CHANCE-2: Clopidogrel With Aspirin in High-risk Patients With Acute Non-disabling Cerebrovascular Events II
Study Details
Study Description
Brief Summary
The primary objective of this trial is to assess the effects of ticagrelor plus aspirin versus clopidogrel plus aspirin on reducing the 3-month risk of any stroke (both ischemic and hemorrhagic, primary outcome) when initiated within 24 hours of symptom onset in CYP2Y19 LOF alleles carriers with TIA or minor stroke.
Condition or Disease | Intervention/Treatment | Phase |
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Phase 3 |
Detailed Description
According to the Global Burden of Disease(GBD) Study 2016, China bears the greatest lifetime risk of stroke from 25-year-age onward. Minor ischemic events, including minor stroke and TIA, were major parts of stroke manifestations. Events (CHANCE) has shown that 21-day dual antiplatelet therapy (clopidogrel and aspirin) compared to aspirin alone which initiated within 24 hours after symptoms onset would reduce 32% risk of stroke recurrence within 90 day, but not in carriers of CYP2C19 loss-of-function (LOF) alleles. The primary purpose of this study is to compare ticagrelor plus aspirin with clopidogrel plus aspirin on reducing the 3-month risk of any stroke (both ischemic and hemorrhagic, primary outcome) when initiated within 24 hours of symptom onset in CYP2Y19 LOF alleles carriers with TIA or minor stroke.
Both intent analysis (ITT) and compliance program set (PPS) were used for analysis.
We will use Kaplan-Meier estimates of the cumulative risk of stroke (ischemic or hemorrhagic) event during maximum 90-day follow-up, with hazards ratios and 95% CI calculated using Cox proportional hazards methods and the log-rank test to evaluate the treatment effect. All statistics will be 2-sided with P<0.05 considered significant, accounting for interim analyses.
All patients who received study drugs and with at least one safety follow-up record will be included in the safety population. The data for safety evaluation included adverse reactions observed during the trial and changes in laboratory data before and after treatment.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: Ticagrelor plus Aspirin Group Ticagrelor of loading dosing of 180mg followed by 90mg bid for 3 months plus aspirin of loading dose of 75-300mg followed by 75mg daily for 21 days |
Drug: Ticagrelor and Aspirin
Day of randomization:
Day1:Ticagrelor 180mg; placebo of clopidogrel 300mg; aspirin 75-300mg (open label) Day2-21st: Ticagrelor 90mg bid/day; placebo of clopidogrel 75mg; aspirin 75mg (open label) Day 22nd-3 months:Ticagrelor 90mg bid/day; placebo of clopidogrel 75mg
|
Active Comparator: Clopidogrel plus Aspirin Group Clopidogrel of loading dosing of 300mg followed by 75mg daily for 3 months plus aspirin loading dose of 75-300mg followed by 75mg daily for 21 days |
Drug: Clopidogrel and Aspirin
Day of randomization:
Day 1: Clopidogrel 300mg; placebo of ticagrelor 180mg; aspirin 75-300mg (open label) Day2-21st: Clopidogrel 75mg/day; placebo of ticagrelor 90mg bid/day; aspirin 75mg (open label) Day 22nd-3 months:Clopidogrel 75mg; placebo of ticagrelor 90mg bid/day
|
Outcome Measures
Primary Outcome Measures
- Any new stroke events (ischemic stroke or hemorrhagic stroke) within 3 months [3 months after randomization]
The aim is to assess the effects of ticagrelor plus aspirin versus clopidogrel plus aspirin on reducing the 3-month risk of any stroke (both ischemic and hemorrhagic, primary outcome) when initiated within 24 hours of symptom onset in CYP2Y19 LOF alleles carriers with TIA or minor stroke.
Secondary Outcome Measures
- Any new stroke events within 30 days and 1 year [30 days and 1 year after randomization]
Percentage of patients with the 30 days and 1 year new stroke events (ischemic stroke/ hemorrhagic stroke) as a cluster and evaluated individually.
