Online Mindfulness-based Tic Reduction (Phase Two)

Bowdoin College (Other)
Overall Status
Completed ID
Massachusetts General Hospital (Other)

Study Details

Study Description

Brief Summary

Tourette Syndrome (TS) and Persistent Tic Disorder (PTD) are chronic and potentially disabling neurobiological conditions. Although a range of pharmacological and psychosocial treatments exists, a significant number of individuals either do not respond to the current treatments or find them unacceptable. Thus, it is essential that researchers continue to develop and test novel treatment approaches.

In this randomized controlled trial the investigators will compare two different online group-based interventions for tics: a mindfulness-based program (Mindfulness-based Intervention for Tics (MBIT), and a psychoeducational and supportive therapy program (Tic Information and Coping Strategies (TICS)). The purpose of this study is to determine which intervention is more helpful for adults with a tic disorder.

Condition or Disease Intervention/Treatment Phase
  • Behavioral: Mindfulness-based Intervention for Tics
  • Behavioral: Tic Information and Coping Strategies

Study Design

Study Type:
Actual Enrollment :
37 participants
Intervention Model:
Parallel Assignment
Intervention Model Description:
Randomized Controlled TrialRandomized Controlled Trial
Single (Outcomes Assessor)
Primary Purpose:
Official Title:
Online Mindfulness-based Tic Reduction: Development and Testing (Phase Two)
Actual Study Start Date :
Nov 9, 2018
Actual Primary Completion Date :
Dec 2, 2020
Actual Study Completion Date :
Dec 2, 2020

Arms and Interventions

Arm Intervention/Treatment
Experimental: Mindfulness-based Intervention for Tics

8-week group-based mindfulness-based program

Behavioral: Mindfulness-based Intervention for Tics
Psychological intervention that focuses on cultivating awareness of urges to tic and developing a different relationship to those urges through meditation and other mindfulness practices.

Active Comparator: Tic Information and Coping Strategies

8-week group-based educational and supportive therapy program

Behavioral: Tic Information and Coping Strategies
Psychological Intervention that focuses on learning more about tics, practicing a range of strategies for coping with tics (e.g., relaxation, effective communication), and discussing challenges commonly experienced by individuals with tics.

Outcome Measures

Primary Outcome Measures

  1. Change in Yale Global Tic Severity Scale (YGTSS) Total Tic Severity Score [Screening, Week 0, Week 9, Week 13, Week 35]

    Clinician-rated measure of tic severity

Secondary Outcome Measures

  1. Clinical Global Impressions Scale [Weeks 0, 9, 13, 35]

  2. Adult Tic Questionnaire [Weeks 0, 9, 13, 35]

  3. Yale-Brown Obsessive Compulsive Scale [Weeks 0, 9, 13, 35]

  4. Attention-Deficit Hyperactivity Rating Scale [Weeks 0, 9, 13, 35]

  5. Depression Anxiety Stress Scale [Weeks 0, 9, 13, 35]

  6. Premonitory Urge to Tic Scale [Weeks 0, 9, 13, 35]

  7. Tic Rating Form [Weeks 1-8]

  8. Problem Rating Form [Weeks 1-8]

  9. Patient Health Questionnaire-9 [Weeks 0, 9, 13, 35]

  10. Work and Social Adjustment Survey [Weeks 0, 9, 13, 35]

  11. Five Facet Mindfulness Questionnaire [Weeks 0, 4, 8, 9, 13, 35]

  12. Credibility and Expectancy Questionnaire [Week 3]

  13. Patient Satisfaction Questionnaire [Week 9]

  14. Self Compassion Scale [Weeks 0, 9, 13, 35]

  15. Affective Reactivity Index [Weeks 0, 9, 13, 35]

  16. Brief Irritability Test [Weeks 0, 9, 13, 35]

Eligibility Criteria


Ages Eligible for Study:
18 Years and Older
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Inclusion Criteria:
  1. be 18 years of age or older,

  2. possess a primary diagnosis of Tourette Syndrome or Persistent Tic Disorder,

  3. be fluent in English

  4. reside in the United States,

  5. either not be taking any tic suppressant medication or other psychotropic medication or be at a stable dose for 8 weeks prior to the baseline assessment and throughout the study

Exclusion Criteria:
  1. be receiving concurrent psychotherapy for the duration of the study

  2. have prior extensive experience with mindfulness and/or meditation and

  3. have another medical or psychological condition that would prevent the individual from fully engaging in the study or require a higher level of care (e.g., suicidality).

Contacts and Locations


Site City State Country Postal Code
1 Bowdoin College Brunswick Maine United States 04011
2 Massachusetts General Hospital Boston Massachusetts United States 02114

Sponsors and Collaborators

  • Bowdoin College
  • Massachusetts General Hospital


  • Principal Investigator: Hannah Reese, Ph.D., Assistant Professor

Study Documents (Full-Text)

None provided.

More Information


None provided.
Responsible Party:
Hannah Reese, Assistant Professor, Bowdoin College Identifier:
Other Study ID Numbers:
  • 2018-30
First Posted:
Dec 11, 2018
Last Update Posted:
Jan 26, 2021
Last Verified:
Jan 1, 2021
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD:
Studies a U.S. FDA-regulated Drug Product:
Studies a U.S. FDA-regulated Device Product:
Keywords provided by Hannah Reese, Assistant Professor, Bowdoin College
Additional relevant MeSH terms:

Study Results

No Results Posted as of Jan 26, 2021