore there is no requirement of prior therapy for this patient population).

    • All previous cancer therapy, including radiation, hormonal therapy and surgery, must have been discontinued at least 4 weeks prior to treatment in this study. A minimum of 6 weeks treatment break is required in case of nitrosoureas or mitomycin C.

    • Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 2 at study entry.

    • Able to receive prophylactic anticoagulation with aspirin, warfarin or low molecular weight heparin when required for lenalidomide administration.

    • Fasting serum cholesterol ≤ 300 mg/dL OR ≤ 7.75 mmol/L AND fasting triglycerides ≤ 2.5 x upper limit of normal (ULN). NOTE: In case one or both of these thresholds are exceeded, the patient can only be included after initiation of appropriate lipid lowering medication.

    • Laboratory test results within these ranges:

    • Absolute neutrophil count 1500 ≥ /mm³

    • Platelet count ≥ 100,000/mm³

    • Hb ≥ 9 g/dL

    • Creatinine within institutional limits of normal or creatinine clearance ≥ 60 ml/min/m² if elevated creatinine

    • Total bilirubin < 2.0 mg/dL or < 1.5.0 x ULN for the institution whichever is higher

    • Aspartate aminotransferase (AST) (SGOT) and alanine aminotransferase (ALT) (SGPT) < 2.x ULN or < 5 x ULN if hepatic metastases are present.

    • All study participants must be registered into the mandatory Revlimid Risk Evaluation and Mitigation Strategy (REMS®) program, and be willing and able to comply with the requirements of the REMS® program.

    • Females of reproductive potential must adhere to the scheduled pregnancy testing as required in the Revlimid REMS® program.

    • Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 50 milli-International Unit (mIU)/mL within 10 - 14 days prior to and again within 24 hours of prescribing lenalidomide (prescriptions must be filled within 7 days) and must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before she starts taking lenalidomide. FCBP must also agree to ongoing pregnancy testing. Men must agree to use a latex condom during sexual contact with a FCBP even if they have had a successful vasectomy.

    Exclusion Criteria:
    • Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements including signing the informed consent form.

    • Pregnant or breast feeding females. (Lactating females must agree not to breast feed while taking lenalidomide).

    • Any condition, including the presence of laboratory abnormalities, which places the subject at unacceptable risk if he/she were to participate in the study or confounds the ability to interpret data from the study.

    • Use of any other experimental drug or therapy within 28 days of baseline.

    • Known hypersensitivity to thalidomide or everolimus (including other rapamycins, sirolimus and temsirolimus).

    • The development of erythema nodosum if characterized by a desquamating rash while taking thalidomide or similar drugs.

    • Prior treatment with lenalidomide or everolimus.

    • Concurrent use of other anti-cancer agents or treatments.

    • Patients known to be positive for HIV or infectious hepatitis, type B or C requiring active therapy. Patients on combination antiviral therapy are ineligible because of the potential for pharmacokinetic interactions with everolimus and or lenalidomide. In addition, these patients are at increased risk of lethal infections when treated with marrow-suppressive therapy. Appropriate studies will be undertaken in this patient population.

    • Liver disease such as cirrhosis or severe hepatic impairment (Child-Pugh class C).

    • Symptomatic brain metastasis. Patients with treated brain metastasis must be completely weaned off of steroid therapy for at least 14 days prior to starting protocol therapy.

    • Patients receiving chronic, systemic treatment with corticosteroids or another immunosuppressive agent. Topical or inhaled corticosteroids are allowed.

    • Patients should not receive immunization with attenuated live vaccines within one week of study entry or during study period.

    • Diagnosed venous thromboembolic disease within the preceding 6 months (patient on full dose or prophylactic anticoagulation are eligible).

    • Patients receiving any medications or substances that are inhibitors or inducers of CYP450 enzyme(s) are ineligible. Lists of excluded medications and substances known or with the potential to interact with the cytochrome P450 (CYP450) enzyme(s) are provided.