- New clinical vascular events including stroke, TIA, myocardial infarction, and vascular deaths within 3 months and 1 year [3 months and 1 year after randomization]
Percentage of patients with the 3 months and 1 year new clinical vascular events (ischemic stroke/ hemorrhagic stroke/ TIA/ myocardial infarction/vascular death)
- New ischemic stroke within 3 months and 1 year [3 months and 1 year after randomization]
Percentage of patients with the 3 months and 1 year new ischemic stroke will be evaluated.
- Disabling stroke (Modified Rankin Scale score, mRS>1) at 3 months and 1 year [3 months and 1 year after randomization]
Modified Rankin Scale, a commonly used scale for measuring the degree of dependence in the daily activities of people who have suffered a stroke or other causes of neurological disability. 0 - No symptoms.1 - No significant disability. Able to carry out all usual activities, despite some symptoms.2 - Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities.3 - Moderate disability. Requires some help, but able to walk unassisted.4 - Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted.5 - Severe disability. Requires constant nursing care and attention, bedridden, incontinent.6 - Dead. The mRS scores between 3 to 6 points are considered to be poor functional outcome. (dead).
- Incidence and severity of recurrent stroke and TIA during follow-up to 3 months and 1-year [3 months and 1 year after randomization]
(Severity is measured using a six-level ordered categorical scale that incorporates the mRS: fatal stroke/severe non-fatal stroke [mRS 4 or 5]/moderate stroke [mRS 2 or 3]/mild stroke [mRS 0 or 1]/TIA/no stroke-TIA).
- Neurological impairment at 3 months (NIHSS increased≥4 from baseline) [3 months after randomization]
The National Institutes of Health Stroke Scale (NIHSS) score classifies neurologic deficit from 0 (no deficit) to 42 (most severe).
- Quality of Life (EuroQol EQ-5D scale) at 3 months and at 1 year [3 months and 1 year after randomization]
Further efficacy exploratory analysis:Quality of Life (EuroQol EQ-5D scale). We will use the EQ-5D-5L scale to evaluate the quality of life. EQ-5D-5L is a standardized instrument for measuring generic health status. It has been widely used in population health surveys, clinical studies, economic evaluation and in routine outcome measurement in the delivery of operational healthcare. The EQ-5D-5L has five domain scales (mobility, self-care, usual activities, pain and discomfort, and anxiety and depression) and five levels for each domain.
- Stratified analysis [3 months and 1 year after randomization]
The influence on treatment effect of age, gender, Body Mass Index (BMI), index event type (TIA vs. minor stroke), time from index event to randomization, etiology subtype, diabetes mellitus, hypertension, type of LOF allele, previous ischemic stroke or TIA, prior antiplatelet therapy, prior statin therapy, prior smoking status, and symptomatic intracranial and extracranial artery stenosis will be evaluated in subgroup analyses.
Other Outcome Measures
- Moderate and severe bleeding events according to the GUSTO criteria [3 months after randomization]
Severe bleeding incidence (GUSTO definition), including fatal bleeding and symptomatic intracranial hemorrhage.
- Moderate and severe bleeding events according to the GUSTO criteria [1 year after randomization]
Severe bleeding incidence (GUSTO definition), including fatal bleeding and symptomatic intracranial hemorrhage.
- All bleeding events [3 months and 1 year after randomization]
All bleeding events (severe/moderate bleeding and intracranial hemorrhage)
- Total mortality [3 months and 1 year after randomization]
Total mortality
- Incidence symptomatic intracranial hemorrhagic events [3 months and 1 year after randomization]
Incidence symptomatic intracranial hemorrhagic events
- Adverse events [3 months and 1 year after randomization]
Adverse events
Eligibility Criteria
Criteria
Inclusion Criteria
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40 years or older than 40 years;
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Acute cerebral ischemic event due to:
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Acute non-disabling ischemic stroke (NIHSS≤3 at the time of randomization)or,
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TIA with moderate-to-high risk of stroke (ABCD2 score ≥ 4 at the time of randomization);
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Can be treated with study drug within 24 hours of symptoms onset*(*Symptom onset is defined by the "last seen normal" principle);
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CYP2C19 loss-of-function allele carriers;
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Informed consent signed.
Exclusion Criteria
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Malformation, tumor, abscess or other major non-ischemic brain disease (e.g., multiple sclerosis) on baseline head CT or MRI.
