The Molecular Imaging Research of F-18 Labeled DX600 PET Probe
Study Details
Study Description
Brief Summary
Angiotensin-converting enzyme 2 (ACE2) plays an important role in renin-angiotensin system (RAS) and has been reported to relate with cancer. Recently, it has also been proved as the key target for COVID-19 infection.
DX600 is a polypeptide that can specific binding to ACE2 specifically with nanomolar affinity reported in literature. This study constrcuted a radio-tracer, DX600 Labeled by PET Radionuclide, to monitoring biodistribution ACE2 in human beings, evaluate the detection ability of radio-tracer in ACE2 over-expression tumors and dynamic changes of ACE2 expression under therapy.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: Imaging cohort All study participants will be allocated to this arm (single-arm study). Study participants will undergo 18F-DX600 PET/CT scans. |
Other: 18F-DX600 PET/CT
DX600, labeled with 18F will be used as a molecular imaging tracer for PET/CT scanning
|
Outcome Measures
Primary Outcome Measures
- Standard uptake value (SUV) [2 years]
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age >3 years old; both sex;
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ECoG 0 or 1;
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Patients that would undergo biopsy or surgical operation with high ACE2 expression tumors such as colorectal cancer, renal cancer, pancreatic cancer, gastric cancer, liver cancer, lung cancer, brain cancer or suspected tumor.
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use 18F-FDG PET/CT as baseline evaluation
Exclusion Criteria:
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Significant hepatic or renal dysfunction;
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Is Pregnant or ready to pregnant;
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Cannot lie on their back for half an hour;
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Suffering from claustrophobia or other mental diseases;
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Refusal to join the clinical study;
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Beijing Cancer Hospital | Beijing | Beijing | China | 100142 |
Sponsors and Collaborators
- Peking University Cancer Hospital & Institute
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2020KT102