    • History of other malignancies except: (i) adequately treated basal or squamous cell carcinoma of the skin; (ii) curatively treated, a) in situ carcinoma of the uterine cervix, b) prostate cancer, or c) superficial bladder cancer; or (iii) other curatively treated solid tumor with no evidence of disease for ≥ 3 years.

    • Patients, who have had a major surgery or significant traumatic injury within 4 weeks of start of study drug, patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or patients that may require major surgery during the course of the study.

    • Patients with an active, bleeding diathesis.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Grady Health System Atlanta Georgia United States 30303
    2 Emory University Winship Cancer Institute Atlanta Georgia United States 30322

    Sponsors and Collaborators

    • Emory University
    • Celgene
    • Novartis

    Investigators

    • Principal Investigator: Taofeek Owonikoko, PhD/MD, Emory University Winship Cancer Institute

    Study Documents (Full-Text)

    More Information

    Publications

    None provided.
    Responsible Party:
    Taofeek K. Owonikoko, Professor and Principal Investigator, Emory University
    ClinicalTrials.gov Identifier:
    NCT01218555
    Other Study ID Numbers:
    • IRB00031088
    • WCI1717-09
    First Posted:
    Oct 11, 2010
    Last Update Posted:
    Jan 27, 2022
    Last Verified:
    Nov 1, 2021
    Keywords provided by Taofeek K. Owonikoko, Professor and Principal Investigator, Emory University
    Additional relevant MeSH terms:

    Study Results

    Participant Flow

    Recruitment Details
    Pre-assignment Detail
    Arm/Group Title Dose Level 1 Lenalidomide/Everolimus 10/5 mg Dose Level 2 Lenalidomide/Everolimus Dose Level 3: Lenalidomide/Everolimus Dose Level 4: Lenalidomide/Everolimus 20/5/mg Dose Level 5: Lenalidomide/Everolimus (25/10mg) RP2D: L (25mg) and E (10mg)
    Arm/Group Description Participants were administered with lenalidomide 10 mg and everolimus 5mg once daily by mouth, every day of each 28-day cycle. Participants were administered 15/5 of lenalidomide/everolimus once daily by mouth, every day of each 28-day cycle. Patients were administered 20/5/mg of lenalidomide/everolimus once daily by mouth, every day of each 28-day cycle. Participants were administered with lenalidomide 25 mg and everolimus 5mg once daily by mouth, every day of each 28-day cycle. Participants were administered with lenalidomide 25 mg and everolimus 10mg once daily by mouth, every day of each 28-day cycle. Participants were administered with lenalidomide 25 mg and everolimus 10mg once daily by mouth, every day of each 28-day cycle.
    Period Title: Overall Study
    STARTED 3 3 5 3 8 22
    COMPLETED 3 3 5 3 8 22
    NOT COMPLETED 0 0 0 0 0 0

    Baseline Characteristics

    Arm/Group Title Lenalidomide Combination With Everolimus
    Arm/Group Description Non-randomized study of escalating doses of daily, orally administered lenalidomide in combination with standard doses of everolimus, an orally available mammalian target of rapamycin (mTOR) inhibitor. Lenalidomide: Lenalidomide (10mg, 15mg, 20mg or 25mg) once daily by mouth, every day of each 28-day cycle. Everolimus: 5mg or 10mg of everolimus administered once daily by mouth on a once daily continuous dosing schedule for 28 days.
    Overall Participants 44
    Age (Years) [Mean (Standard Deviation) ]
    Mean (Standard Deviation) [Years]
    58
    (44)
    Sex: Female, Male (Count of Participants)
    Female
    16
    36.4%
    Male
    28
    63.6%
    Ethnicity (NIH/OMB) (Count of Participants)
    Hispanic or Latino
    3
    6.8%
    Not Hispanic or Latino
    40
    90.9%
    Unknown or Not Reported
    1
    2.3%
    Race (NIH/OMB) (Count of Participants)
    American Indian or Alaska Native
    0
    0%
    Asian
    4
    9.1%
    Native Hawaiian or Other Pacific Islander
    0
    0%
    Black or African American
    8
    18.2%
    White
    32
    72.7%
    More than one race
    0
    0%
    Unknown or Not Reported
    0
    0%
    Region of Enrollment (participants) [Number]
    United States
    44
    100%

