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QUANTHYC: Thyroid Uptake Quantification on a New Generation of Gamma Camera

Sponsor
Centre Hospitalier Princesse Grace (Other)
Overall Status
Completed
CT.gov ID
NCT05049551
Collaborator
(none)
23
Enrollment
1
Location
10.3
Actual Duration (Months)
2.2
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The primary objective of this study is to evaluate the potential of a new large field CZT gamma camera to estimate the thyroid uptake (TU) on Single photon emission computed tomography (SPECT) and SPECT/CT images in comparison with standard planar scintigraphy.

The secondary objective is to analyze the diagnostic contribution of SPECT/CT imaging.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Planar and SPECT/CT scintigraphy will be performed on a new generation large field CZT gamma camera and thyroid uptake (TU) value will be calculated on planar acquisition for 23 consecutive patients referred in our department for hyperthyroidism.

    With a quantitative approach using attenuation, scatter correction and iterative algorithm with resolution recovery we will have the possibility to calculate the TU value with SPECT or SPECT/CT acquisitions.

    Our primary objective will be to evaluate the potential of a new large field CZT gamma camera to estimate the thyroid uptake on SPECT (Tomography without attenuation correction) and SPECT/CT (tomography with attenuation correction) acquisitions compared with standard planar scintigraphy as a gold standard.

    The secondary objective will be to analyze the diagnostic contribution of SPECT/CT images.

    To established this study it will be necessary to introduce cross-calibration factors performed from a thyroid phantom, for planar and SPECT acquisitions, to estimate the thyroid uptake values.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    23 participants
    Observational Model:
    Other
    Time Perspective:
    Retrospective
    Official Title:
    Quantitative Analysis of 99mTc-Pertechnetate Thyroid Uptake With a Large Field CZT Gamma Camera: Feasibility and Comparison Between SPECT/CT and Planar Acquisitions
    Actual Study Start Date :
    Oct 30, 2019
    Actual Primary Completion Date :
    Jun 22, 2020
    Actual Study Completion Date :
    Sep 7, 2020

    Outcome Measures

    Primary Outcome Measures

    1. Thyroid uptake [Inclusion]

      Quantification of thyroid uptake

    Secondary Outcome Measures

    1. SPECT/CT [Inclusion]

      Diagnostic contribution of SPECT/CT

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • Hyperthyroidism confirmed by blood test (TSH) and thyroid ultrasound
    Exclusion Criteria:
    • Pregnant women

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Centre Hospitalier Princesse Grace Monaco Monaco 98000

    Sponsors and Collaborators

    • Centre Hospitalier Princesse Grace

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    Responsible Party:
    Centre Hospitalier Princesse Grace
    ClinicalTrials.gov Identifier:
    NCT05049551
    Other Study ID Numbers:
    • 21-09
    First Posted:
    Sep 20, 2021
    Last Update Posted:
    Sep 20, 2021
    Last Verified:
    Sep 1, 2021
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by Centre Hospitalier Princesse Grace
    thyroid
    uptake
    quantification
    CZT
    Planar
    SPECT/CT
    Additional relevant MeSH terms:
    Hyperthyroidism

    Study Results

    No Results Posted as of Sep 20, 2021