Transthoracic Ultrasonography Findings and Their Relation to Spirometric Indices in Patients With Obstructive and Restrictive Respiratory Diseases

• Sponsor: Sohag University (Other)
• Overall Status: Recruiting
• CT.gov ID: NCT05175313
• Collaborator: Cairo University (Other)
• Enrollment: 100
• Location: 1
• Anticipated Duration (Months): 5
• Patients Per Site Per Month: 19.9

Study Details

Study Description

Brief Summary

Evaluation of respiratory function is considered a crucial component in the assessment of patients with a wide range of respiratory diseases. Spirometry is considered a common method of measuring pulmonary function. Recently, Transthoracic ultrasound yields important diagnostic information within minutes. Respiratory muscle ultrasound is used to evaluate the anatomy and function of the respiratory system.

Condition or Disease	Intervention/Treatment	Phase
Lung Ultrasound; Spirometry; Respiratory Diseases; Diaphragm Ultrasound	Radiation: transthoracic ultrasonography; Device: spirometry

Study Design

• Study Type: Observational
• Anticipated Enrollment: 100 participants
• Observational Model: Case-Control
• Time Perspective: Prospective
• Official Title: Transthoracic Ultrasonography Findings and Their Relation to Spirometric Indices in Patients With Obstructive and Restrictive Respiratory Diseases
• Actual Study Start Date: Jun 1, 2022
• Anticipated Primary Completion Date: Nov 1, 2022
• Anticipated Study Completion Date: Nov 1, 2022

Arms and Interventions

Arm	Intervention/Treatment
normal people people who don't complain of respiratory diseases will be examined by chest ultrasound and pulmonary function test.	Radiation: transthoracic ultrasonography; lung ultrasonography Diaphragm and respiratory muscle ultrasound inferior vena cava ultrasound; Device: spirometry; pulmonary function test : FVC, FEV1, FEV1/FVC will be measured.
obstructive respiratory diseases the patients who are diagnosed with either COPD or asthma.	Radiation: transthoracic ultrasonography; lung ultrasonography Diaphragm and respiratory muscle ultrasound inferior vena cava ultrasound; Device: spirometry; pulmonary function test : FVC, FEV1, FEV1/FVC will be measured.
restrictive respiratory diseases patient with either ILD	Radiation: transthoracic ultrasonography; lung ultrasonography Diaphragm and respiratory muscle ultrasound inferior vena cava ultrasound; Device: spirometry; pulmonary function test : FVC, FEV1, FEV1/FVC will be measured.

Outcome Measures

Primary Outcome Measures

1. investigate the correlation between transthoracic ultrasonography findings and their relation to spirometric indices in patients with different respiratory diseases. [6months]

   we will study the degree of change in lung ultrasound, diaphragm, and respiratory muscles ultrasound, inferior vena cava ultrasound in obstructive and restrictive respiratory diseases .also, we find their correlation with spirometric indices in these diseases.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

1 -age >18 years 2-patients diagnosed with COPD or asthma. 3-patients diagnosed with ILD or any other restrictive lung diseases. 4-normal people.

Exclusion Criteria:

1. age <18 years old.

2. critically ill patients in intensive care units.

3. patients with neurological diseases.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Sohag university hospital	Sohag		Egypt

Sponsors and Collaborators

• Sohag University
• Cairo University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

• O'Hara DN, Pavlov A, Taub E, Ahmad S. Ultrasonographic modeling of diaphragm function: A novel approach to respiratory assessment. PLoS One. 2020 Mar 12;15(3):e0229972. doi: 10.1371/journal.pone.0229972. eCollection 2020.
• Santana PV, Cardenas LZ, Albuquerque ALP, Carvalho CRR, Caruso P. Diaphragmatic ultrasound: a review of its methodological aspects and clinical uses. J Bras Pneumol. 2020 Nov 20;46(6):e20200064. doi: 10.36416/1806-3756/e20200064. eCollection 2020. Review. English, Portuguese.
• Santana PV, Cardenas LZ, de Albuquerque ALP, de Carvalho CRR, Caruso P. Diaphragmatic ultrasound findings correlate with dyspnea, exercise tolerance, health-related quality of life and lung function in patients with fibrotic interstitial lung disease. BMC Pulm Med. 2019 Oct 21;19(1):183. doi: 10.1186/s12890-019-0936-1.
• Smargiassi A, Inchingolo R, Tagliaboschi L, Di Marco Berardino A, Valente S, Corbo GM. Ultrasonographic assessment of the diaphragm in chronic obstructive pulmonary disease patients: relationships with pulmonary function and the influence of body composition - a pilot study. Respiration. 2014;87(5):364-71. doi: 10.1159/000358564. Epub 2014 Apr 11.
• Zanforlin A, Giannuzzi R, Nardini S, Testa A, Soldati G, Copetti R, Marchetti G, Valente S, Inchingolo R, Smargiassi A. The role of chest ultrasonography in the management of respiratory diseases: document I. Multidiscip Respir Med. 2013 Aug 9;8(1):54. doi: 10.1186/2049-6958-8-54.

• Responsible Party: Esraa Faragallah Abdelaal, assistant lecturer, Sohag University
• ClinicalTrials.gov Identifier: NCT05175313
• Other Study ID Numbers: Soh-Med-21-12-15
• First Posted: Jan 3, 2022
• Last Update Posted: Aug 2, 2022
• Last Verified: Jul 1, 2022

• Individual Participant Data (IPD) Sharing Statement: Undecided
• Plan to Share IPD: Undecided
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Respiration Disorders; Respiratory Tract Diseases

Study Results

No Results Posted as of Aug 2, 2022