    Outcome Measures

    1. Primary Outcome
    Title Number of Participants With Dose Limiting Toxicities (DLT) at Each Dose Level
    Description A standard 3 + 3 design was employed to study escalating doses of daily, orally administered lenalidomide and everolimus. Dose escalation to the next cohort required 0 of 3 or ≤1 of 6 patients with dose-limiting toxicity (DLT). Five dose cohorts were planned starting at dose level one with lenalidomide 10 mg and everolimus 5mg in a 28-day cycle up to maximum doses of 25 and 10 mg, respectively.
    Time Frame Within the first 28 days for DLT and throughout the duration of the study for safety.

    Outcome Measure Data

    Analysis Population Description
    [Not Specified]
    Arm/Group Title Lenalidomide Combination With Everolimus
    Arm/Group Description Non-randomized study of escalating doses of daily, orally administered lenalidomide in combination with standard doses of everolimus, an orally available mammalian target of rapamycin (mTOR) inhibitor. Lenalidomide: Lenalidomide (10mg, 15mg, 20mg or 25mg) once daily by mouth, every day of each 28-day cycle. Everolimus: 5mg or 10mg of everolimus administered once daily by mouth on a once daily continuous dosing schedule for 28 days.
    Measure Participants 44
    Lenalidomide/everolimus (10/5 mg)
    3
    6.8%
    Lenalidomide/everolimus(15/5 mg)
    3
    6.8%
    Lenalidomide/everolimus(20/5 mg)
    5
    11.4%
    Lenalidomide/everolimus(25/5 mg)
    3
    6.8%
    Lenalidomide/everolimus(25/10 mg)
    8
    18.2%
    Recommended Phase 2Dose: L (25mg) and E (10mg)
    22
    50%

    Adverse Events

    Time Frame Adverse events collected through study completion, an average of 1 year.
    Adverse Event Reporting Description
    Arm/Group Title Lenalidomide Combination With Everolimus
    Arm/Group Description Adverse Events were collected irrespective of dose administered and it is therefore not possible to report using separate Arms/Groups).
    All Cause Mortality
    Lenalidomide Combination With Everolimus
    Affected / at Risk (%) # Events
    Total 18/44 (40.9%)
    Serious Adverse Events
    Lenalidomide Combination With Everolimus
    Affected / at Risk (%) # Events
    Total 18/44 (40.9%)
    General disorders
    All-Cause Mortality 18/44 (40.9%)
    Other (Not Including Serious) Adverse Events
    Lenalidomide Combination With Everolimus
    Affected / at Risk (%) # Events
    Total 38/44 (86.4%)
    Gastrointestinal disorders
    Anorexia 11/44 (25%)
    Diarrhea 13/44 (29.5%)
    Nausea 11/44 (25%)
    General disorders
    Fatigue 15/44 (34.1%)
    Metabolism and nutrition disorders
    ALT 7/44 (15.9%)
    Elevated AST 5/44 (11.4%)
    Skin and subcutaneous tissue disorders
    Rash 9/44 (20.5%)

    Limitations/Caveats

    [Not Specified]

    More Information

    Certain Agreements

    All Principal Investigators ARE employed by the organization sponsoring the study.

    There is NOT an agreement between Principal Investigators and the Sponsor (or its agents) that restricts the PI's rights to discuss or publish trial results after the trial is completed.

    Results Point of Contact

    Name/Title Taofeek K. Owonikoko, MD, PhD, MSCR
    Organization Emory University
    Phone 404-778-1900
    Email towonik@emory.edu
    Responsible Party:
    Taofeek K. Owonikoko, Professor and Principal Investigator, Emory University
    ClinicalTrials.gov Identifier:
    NCT01218555
    Other Study ID Numbers:
    • IRB00031088
    • WCI1717-09
    First Posted:
    Oct 11, 2010
    Last Update Posted:
    Jan 27, 2022
    Last Verified:
    Nov 1, 2021