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Isolated or pure sensory symptoms (e.g., numbness), isolated visual changes, or isolated dizziness/vertigo without evidence of acute infarction on baseline head CT or MRI.
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Iatrogenic causes (angioplasty or surgery) of minor stroke or TIA.
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Preceding moderate or severe dependency (modified Rankin scale [mRS] score 3-5).
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Contraindication to clopidogrel, ticagrelor or aspirin
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Known allergy
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Severe renal (creatinine exceeding 1.5 times of the upper limit of normal range) or hepatic (ALT or AST > twice the upper limit of normal range) insufficiency
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Severe cardiac failure (NYHA level: III to IV)
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History of hemostatic disorder or systemic bleeding
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History of thrombocytopenia or neutropenia
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History of drug-induced hematologic disorder or hepatic dysfunction
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Low white blood cell (<2×109/L) or platelet count (<100×109/L)
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Hematocrit (HCT) <30%
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Clear indication for anticoagulation (presumed cardiac source of embolus, e.g., atrial fibrillation, prosthetic cardiac valves known or suspected endocarditis)
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History of intracranial hemorrhage or amyloid angiopathy
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History of aneurysm (including intracranial aneurysm and peripheral aneurysm)
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History of asthma or COPD (chronic obstructive pulmonary disease)
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High-risk for bradyarrhythmia (first-degree or second-degree AV block caused by sinus node disease, and brady-arrhythmic syncope without pacemaker)
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History of hyperuricemia nephropathy
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Anticipated requirement for long-term (>7 days) non-steroidal anti-inflammatory drugs (NSAIDs)
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Planned or likely revascularization (any angioplasty or vascular surgery) within the next 3 months
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Scheduled for surgery or interventional treatment requiring study drug cessation
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Severe non-cardiovascular comorbidity with life expectancy < 3 months
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Inability to understand and/or follow research procedures due to mental, cognitive, or emotional disorders
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Dual antiplatelet treatment (or more than two antiplatelet agents) in 72 hours before randomization
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Current treatment (last dose given within 10 days before randomization) with heparin therapy or oral anti coagulation
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Intravenous thrombolytic therapy (such as intravenous rtPA) or mechanical thrombectomy within 24 hours prior to randomization
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Gastrointestinal bleed within 3 months or major surgery within 30 days
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Diagnosis or suspicious diagnosis of acute coronary syndrome
