Combining PAS to Non-invasive VNS
Study Details
Study Description
Brief Summary
Vagus nerve stimulation (VNS) and paired associative stimulation (PAS) have been shown to have efficacy in improving the results of motor rehabilitation after stroke and spinal cord injury, respectively. Here we will investigate in healthy subjects the synergistic effect of these stimulation modalities on motor-evoked potential (MEP) potentiation.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: PAS and VNS
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Device: PAS
Paired associative stimulation is a combination of non-invasive transcranial magnetic stimulation (TMS) and non-invasive peripheral nerve stimulation (PNS)
Device: VNS
Non-invasive vagus nerve stimulation delivered through cymba concha & cymba cavum of the ear.
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Active Comparator: PAS and sham VNS
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Device: PAS
Paired associative stimulation is a combination of non-invasive transcranial magnetic stimulation (TMS) and non-invasive peripheral nerve stimulation (PNS)
|
Active Comparator: PAS
|
Device: PAS
Paired associative stimulation is a combination of non-invasive transcranial magnetic stimulation (TMS) and non-invasive peripheral nerve stimulation (PNS)
|
Active Comparator: VNS
|
Device: VNS
Non-invasive vagus nerve stimulation delivered through cymba concha & cymba cavum of the ear.
|
Outcome Measures
Primary Outcome Measures
- Motor evoked potential (MEP) potentiation [0 minutes after the stimulation protocol]
MEPs are responses to transcranial magnetic stimulation recorded from target muscles.
- Motor evoked potential (MEP) potentiation [30 minutes after the stimulation protocol]
MEPs are responses to transcranial magnetic stimulation recorded from target muscles.
- Motor evoked potential (MEP) potentiation [60 minutes after the stimulation protocol]
MEPs are responses to transcranial magnetic stimulation recorded from target muscles.
- Motor evoked potential (MEP) potentiation [90 minutes after the stimulation protocol]
MEPs are responses to transcranial magnetic stimulation recorded from target muscles.
Eligibility Criteria
Criteria
Exclusion Criteria:
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contraindications to TMS (e.g. brain pathology, implanted devices)
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contraindications to MRI (e.g. MRI incompatible implants)
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continuous use of CNS-active drugs
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neurological, psychiatric or cardiovascular disease
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drug abuse
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Helsinki University Hospital | Helsinki | Finland |
Sponsors and Collaborators
- Helsinki University Central Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Dawson J, Pierce D, Dixit A, Kimberley TJ, Robertson M, Tarver B, Hilmi O, McLean J, Forbes K, Kilgard MP, Rennaker RL, Cramer SC, Walters M, Engineer N. Safety, Feasibility, and Efficacy of Vagus Nerve Stimulation Paired With Upper-Limb Rehabilitation After Ischemic Stroke. Stroke. 2016 Jan;47(1):143-50. doi: 10.1161/STROKEAHA.115.010477. Epub 2015 Dec 8.
- Shulga A, Lioumis P, Kirveskari E, Savolainen S, Mäkelä JP. A novel paired associative stimulation protocol with a high-frequency peripheral component: A review on results in spinal cord injury rehabilitation. Eur J Neurosci. 2021 May;53(9):3242-3257. doi: 10.1111/ejn.15191. Epub 2021 Mar 29. Review.
- UAK1022001