Total Genotype Score, Growth, Maturation and Loading Exposure as Risk Factors for Injury in Elite Male Youth Football

• Sponsor: St Mary's University College (Other)
• Overall Status: Completed
• CT.gov ID: NCT05220969
• Collaborator: Fulham Football Club (Other)
• Enrollment: 95
• Locations: 2
• Actual Duration (Months): 20
• Patients Per Site: 47.5
• Patients Per Site Per Month: 2.4

Study Details

Study Description

Brief Summary

A total genotype risk score was generated based on the findings of previous research for non-contact injury, non-contact muscle injury, tendon injury, ligament injury, fracture injury and apophysitis injury. This score was then compared with the incidence of injury between those with high, medium and low risk scores for each injury. The influence of different rates of growth, stages of physical maturation and loading exposure were then also included in the risk model to see if any interaction effects could be observed between genetic risk score and susceptibility to injury in different categories of growth, maturation and loading exposure.

Condition or Disease	Intervention/Treatment	Phase
Fractures in Children; Apophysitis; Muscle Strain; Ligament Injury; Tendon Injuries; Genetic Predisposition	Genetic: Total Genotype Risk Score

Study Design

• Study Type: Observational
• Actual Enrollment: 95 participants
• Observational Model: Case-Control
• Time Perspective: Retrospective
• Official Title: Total Genotype Score, Growth, Maturation and Loading Exposure as Risk Factors for Injury in Elite Male Youth Football
• Actual Study Start Date: Dec 1, 2019
• Actual Primary Completion Date: Jul 31, 2021
• Actual Study Completion Date: Jul 31, 2021

Arms and Interventions

Arm	Intervention/Treatment
Elite male youth footballers Elite male youth footballers at an English championship / premier league football club	Genetic: Total Genotype Risk Score; A total genotype risk score has been generated based on the results of previously observed genetic association studies

Outcome Measures

Primary Outcome Measures

1. Fracture Injury Risk [8 Years]

   Did the risk of fracture differ between total genotype risk score categories? was this affected by maturation?

2. Non-Contact Injury Risk [8 Years]

   Did the risk of non-contact injury differ between total genotype risk score categories? was this affected by maturation, and loading?

3. Non-Contact Muscle Injury Risk [8 Years]

   Did the risk of non-contact muscle injury differ between total genotype risk score categories? was this affected by maturation, and loading?

4. Tendon Injury Risk [8 Years]

   Did the risk of tendon injury differ between total genotype risk score categories? was this affected by maturation, and loading?

5. Ligament Injury Risk [8 Years]

   Did the risk of ligament injury differ between total genotype risk score categories? was this affected by maturation?

6. Apophysitis Injury Risk [8 Years]

   Did the risk of ligament injury differ between total genotype risk score categories? was this affected by maturation?

Eligibility Criteria

Criteria

• Ages Eligible for Study: 12 Years to 40 Years
• Sexes Eligible for Study: Male
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Elite male football players

Exclusion Criteria:

• Female

• non-elite

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Fulham Football Club	London	New Malden	United Kingdom	KT3 6PT
2	St Mary's University, Twickenham	London	Twickenham	United Kingdom	TW1 4SX

Sponsors and Collaborators

• St Mary's University College
• Fulham Football Club

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: St Mary's University College
• ClinicalTrials.gov Identifier: NCT05220969
• Other Study ID Numbers: SMEC_2019-20_003
• First Posted: Feb 2, 2022
• Last Update Posted: Feb 2, 2022
• Last Verified: Jan 1, 2022

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Disease Susceptibility; Genetic Predisposition to Disease; Wounds and Injuries; Tendon Injuries

Study Results

No Results Posted as of Feb 2, 2022