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Participation in another clinical study with an experimental product during the last 30 days
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Currently receiving an experimental drug or device
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Pregnant, currently trying to become pregnant, or of child-bearing potential and not using birth control
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Anqing Municipal Hospital | Anqing | Anhui | China | 246003 |
2 | The First Affiliated Hospital of Bengbu Medical College | Bengbu | Anhui | China | 233004 |
3 | Beijing Chaoyang Hospital, Capital MedicalUniversity(west Hospital) | Beijing | Beijing | China | 100043 |
4 | Beijing Tian tan Hospital | Beijing | Beijing | China | 100070 |
5 | Beijing Shunyi Airport Hospital | Beijing | Beijing | China | 101318 |
6 | The First Hospital of Fangshan District | Beijing | Beijing | China | 102488 |
7 | Beijing Coal Group Hospital | Beijing | Beijing | China | |
8 | Peking University Third Hospital | Beijing | Beijing | China | |
9 | Chongqing People's Hospital | Chongqing | Chongqing | China | 400010 |
10 | The Second Affiliated Hospital of Chongqing Medical University | Chongqing | Chongqing | China | 400010 |
11 | Chongqing Sanbo Chang 'an Hospital | Chongqing | Chongqing | China | 400023 |
12 | Daping Hospital of Army Military Medical University | Chongqing | Chongqing | China | 400042 |
13 | The First Affiliated Hospital of Chongqing Medical University | Chongqing | Chongqing | China | 400060 |
14 | Chongqing Fifth People's Hospital | Chongqing | Chongqing | China | 400062 |
15 | The Third Affiliated Hospital of Chongqing Medical University | Chongqing | Chongqing | China | 401120 |
16 | People's Hospital of Rongchang District, Chongqing, | Chongqing | Chongqing | China | 402460 |
17 | Chongqing Three Gorges Central Hospital | Chongqing | Chongqing | China | 404000 |
18 | Chongqing Kaizhou District People's Hospital | Chongqing | Chongqing | China | 405400 |
19 | Chongqing Fuling Central Hospital | Chongqing | Chongqing | China | 408000 |
20 | Chongqing Nanchuan District People's Hospital | Chongqing | Chongqing | China | 408400 |
21 | Xiushan Tujia and Miao Autonomous County People's Hospital | Chongqing | Chongqing | China | 409900 |
22 | The Third Affiliated Hospital of Fujian University of Traditional Chinese Medicine | Fuzhou | Fujian | China | 350025 |
23 | Fuzhou Second Hospital | Fuzhou | Fujian | China | |
24 | Sanming First Hospital Affiliated to Fujian Medical University | Sanming | Fujian | China | 100043 |
25 | Wuwei People's Hospital | Wuwei | Gansu | China | 733000 |
26 | Zhangye People's Hospital Affiliated to Hexi College | Zhangye | Gansu | China | 734000 |
27 | Dongguan People's Hospital | Dongguan | Guangdong | China | 523000 |
28 | The Second Affiliated Hospital of Guangzhou Medical University | Guangzhou | Guangdong | China | 510260 |
29 | Nanfang Hospital Of Southern Medical University | Guangzhou | Guangdong | China | 510515 |
30 | The First Affiliated Hospital of Jinan University | Guangzhou | Guangdong | China | 510632 |
31 | The first Affiliated Hospital of Shantou University Medical College | Shantou | Guangdong | China | 515041 |
32 | Guiyang Second People's Hospital | Guiyang | Guizhou | China | 550000 |
33 | Affiliated Hospital of Guizhou Medical University | Guiyang | Guizhou | China | 550004 |
34 | Hainan West Central Hospital | Danzhou | Hainan | China | 571799 |
35 | The First Affiliated Hospital of Hainan Medical University | Haikou | Hainan | China | 570102 |
36 | Affiliated Hospital of Hebei Medical University | Baoding | Hebei | China | 071000 |
37 | Affiliated Hospital of Hebei University | Baoding | Hebei | China | 071000 |
38 | The Affiliated Hospital of Chengde Medical College | Chengde | Hebei | China | 067000 |
39 | Hejian People's Hospital | Hejian | Hebei | China | 062450 |
