A Phase I/II Study of MGCD0103 (MG-0103) in Combination With Gemcitabine

Sponsor

Mirati Therapeutics Inc. (Industry)

Overall Status

Completed

CT.gov ID

NCT00372437

Collaborator

(none)

Enrollment

Locations

Arm

Duration (Months)

5.9

Patients Per Site

0.2

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Inthis study, MGCD0103, a new anticancer drug under investigation, is given three times weekly in combination with gemcitabine to patients with solid tumours.

Condition or Disease	Intervention/Treatment	Phase
Tumors	Drug: MGCD0103 Drug: Gemcitabine	Phase 1/Phase 2

Study Design

Study Type:

Interventional

Actual Enrollment :

47 participants

Allocation:

Non-Randomized

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

A Phase I/II Study of MGCD0103 (MG-0103) in Combination With Gemcitabine

Study Start Date :

Sep 1, 2006

Actual Primary Completion Date :

Dec 1, 2008

Actual Study Completion Date :

Dec 1, 2008

Arms and Interventions

Arm	Intervention/Treatment
Experimental: 1	Drug: MGCD0103 MGCD0103 as an oral dose three times per week. Drug: Gemcitabine Gemcitabine 1000mg/m<2> intravenously days 1, 8, 15 of a 28 day cycle.

Arm

Intervention/Treatment

Experimental: 1

Drug: MGCD0103

MGCD0103 as an oral dose three times per week.

Drug: Gemcitabine

Gemcitabine 1000mg/m<2> intravenously days 1, 8, 15 of a 28 day cycle.

Outcome Measures

Primary Outcome Measures

Maximum tolerated dose in combination with azacitidine [1 year (anticipated)]
Response rate [1 year (anticipated)]

Secondary Outcome Measures

Objective response. [1 year (anticipated)]
Pharmacodynamics (histone acetylation, biomarkers) [1 year (anticipated)]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Patients must have histologically or cytologically documented cancer: Phase I--solid tumors where gemcitabine is considered standard of care; refractory solid tumor with no reasonable likelihood of achieving clinical benefit with existing therapies, that has failed to respond to standard therapy, has progressed despite standard therapy, or for which no standard therapy exists. Phase II--locally advanced and measurable (non-resectable III) or metastatic (Stage IV) pancreatic cancer.
Patients with known CNS metastases may be enrolled on Phase I or II only if they meet the following criteria:
They have received radiotherapy for their CNS disease;
They have had steroids discontinued for at least 1 month prior to study entry;
They have had a CT or MRI of the brain within 1 month of study entry that shows stable disease; and d)they are free of neurological symptoms.
Karnofsky performance status of 70 or greater.
Age 18 years and over.
Laboratory requirements (must be done within 14 days prior to study initiation):
Hematology: White Blood Cells (WBC)≥3 x 10<9>/L (≥ 3000/mm3);
Absolute Neutrophil Count (ANC) ≥1.5 x 10<9>/L (≥1500/mm3);
Platelets ≥100 x 10<9>/L (≥100,000/mm3);
Chemistry: Total Bilirubin ≤1.5 x Upper Limit of Normal(ULN);
AST(SGOT)and ALT(SGPT)≤3 x ULN; ≤ 5 x ULN if documented liver metastases;
Serum Creatinine ≤1.5 x ULN or calculated creatinine clearance ≥50 mL/min;
Urinalysis: Proteinuria <1 mg/dl or 500 mg protein/24 hours if dipstick ≥2+.
Patients or their legal representative must be able to read (or have read to them), understand, and sign a written informed consent (approved by the institutional review board/Ethics Committee (IRB/EC)) within 14 days prior to start of treatment.

Exclusion Criteria:

Patients with another active cancer (excluding basal cell carcinoma or cervical intraepithelial neoplasia (CIN/cervical in situ or melanoma in situ). (Phase II portion only)
Pregnant or lactating women. Women of child bearing potential (WOCBP) must have a negative serum pregnancy test documented within 7 days prior to starting study drug.
WOCBP and men whose partners are WOCBP must use an acceptable method of contraception while enrolled on this study, and for a period of 3 months following study drug treatment. Patients unwilling or unable to follow this guideline will be excluded. Investigators should follow their Institutional standard regarding acceptable methods of contraception.
Patients with uncontrolled concomitant illness, active infection requiring i.v. antibiotics, or uncontrolled infections, or a fever >38.5C on the day of scheduled dosing.
Patients with serious illnesses, medical conditions, or other medical history, including laboratory results, which, in the investigator's opinion, would be likely to interfere with a patient's participation in the study, or with the interpretation of the results.
Patients who have been treated with any investigational drug within 28 days prior to study initiation (an investigational drug is one for which there is no approved indication), or who are receiving concurrent treatment with other experimental drugs or anti-cancer therapy.
Known hypersensitivity to HDAC inhibitors or to any of the components of MG-0103.
Known hypersensitivity to gemcitabine.
Prior treatment with gemcitabine (during the expanded phase II portion only).
Known HIV or known active Hepatitis B or C.
Any condition (e.g., known or suspected poor compliance, psychological instability, geographical location, etc.) that, in the judgment of the investigator, may affect the patient's ability to sign the informed consent and undergo study procedures.
Any condition that will put the patient at undue risk or discomfort as a result of adherence to study procedures. For example, consider requirement to take MG-0103 with a low pH drink and recommendation to avoid agents that increase gastric pH.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Indiana University Cancer Center	Indianapolis	Indiana	United States	46202
2	Veterans Affairs Medical Center	Kansas City	Kansas	United States	64128
3	Duke University Medical Center	Durham	North Carolina	United States	27710
4	Gabrail Cancer Center	Canton	Ohio	United States	44718
5	Pennsylvania Presbyterian Medical Center	Philadelphia	Pennsylvania	United States	19104-4283
6	Vanderbilt University Medical Center	Nashville	Tennessee	United States	37232-6307
7	McGill University/Dept Oncology	Montreal	Quebec	Canada	H2W 1S6
8	CHUS Hopital Fleurimont	Sherbrooke	Quebec	Canada	J1H 5N4