DESCENDANCE: Subjects With T2D or at Risk of T2D Cohort Follow-up
Study Details
Study Description
Brief Summary
The main objective of this study is to prospectively follow the subjects included in "Descendance" cohort and to describe the occurrence of type 2 diabetes in non-diabetic subjects, which will allow us to iteratively update the "Descendance" Type 2 Diabetes risk prediction model.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Detailed Description
High risk families will be prospectively follow in order to better understand the risk of transmission of type 2 diabetes from one generation to another. The cohort will also allow us to collect additional data on diabetic patients.
The monitoring of the cohort will take place for at least 10 years with a follow-up of all participants every three years. To detect individuals who develop dysglycemia during the study, a glucose tolerance test (GTT) and HbA1c measurement will be conducted.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
T2D group subjects with type 2 diabetes |
Other: Questionnaire
Follow-up questionnaire
|
Non-T2D group healthy subjects |
Diagnostic Test: OGTT
Oral Glucose Tolerance Test
Other: HbA1c
HbA1c measurement
Other: Questionnaire
Follow-up questionnaire
|
Outcome Measures
Primary Outcome Measures
- Type 2 diabetes incidence in Descendance population [9years]
Presence of type 2 diabetes mellitus, on basis of self-reported (physician diagnosis) or diagnosed by OGTT and HbA1c
Secondary Outcome Measures
- Provide estimates of prevalence of diabetes and prediabetes in Descendance population [at baseline, 3-, 6- and 9-years follow-up]
To estimate the prevalence of undiagnosed diabetes mellitus and pre-diabetes in Descendance population
- Study of interactions between risk factors on type 2 diabetes incidence [at baseline, 3-, 6- and 9-years follow-up]
Self-administered questionnaire. "Descendance" specific questionnaire
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Subjects have participated in the Descendance study
-
Subjets who sign informed consent to participate in the study
Exclusion Criteria:
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Subjects not enrolled in Descendance study
-
Subjects refusing to participate
-
Pregnant or breastfeeding
-
Subjects in emergency situations, under legal protection or unable to provide informed -consent
-
Subjects lost to follow-up or died
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète | Évry | France | 91058 |
Sponsors and Collaborators
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
- Institut Pasteur de Lille
Investigators
- Principal Investigator: Guillaume CHARPENTIER, Dr, Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2022-A01538-35