40 | HaLixun InternationalPeace Hospital | Hengshui | Hebei | China | 053000 |
41 | Hengshui fourth People Hospital(Department of Neurology ward 2) | Hengshui | Hebei | China | 053000 |
42 | The Fourth People's Hospital of Hengshui City(Department of Neurology ward 1) | Hengshui | Hebei | China | 053000 |
43 | The Second Hospitalof Hebei Medical University | Shijiazhuang | Hebei | China | 050000 |
44 | The First Affiliated Hospital of Hebei North University | Zhangjiakou | Hebei | China | 75000 |
45 | Second Central Hospital of Baoding | Zhuozhou | Hebei | China | 072750 |
46 | Daqing Oilfield Gengeal Hospital | Daqing | Heilongjiang | China | 163001 |
47 | Daqing People's Hospital | Daqing | Heilongjiang | China | 163361 |
48 | The First Hospital of Harbin Medical University | Harbin | Heilongjiang | China | 150001 |
49 | The Second Hospital of Harbin Medical University(Department of Neurology ward 1) | Harbin | Heilongjiang | China | 150086 |
50 | The Second Hospital of Harbin Medical University(Department of Neurology ward ) | Harbin | Heilongjiang | China | 150086 |
51 | The First Affiliated Hospital of Jiamusi University | Jiamusi | Heilongjiang | China | 154002 |
52 | Hongqi Hospital affiliated to Mudanjiang Medical University | Mudanjiang | Heilongjiang | China | 157000 |
53 | Qiqihar Rongjian Institute of Stroke Prevention and Treatment | Qiqihar | Heilongjiang | China | |
54 | Anyang People's Hospital | Anyang | Henan | China | 455000 |
55 | Changge People's Hospital | Changge | Henan | China | 461500 |
56 | Xiuwu County People's Hospital | Jiaozuo | Henan | China | 454350 |
57 | Jiyuan People's Hospital | Jiyuan | Henan | China | 459000 |
58 | Kaifeng Central Hospital | Kaifeng | Henan | China | 475000 |
59 | weishi county Central Hospital | Kaifeng | Henan | China | 475500 |
60 | Luohe Central Hospital | Luohe | Henan | China | 462000 |
61 | Luoyang Central Hospital | Luoyang | Henan | China | 471000 |
62 | The first Affiliated Hospital of Henan University of Science and Technology | Luoyang | Henan | China | 471000 |
63 | The Second Affiliated Hospital of Henan University of Science and Technology | Luoyang | Henan | China | 471000 |
64 | Luoyang New District People's Hospital | Luoyang | Henan | China | 471023 |
65 | Pingdingshan First People's Hospital | Pingdingshan | Henan | China | 467000 |
66 | Sanmenxia Central Hospital | Sanmenxia | Henan | China | 472000 |
67 | Shangqiu Fourth People's Hospital | Shangqiu | Henan | China | 476000 |
68 | Suixian county Hospital of Traditional Chinese Medicine | Shangqiu | Henan | China | 476900 |
69 | Xingyang People's Hospital | Xingyang | Henan | China | 450100 |
70 | The first Affiliated Hospital of Xinxiang Medical University | Xinxiang | Henan | China | 453100 |
71 | The First Affiliated Hospital of Henan University of Traditional Chinese Medicine | Zhengzhou | Henan | China | 450000 |
72 | Gongyi People's Hospital | Zhengzhou | Henan | China | 451200 |
73 | Zhoukou Yongshan Hospital | Zhoukou | Henan | China | 461300 |
74 | Zhumadian Hospital of Traditional Chinese Medicine | Zhumadian | Henan | China | 463000 |
75 | Wuhan No.1 Hospital | Wuhan | Hubei | China | 430000 |
76 | The Central Hospital of Wuhan | Wuhan | Hubei | China | 430014 |
77 | First hospital of Changsha city | Changsha | Hunan | China | 410005 |
78 | Chenzhou First People's Hospital | Chenzhou | Hunan | China | 423000 |
79 | Fourth People's Hospital of Chenzhou | Chenzhou | Hunan | China | 423000 |
80 | The First Affiliated Hospital of Nanhua University | Hengyang | Hunan | China | 421001 |
81 | Loudi City Central Hospital | Loudi | Hunan | China | 417000 |
82 | shaoyang Central Hospital | Shaoyang | Hunan | China | |
83 | Xiangtan Central Hospital | Xiangtan | Hunan | China | 411100 |
84 | Yueyang Second People's Hospital | Yueyang | Hunan | China | 414000 |
