Structure of the Herpes Simplex Virus Receptor

Sponsor
National Institute of Allergy and Infectious Diseases (NIAID) (NIH)
Overall Status
Completed
CT.gov ID
NCT00001648
Collaborator
(none)
60
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Study Details

Study Description

Brief Summary

This study will examine the structure of the receptor molecule for the herpes simplex virus (HSV) and determine if the receptor's structure is related to susceptibility to infection with the virus. There are two types of herpes virus-HSV-1 and HSV-2. HSV-1 commonly causes cold sores, and HSV-2 usually causes genital herpes. The herpes virus enters (infects) cells through protein molecules on the cell's surface. This study will explore possible differences between the structure of the HSV receptor molecule in different people to understand better how infection occurs. The study will also look at proteins on white blood cells (Fc receptors, cytokines and mannose binding protein) that may influence the risk of infection with HSV. Information from this study may lead to new treatments to prevent HSV infection.

People 18 years of age and older who are infected with HSV and people who are not infected with the virus may be eligible for this study. Participants will have blood drawn to confirm whether or not they have been infected with the virus. The blood sample will also be used to study the genes for the HSV receptor, Fc receptors, cytokines, mannose binding protein and related proteins on the white blood cells. No more than 40 milliliters (8 teaspoons) of blood will be drawn.

Participants who are found to have antibodies to HSV-2 will be offered counseling and advice on practicing safe sex techniques to help prevent sexually transmitted diseases, including HSV-2 infection.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Herpes simplex virus (HSV) causes genital, orolabial, or cutaneous lesions, keratitis, and encephalitis. Recently cellular receptors for HSV were isolated. The purpose of this study is to identify polymorphisms in the sequence of HSV receptor, cytokines or chemokines and to determine whether these polymorphisms correlate with susceptibility to infection by HSV or with symptoms of HSV. Blood samples from individuals who are seronegative, or seropositive (with or without symptoms of infection) for HSV-2 will be analyzed to determine the sequences of the HSV receptors, cytokines, chemokines, or related proteins. If a new genetic polymorphism is found, additional blood samples from individuals who are seropositive for HSV and from random blood donors will be analyzed to determine the frequency of the polymorphisms in seropositives and in the general population. Knowledge gained from this study should provide important insights into mechanisms of infection by HSV and may lead to novel therapies to block infection.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    60 participants
    Official Title:
    Polymorphism of the Herpes Simplex Virus Receptor
    Study Start Date :
    Aug 20, 1997
    Study Completion Date :
    Apr 13, 2010

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      • INCLUSION CRITERIA:
      HSV-2 Seronegative Patients:

      Individuals known or likely to be seronegative for HSV-2 will be recruited.

      All racial, gender, and ethnic groups will be considered.

      Adult volunteers at least 18 years of age.

      Volunteers who were seronegative for HSV-2 (regardless of HSV-1 serology) confirmed by Western blot.

      Volunteers are willing to allow investigators to store their blood.

      HSV-2 seropositive patients (with or without symptoms):

      All racial and ethnic groups will be considered.

      Volunteers who were seropositive for HSV-2 (regardless of HSV-1 serology) confirmed by Western blot.

      Volunteers are willing to allow investigators to store their blood.

      Normal Controls:

      To determine the frequency of a genetic polymorphism in a population that has not had prior screening for HSV, blood may be obtained from normal control blood donors.

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda Maryland United States 20892

      Sponsors and Collaborators

      • National Institute of Allergy and Infectious Diseases (NIAID)

      Investigators

      None specified.

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00001648
      Other Study ID Numbers:
      • 970166
      • 97-I-0166
      First Posted:
      Nov 4, 1999
      Last Update Posted:
      Jul 2, 2017
      Last Verified:
      Apr 13, 2010
      Keywords provided by , ,
      Additional relevant MeSH terms:

      Study Results

      No Results Posted as of Jul 2, 2017