SLAM-PD: Speech, Linguistic and Acoustic Markers in Parkinson's Disease
Study Details
Study Description
Brief Summary
The Investigators aim to identify speech and language markers that provide information on cognitive function and predict cognitive decline in Parkinson's disease. The Investigators will administer speech tasks and cognitive assessments to participants with Parkinson's disease and healthy controls. The Investigators will also explore the associations between genetic factors and speech and cognitive status in Parkinson's disease.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Parkinson's Disease Subjects with Parkinson's Disease |
Diagnostic Test: Cognitive Battery
Participants will be asked to complete a series of cognitive testing (testing of concentration, memory, and other thinking abilities).
Behavioral: Voice, Speech and Language Analysis
Participants will be asked to perform speaking and reading tasks, which will be recorded. Participants will be asked to complete a laptop-based test of language comprehension.
Behavioral: Questionnaires and Clinical Assessments
Participants with Parkinson's disease will complete an examination of their symptoms and questionnaires assessing disease symptoms, mood and activities of daily living. Healthy controls participants will be asked to complete questionnaires on mood.
Genetic: DNA Analysis
Participants will have their blood drawn for DNA analysis.
|
| Control Subjects without Parkinson's Disease |
Diagnostic Test: Cognitive Battery
Participants will be asked to complete a series of cognitive testing (testing of concentration, memory, and other thinking abilities).
Behavioral: Voice, Speech and Language Analysis
Participants will be asked to perform speaking and reading tasks, which will be recorded. Participants will be asked to complete a laptop-based test of language comprehension.
Behavioral: Questionnaires and Clinical Assessments
Participants with Parkinson's disease will complete an examination of their symptoms and questionnaires assessing disease symptoms, mood and activities of daily living. Healthy controls participants will be asked to complete questionnaires on mood.
|
Outcome Measures
Primary Outcome Measures
- Detection of speech acoustic parameters that classify PD participants by cognitive status (mild cognitive impairment [MCI] vs. normal cognition) [12-24 months]
Gaussian regression modeling and other machine learning techniques will be used to develop a model including fundamental frequency, noise-to-harmonic ratio, cepstral peak prominence, formants, phoneme-dependent speaking rates and diadochokinesis rate and quality to predict categorization of PD participants by disease and cognitive status.
- Duration and location of pauses during speech in PD participants with and without mild cognitive impairment [12-24 months]
Participants will produce speech samples of spontaneous speech, which will be transcribed and coded for pause length and location, and these characteristics will be entered into a non-linear mixed model with the three-level predictor of group membership (control, PD-MCI, PD with normal cognition) as the parameter of interest.
- Syntax processing efficiency score (percentage correctly understood sentences/processing time) in controls, and in PD with and without MCI [12-24 months]
When presented with sentences of varying syntactical complexity in a self-paced task, participants response time and accuracy will be used to create multilevel models and test for effect of group (controls, PD, PD-MCI).
Eligibility Criteria
Criteria
Inclusion Criteria:
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Parkinson's Disease (or healthy control)
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Disease duration ≥ 2 years
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Mild cognitive impairment or normal cognition
Exclusion Criteria:
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Diagnosis of dementia (MoCA <21)
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Adults unable to consent
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Age < 18
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Pregnant women
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Prisoners
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Non-English speakers
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Any neurological disorder other than PD
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Deep brain stimulator placement
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Severe, unstable psychiatric disorder
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Unintelligible speech due to effects of PD
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Visual acuity or color vision impairment that would interfere with cognitive testing
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Other voice, speech or swallowing disorders or history of surgery involving palate/nasopharynx/larynx/vocal cords
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | UMass Medical School/UMass Memorial Medical Center | Worcester | Massachusetts | United States | 01655 |
Sponsors and Collaborators
- University of Massachusetts, Worcester
- Massachusetts Institute of Technology, Lincoln Laboratories
- Boston University
- VA Puget Sound Health Care System
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Investigators
- Principal Investigator: Kara Smith, MD, UMass Medical School
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- H00011523
- 5K23DC016656