85 | The first Affiliated Hospital of Baotou Medical College | Baotou | Inner Mongolia Autonomous Region | China | 014010 |
86 | Baotou CentralHospital | Baotou | Inner Mongolia Autonomous Region | China | 014040 |
87 | The second Affiliated Hospital of Baotou Medical College | Baotou | Inner Mongolia Autonomous Region | China | 14030 |
88 | Wuyuan County People's Hospital | Bayan Nur | Inner Mongolia Autonomous Region | China | 15100 |
89 | Hulun Buir People's Hospital | Buri | Inner Mongolia Autonomous Region | China | 21000 |
90 | Chifeng City Hospital | Chifeng | Inner Mongolia Autonomous Region | China | 024000 |
91 | Affiliated Hospital of Chifeng University | Chifeng | Inner Mongolia Autonomous Region | China | 024005 |
92 | Inner Mongolia People's Hospital | Hohhot | Inner Mongolia Autonomous Region | China | 010017 |
93 | Inner Mongolia International Mongolian Hospital | Hohhot | Inner Mongolia Autonomous Region | China | 010069 |
94 | Shangrao City People's Hospital | Shangrao | Jiang XI | China | |
95 | Huaian Hospital of Traditional Chinese Medicine | Huai'an | Jiangsu | China | 223001 |
96 | Lianshui County People's Hospital | Huai'an | Jiangsu | China | 223400 |
97 | The Second People's Hospital of Lianyungang | Lianyungang | Jiangsu | China | 222023 |
98 | Nanjing Jiangning Hospital | Nanjing | Jiangsu | China | 210000 |
99 | The Second Affiliated Hospital of Nanjing Medical University | Nanjing | Jiangsu | China | 210003 |
100 | Nanjing Gulou Hospital | Nanjing | Jiangsu | China | 210008 |
101 | BenQ Hospital affiliated to Nanjing Medical University | Nanjing | Jiangsu | China | 210019 |
102 | Jiangsu Provincial Hospital of Traditional Chinese Medicine | Nanjing | Jiangsu | China | 210029 |
103 | Nanjing Brain Hospital | Nanjing | Jiangsu | China | 210029 |
104 | The Fourth Affiliated Hospital of Nanjing Medical University | Nanjing | Jiangsu | China | 210031 |
105 | Nanjing Jiangbei People's Hospital | Nanjing | Jiangsu | China | 210048 |
106 | Nanjing Gaochun People's Hospital | Nanjing | Jiangsu | China | 211300 |
107 | Nantong 6th People's Hospital | Nantong | Jiangsu | China | 226000 |
108 | Nantong Hospital of Traditional Chinese Medicine | Nantong | Jiangsu | China | 226000 |
109 | The Third People's Hospital in Tongzhou District, Nantong | Nantong | Jiangsu | China | 226000 |
110 | Affiliated Hospital of Nantong University | Nantong | Jiangsu | China | 226001 |
111 | Nantong First People's Hospital | Nantong | Jiangsu | China | 226001 |
112 | Nantong Second People's Hospital | Nantong | Jiangsu | China | 226002 |
113 | Nantong Fourth People's Hospital | Nantong | Jiangsu | China | 226005 |
114 | Nantong Third People's Hospital | Nantong | Jiangsu | China | 22600 |
115 | Tongzhou District People's Hospital of Nantong City | Nantong | Jiangsu | China | 226300 |
116 | Rudong County People's Hospital | Nantong | Jiangsu | China | 226400 |
117 | Rugao People's Hospital | Nantong | Jiangsu | China | 226500 |
118 | Hai 'an People's Hospital | Nantong | Jiangsu | China | 226600 |
119 | Tongzhou District 8th People's Hospital of Nantong City | Nantong | Jiangsu | China | |
120 | Siyang County People's Hospital | Suqian | Jiangsu | China | 223700 |
121 | Siyang Kangda Hospital | Suqian | Jiangsu | China | 223700 |
122 | Suqian People's Hospital | Suqian | Jiangsu | China | 223800 |
123 | Suzhou Municipal Hospital | Suzhou | Jiangsu | China | 215000 |
124 | The Second Affiliated Hospital of Soochow University | Suzhou | Jiangsu | China | 215004 |
125 | Taizhou People's Hospital | Taizhou | Jiangsu | China | 225300 |
126 | Xinghua People's Hospital | Taizhou | Jiangsu | China | 225700 |
127 | Wuxi People's Hospital | Wuxi | Jiangsu | China | 214000 |
128 | Affiliated Hospital of Jiangnan University | Wuxi | Jiangsu | China | 214041 |
129 | Yixing People's Hospital | Wuxi | Jiangsu | China | 214200 |
130 | Jiangyin People's Hospital | Wuxi | Jiangsu | China | 214400 |
131 | xuzhou Central Hospital | Xuzhou | Jiangsu | China | 221000 |
132 | Xuzhou coal mining group General Hospital | Xuzhou | Jiangsu | China | 221000 |
133 | Affiliated Hospital of Xuzhou Medical University(Department of Neurology ward 1) | Xuzhou | Jiangsu | China | 221002 |
134 | Affiliated Hospital of Xuzhou Medical University(Department of Neurology ward 2) | Xuzhou | Jiangsu | China | 221002 |
135 | Subei People's Hospital of Jiangsu province | Yangzhou | Jiangsu | China | 225009 |
136 | Affiliated Hospital of Yangzhou University | Yangzhou | Jiangsu | China | 225012 |
137 | The fourth peoples hospital of zhenjiang city | Zhenjiang | Jiangsu | China | 212001 |
138 | Ganzhou city people's Hospital | Ganzhou | Jiangxi | China | 341000 |
139 | The First People's Hospital of Jingdehzne City | Jingdezhen | Jiangxi | China | 333000 |
140 | Affiliated Hospital of Jiujiang College | Jiujiang | Jiangxi | China | 332000 |
141 | Jiujiang first people's Hospital | Jiujiang | Jiangxi | China | 332000 |
142 | First Affiliated Hospital of Nanchang University | Nanchang | Jiangxi | China | 330000 |
143 | Jiangxi Provincial People's Hospital | Nanchang | Jiangxi | China | 330006 |
144 | Sino-Japanese Friendship Hospital Of Jilin University | Changchun | Jilin | China | 130031 |
145 | The First Hospital Of Jilin University | Changchun | Jilin | China | 130031 |
146 | Jilin Provincial People's Hospital | Changchun | Jilin | China | |
147 | Xinhua Hospital affiliated to Dalian University | Dalian | Liaoning | China | 116023 |
148 | Second People's Hospital of Huludao City | Huludao | Liaoning | China | |
149 | Shengjing Hospital of China Medical University | Shenyang | Liaoning | China | 110004 |
150 | First People's Hospital of Shenyang | Shenyang | Liaoning | China | 110041 |
151 | Guyuan people's hospital | Guyuan | Ningxia Hui Autonomous Region | China | 756000 |
152 | The Fifth People's Hospital of Ningxia Hui Autonomous Region | Shizuishan | Ningxia Hui Autonomous Region | China | 753000 |
153 | The Second People's Hospital of Shizuishan | Shizuishan | Ningxia Hui Autonomous Region | China | 753000 |
154 | Shizuishan First People's Hospital | Shizuishan | Ningxia Hui Autonomous Region | China | 753200 |
155 | Second people's Hospital of shizuishan | Shizuishan | Ningxia Hui Autonomous Region | China | 753400 |
156 | General Hospital of Ningxia Medical University | Yinchuan | Ningxia Hui Autonomous Region | China | 750001 |
157 | Yinchuan First People's Hospital | Yinchuan | Ningxia Hui Autonomous Region | China | 750001 |
158 | Cardiovascular and Cerebrovoscular Hospital of General Hospital of Ningxia Med. Univ | Yinchuan | Ningxia Hui Autonomous Region | China | 750002 |
159 | People's Hospital of Ningxia Hui Autonomous Region | Yinchuan | Ningxia Hui Autonomous Region | China | 750002 |
160 | Zhongwei People's Hospital | Zhongwei | Ningxia Hui Autonomous Region | China | 755000 |
161 | Baoji High-tech People's Hospital | Baoji | Shaanxi | China | 721000 |
162 | weinan Central Hospital | Weinan | Shaanxi | China | 714000 |
163 | Xi 'an Hi-tech Hospital | Xi'an | Shaanxi | China | 710000 |
164 | Xi 'an Fengcheng Hospital | Xi'an | Shaanxi | China | 710016 |
165 | Xian 141 Hospital | Xi'an | Shaanxi | China | 710089 |
166 | Dezhou People's Hospital | Dezhou | Shandong | China | 2530000 |
167 | Ningjin County People's Hospital | Dezhou | Shandong | China | 253400 |
168 | Shandong Provincial Hospital | Jinan | Shandong | China | 250021 |
169 | Liaocheng City Third People's Hospital | Liaocheng | Shandong | China | 252000 |
170 | Liaocheng People's Hospital | Liaocheng | Shandong | China | 252000 |
171 | Liaocheng Veterans Hospital | Liaocheng | Shandong | China | 252000 |
172 | The Brain Hospital of Liaocheng People's Hospital | Liaocheng | Shandong | China | 252000 |
173 | Guanxian People's Hospital | LiaoCheng | Shandong | China | 252500 |
174 | Liaocheng City Second People's Hospital | Liaocheng | Shandong | China | 252601 |
175 | Dongchangfu people's Hospital | Liaocheng | Shandong | China | |
176 | Liaocheng Central Hospital | Liaocheng | Shandong | China | |
177 | Linqing People's Hospital | Linqing | Shandong | China | 252600 |
178 | Qingdao Municipal Hospital | Qingdao | Shandong | China | 266000 |
179 | Affiliated Hospital of Qingdao University Medical College | Qingdao | Shandong | China | 266071 |
180 | Qingdao West Coast New Area People's Hospital | Qingdao | Shandong | China | 266400 |
181 | Affiliated Hospital of Weifang Medical University | Weifang | Shandong | China | |
182 | Sunshine Union Hospital | Weifang | Shandong | China | |
183 | weihai Central Hospital | Weihai | Shandong | China | 264400 |
184 | Wendeng District People's Hospital | Weihai | Shandong | China | 264400 |
185 | Penglai People's Hospital | Yantai | Shandong | China | 265600 |
186 | Yantai Beihai Hospita | Yantai | Shandong | China | 265701 |
187 | Putuo District Central Hospital | Shanghai | Shanghai | China | 200062 |
188 | Shanghai 7th People's Hospital | Shanghai | Shanghai | China | 200137 |
189 | Changzhi People's Hospital | Changzhi | Shanxi | China | 046000 |
190 | Heping Hospital affiliated to Changzhi Medical College | Changzhi | Shanxi | China | 046000 |
191 | Datong Fifth People's Hospital | Datong | Shanxi | China | 037000 |
192 | The Third People's Hospital of Datong | Datong | Shanxi | China | 037008 |
193 | Shanxi cardiovascular disease hospital | Taiyuan | Shanxi | China | 030024 |
194 | Shanxi Bethune Hospital | Taiyuan | Shanxi | China | 30000 |
195 | Taiyuan Iron and Steel (Group) Co, Ltd,General Hospital | Taiyuan | Shanxi | China | 30001 |
196 | The First Hospital of Shanxi Medical University | Taiyuan | Shanxi | China | |
197 | Xi 'an First Hospital | Xi'an | Shanxi | China | |
198 | Shenzhen Integrated Chinese and Western Medicine Hospital | Shenzhen | Shenzhen | China | 100191 |
199 | Shenzhen Luohu People's Hospital | Shenzhen | Shenzhen | China | 518001 |
200 | Shenzhen Second People's Hospital | Shenzhen | Shenzhen | China | 518035 |
201 | Huazhong University of Science and Technology Union Shenzhen Hospital | Shenzhen | Shenzhen | China | 518052 |
202 | West China Hospital Of Sichuan University | Chengdou | Sichuan | China | 610041 |
203 | Chengdu second Municipal People'sHospital | Chengdu | Sichuan | China | 610000 |
204 | Sichuan Provincial People's Hospital | Chengdu | Sichuan | China | 610072 |
205 | dazhou Central Hospital | Dazhou | Sichuan | China | 635099 |
206 | Tianjin Medical University General Hospital | Tianjin | Tianjin | China | 300052 |
207 | First Affiliated Hospital of Xinjiang Medical University | Guiyang | Xinjiang Autonomous Region | China | 8300054 |
208 | People's Hospital Of Xinjiang Uygur Autonomous Region | Urumqi | Xinjiang Autonomous Region | China | 830001 |
209 | Friendship Hospital of Ili Kazak Autonomous Prefecture | Yining | Xinjiang Autonomous Region | China | 835000 |
210 | First People's Hospital of Yunnan Province | Kunming | Yunnan | China | 650000 |
211 | Hangzhou first people's Hospital | Hangzhou | Zhejiang | China | 310006 |
212 | lishui municipal Central Hospital | Lishui | Zhejiang | China | 323000 |
213 | Zhejiang Wenzhou Medical College Third Affiliated Hospital | Ruian | Zhejiang | China | 325200 |
214 | Taizhou First People's Hospital | Taizhou | Zhejiang | China | 318020 |
Sponsors and Collaborators
- Beijing Tiantan Hospital
- Ministry of Science and Technology of the People´s Republic of China
Investigators
- Principal Investigator: Yongjun Wang, M.D, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2017ZX09304018001
- NCT04952311